A Case of Multiple Keratoacanthoma Centrifugum Marginatum

Mangas, Cristina; Bielsa, Isabel; Ribera, Miquel; Fernández-Figueras, Ma Teresa; Ferrándiz, Carlos

doi:10.1111/j.1524-4725.2004.30225.x

Cited by 14 publications

(18 citation statements)

References 14 publications

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“…The systemic administration of retinoids has been advocated as both prophylactic and therapeutic treatment for cutaneous neoplastic disorders, especially in the setting of multiple lesions 5,6 . Intralesional methotrexate, bleomycin, and interferon‐α, as well as local and intralesional 5‐fluorouracil, have been reported as therapeutic alternatives 7,8 . In our case, local application of imiquimod cream was given as the patient refused further oral or intralesional treatment.…”

Section: Discussionmentioning

confidence: 81%

Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream

Aroni¹,

Mastoraki²,

Agrogiannis³

et al. 2007

Int J Dermatology

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Section: Discussionmentioning

confidence: 81%

Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream

Aroni¹,

Mastoraki²,

Agrogiannis³

et al. 2007

Int J Dermatology

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“…Our patient had a good and prompt response to acitretin. However, Mangas et al 13 and Das et al 14 reported failure of oral retinoids in their patients. Patients successfully treated with oral retinoids are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 95%

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

Gavrić¹,

Lekić²,

Srećković

et al. 2020

Dermatologic Therapy

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Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of keratoacanthoma, characterized with progressive centrifugal growth, central healing, and atrophy. Due to its rarity and lack of distinctive histopathological features, KCM often raises diagnostic and therapeutic challenge. We present a case of a 76‐year‐old Caucasian woman with a single large tumor on her right shin that responded to oral retinoids. The patient presented history of local trauma. The tumor developed over the course of 20 months from a scar. To the best of our knowledge, this is the fifth case of KCM associated with mechanical trauma as a possible triggering factor.

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“…Failure of retinoid as in our case has been documented earlier. 11 The decision was taken in favor of surgical intervention and wide local excision was planned, considering the fact that the patient showed recurrence following previous inadequate excision. Following our intervention, the patient is showing no recurrence, highlighting that surgical intervention can be adopted as the preferred mode of therapy for KCM, keeping in mind that a wide excision is performed to prevent subsequent recurrence.…”

Section: Discussionmentioning

confidence: 99%

Keratoacanthoma centrifugum marginatum: unresponsive to oral retinoid and successfully treated with wide local excision.

Das

Rathore

et al. 2010

Dermatol Reports

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We describe a case of a 65-year-old male presenting with a large plaque with a rolled-out interrupted margin, atrophic center, and island of normal skin over the left arm. It grew peripherally with central healing, and there was a history of recurrence after inadequate excision. Investigations ruled out other clinical mimickers; namely, squamous cell carcinoma, lupus vulgaris, botryomycosis, and blastomycosis-like pyoderma. Histopathological sections showed irregularly shaped craters filled with keratin and epithelial pearl but no evidence of granuloma or cellular atypia. Clinicopathological correlation proved the lesion to be keratoacanthoma centrifugum marginatum (KCM), a rare variant of keratoacanthoma, which spreads centrifugally, attains a huge size, and never involutes spontaneously. Treatment of KCM has been a problem always and, in our case, systemic retinoid (acitretin for three months) proved ineffective. The patient also had a history of recurrence following surgical intervention previously, necessitating wide excision to achieve complete clearance of tumor cells. Hence, after failure of retinoid therapy, the decision of excision with a 1-centimeter margin was taken and the large defect was closed by a split thickness skin graft. The graft uptake was satisfactory, and the patient is being followed-up presently and shows no signs of recurrence after six months, highlighting wide local excision as a useful treatment option.

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A Case of Multiple Keratoacanthoma Centrifugum Marginatum

Cited by 14 publications

References 14 publications

Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream

Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

Keratoacanthoma centrifugum marginatum: unresponsive to oral retinoid and successfully treated with wide local excision.

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