Multiple keratoacanthomas with peculiar manifestations and course

A Case of Multiple Keratoacanthoma Centrifugum Marginatum

“…From the therapeutic point of view, although spontaneous healing may take place with residual scarring, many patients with multiple keratoacanthomas require adjunctive therapy 16,17 . Among them, the best results have always been reported with methotrexate and retinoids (isotretinoin or etretinate) 18–20 .…”

“…The clinical features in the patient reported did not fit in any of the most common accepted forms of multiple keratoacanthomas (Table 1). Moreover, there are many reported types of keratoacanthomas whose classification is unclear and may overlap, 5,15,16 for example, the association of a giant keratoacanthoma and a keratoacanthoma centrifugum marginatum in a the same patient reported by Schaller et al 5 or the case of a 60‐year‐old Japanese man with unclassified multiple keratoacanthomas reported by Higuchi et al 16 In addition, multiple keratoacanthomas have been described in Muir‐Torre syndrome, xeroderma pigmentosum syndrome, states of deficient cell‐mediated immunity, and those associated with tar therapy 1 . This case showed no evidence of immune deficiency nor exposure to carcinogens, except tobacco.…”

A Case of Multiple Keratoacanthoma Centrifugum Marginatum

“…The clinical features in the patient reported did not fit in any of the most common accepted forms of multiple keratoacanthomas (Table 1). Moreover, there are many reported types of keratoacanthomas whose classification is unclear and may overlap, 5,15,16 for example, the association of a giant keratoacanthoma and a keratoacanthoma centrifugum marginatum in a the same patient reported by Schaller et al 5 or the case of a 60-year-old Japanese man with unclassified multiple keratoacanthomas reported by Higuchi et al 16 In addition, multiple keratoacanthomas have been described in Muir-Torre syndrome, xeroderma pigmentosum syndrome, states of deficient cellmediated immunity, and those associated with tar therapy. 1 This case showed no evidence of immune deficiency nor exposure to carcinogens, except tobacco.…”

“…From the therapeutic point of view, although spontaneous healing may take place with residual scarring, many patients with multiple keratoacanthomas require adjunctive therapy. 16,17 Among them, the best results have always been reported with methotrexate and retinoids (isotretinoin or etretinate). [18][19][20] Some reports suggest that retinoids are mainly effective in the treatment of larger and more typical 19 In our patient, clearance of existing keratoacanthoma and complete suppression of new lesions resulted over a 2-month period of treatment with methotrexate and prednisone.…”

Superficial radiotherapy for multiple keratoacanthomas

“…Multiple KAs are quite rare, except in immunocompromised patients. There are some syndromes characterized by multiple KAs typical of immunocompetent patients; these rare cases may be classified into syndromes without visceral involvement and syndromes with visceral involvement (Table ) .…”