Multiple meningiomas

Waga, Shiro; Matsuda, Masayuki; Handa, Hajime; Matsushima, Masayuki; Ando, Kyozo

doi:10.3171/jns.1972.37.3.0348

Cited by 43 publications

(5 citation statements)

References 15 publications

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“…Excluding neurofibromatosis, multiple meningiomas have been shown to result from dissemination in the cerebrospinal fluid at the time of operation [6,14] or to spread via the blood stream [11], In the absence of neurofibro matosis the presence of multiple meningiomas as in our case is very in frequent and the presence of these tumors in separate neuroaxial compart ments is extremely rare. Location of tumors in the foramen magnum is most unusual [7], Most of the reports are of benign tumors.…”

Section: Discussionmentioning

confidence: 85%

Multiple Meningiomas in Separate Neuroaxial Compartments in a Child

Schiffer¹,

Mundel²,

Lahat³

et al. 1980

Pediatr Neurosurg

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A case of a child with multiple meningiomas in separated neuroaxial compartments is reported. The first tumor was in the frontal region and was removed surgically when first diagnosed 8 years prior to the appearance of the other tumor. The second tumor was located in the foramen magnum region, and reached considerable dimensions before becoming symptomatic and giving signs of brain stem compression as evidenced by progressive spastic tetraparesis and respiratory disturbances, without hydrocephalus. The diagnosis was confirmed by a low CT scan section, the tumor was successfully removed with the aid of the microscope and the patient made a good recovery.

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Section: Discussionmentioning

confidence: 85%

Multiple Meningiomas in Separate Neuroaxial Compartments in a Child

Schiffer¹,

Mundel²,

Lahat³

et al. 1980

Pediatr Neurosurg

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“…Spinal meningioma is known to be the second most common tumour affecting the intradural extramedullary region of the spinal canal, forming approximately 25% of primary spinal cord tumours (13,19). Yet, only a few cases of late recurrence of meningiorna (3,4,12,13,22) and multiple spinal meningiomas have been reported (1,5,14,18,19,21,23) in comparison with the incidence of imracranial meningiorna (2,26,27). Fourteen previous cases are reported in the literatures (Tab.…”

Section: Discussionmentioning

confidence: 99%

“…(3) The tumour in the thoracic region is unusual as it recurred, whether it be metastatic or multiple in origin. The differentiation of multiple meningioma from recurrence cannot readily be de termined (9,10,22,25,27). Metrizamide tOtal myelography by the lumbar route should be performed first, in order to decide the level of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Extradural multiple spinal meningioma

Tsuji¹,

Nishiura²,

Koyama³

1986

Minim Invasive Neurosurg

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A case is reported of recurring or multiple spinal meningioma and focuses again on the incomplete information at present available regarding this class of meningioma. Repeated operations were performed earlier in the extradural space at C2 and an intradural tumour at the same level was completely removed. After a six year interval, we diagnosed an intramedullary meningioma once again at C2, which was subtotally removed. Histological examination indicated an angioblastic tumour, the same type of meningioma as was previously found. Postoperative recovery was satisfactory. Two years later, an intradural extramedullary tumour at T2-3 level was totally removed. Again postoperative recovery went well. In view of the rare occurrence of this meningioma, and the reports on it, we envisaged the pathogenesis of our case as an invasion from the extradural into the intradural space and into the spinal cord. Its appearance in the thoracic region might have been by dissemination via the cerebrospinal fluid pathways or it may have occurred independently.

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“…This hypothesis is supported by histologic and cytogenetic differences observed between different meningiomas in a single patient. 10 , 13 , 15 , 23–28 Conversely, the monoclonal hypothesis proposes that MM originates from a single neoplastic transformed clone that subsequently spreads along the meninges to form multiple monoclonal meningiomas. This hypothesis is supported by the fact that most MM present the same histological features and molecular genetic analyses, including detection of a common NF2 gene mutation that strongly favors a monoclonal origin.…”

mentioning

confidence: 99%

Multiple meningiomas: Epidemiology, management, and outcomes

Fahlström

Dwivedi

Drummond

2023

Neuro-Oncology Advances

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Meningiomas are the most common nonmalignant brain tumor in adults, with an increasing incidence of asymptomatic meningiomas diagnosed on more ubiquitous neuroimaging. A subset of meningioma patients bear 2 or more spatially separated synchronous or metachronous tumors termed “multiple meningiomas” (MM), reported to occur in only 1%–10% of patients, though recent data indicate higher incidence. MM constitute a distinct clinical entity, with unique etiologies including sporadic, familial and radiation-induced, and pose special management challenges. While the pathophysiology of MM is not established, theories include independent origin in disparate locations through unique genetic events, and the “monoclonal hypothesis” of a transformed neoplastic clone with subarachnoid seeding precipitating numerous distinct meningiomas. Patients with solitary meningiomas carry the risk of long-term neurological morbidity and mortality, as well as impaired health-related quality of life, despite being a generally benign and surgically curable tumor. For patients with MM, the situation is even less favorable. MM should be regarded as a chronic disease, and in many cases, the management goal is disease control, as cure is seldom possible. Multiple interventions and lifelong surveillance are sometimes necessary. We aim to review the MM literature and create a comprehensive overview, including an evidence-based management paradigm.

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Multiple meningiomas

Abstract: ✓ Four cases of multiple meningiomas without the stigmata of von Recklinghausen's disease are presented.

Cited by 43 publications

References 15 publications

Multiple Meningiomas in Separate Neuroaxial Compartments in a Child

Multiple Meningiomas in Separate Neuroaxial Compartments in a Child

Extradural multiple spinal meningioma

Multiple meningiomas: Epidemiology, management, and outcomes

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