Multiple imaging radiography at LNLS

Hönnicke, Marcelo Gonçalves; Cusatis, C.; Antunes, Augusto Celso; Safatle, Angélica de Mendonça Vaz; Barros, Paulo Sérgio de Moraes; Morelhão, Sérgio L.

doi:10.1016/j.nima.2007.10.036

Cited by 4 publications

(7 citation statements)

References 37 publications

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“…Experimental images of a 300 µm polyamide wire were acquired with two different ABI non-dispersive setups: Si 333 double crystal setup at 10.7 keV and Si 444 double crystal setup at 18 keV, described elsewhere [18,19]. However, since the detectors are different in both experimental cases, we had to include in our scripts blur due to the image detector instrumentation.…”

Section: Resultsmentioning

confidence: 99%

“…This spoils the image resolution especially if the crystal (or portion of the sample) is set (or it is) at the lower diffraction angle position on its diffraction profile (rocking curve), where the surface component of X-ray extinction can achieve huge values. Note that, very often, in imaging experiments when dynamical diffraction occurs, the extinction depth is considered, theoretically, to have a constant value since the major part of the works take use of the extinction length In this work, the variable extinction depth effect is theoretically and experimentally explored, using as an example, an analyzer-based X-ray phase contrast imaging setup (ABI) [18,19], Fig. 1, with symmetrically-cut perfect single crystals at two different X-ray energies (10.7 keV and 18 keV).…”

Section: Introductionmentioning

confidence: 99%

“…In this work, the variable extinction depth effect is theoretically and experimentally explored, using as an example, an analyzer-based X-ray phase contrast imaging setup (ABI) [18,19], Fig. 1, with symmetrically-cut perfect single crystals at two different X-ray energies (10.7 keV and 18 keV).…”

Section: Introductionmentioning

confidence: 99%

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Intrinsic spatial resolution limit of the analyzer-based X-ray phase contrast imaging technique

Hönnicke

Morelhão

2020

Radiation Physics and Chemistry

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Dynamical diffraction effects always play a role when working with perfect single crystals. The penetration of X-rays respect to the surface normal during diffraction (extinction depth, 1/σe) in perfect single crystals does not have a constant value. The value changes for different angular positions on the crystal diffraction condition. For higher X-ray energies this value can change from few micrometers to tens of millimeters for each different crystal angular position in the small angular range of the diffraction condition. This effect may spread a single point in the object (sample) as a line in the image detector, especially if the crystal is set (or if the sample angularly deviates the beam) at lower diffraction angle positions, where the surface component of X-ray penetration can achieve huge values. Then, for imaging experiments where the dynamical diffraction occurs, such intrinsic property can affect the image resolution. We have modeled and experimentally checked such a dynamical diffraction property using, as example, an Analyzer-based X-ray phase contrast imaging setup (ABI) at two different X-ray energies: 10.7 keV and 18 keV. The results show that our theoretical model is consistent with the measured results. For higher energies the blur effect is enhanced and intrinsically limits the image spatial resolution.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intrinsic spatial resolution limit of the analyzer-based X-ray phase contrast imaging technique

Hönnicke

Morelhão

2020

Radiation Physics and Chemistry

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“…1 ). Other phase contrast X-ray imaging experiments [ 27 , 28 ], including diffraction enhanced imaging [ 29 – 32 ] and PBI [ 9 , 30 ] had been already carried out at LNLS, however, in a diffraction beamline which does not have well prepared optical elements specially for imaging, like IMX has. The IMX beamline is a 20 m long beamline.…”

Section: Methodsmentioning

confidence: 99%

Are Human Peripheral Nerves Sensitive to X-Ray Imaging?

et al. 2015

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Diagnostic imaging techniques play an important role in assessing the exact location, cause, and extent of a nerve lesion, thus allowing clinicians to diagnose and manage more effectively a variety of pathological conditions, such as entrapment syndromes, traumatic injuries, and space-occupying lesions. Ultrasound and nuclear magnetic resonance imaging are becoming useful methods for this purpose, but they still lack spatial resolution. In this regard, recent phase contrast x-ray imaging experiments of peripheral nerve allowed the visualization of each nerve fiber surrounded by its myelin sheath as clearly as optical microscopy. In the present study, we attempted to produce high-resolution x-ray phase contrast images of a human sciatic nerve by using synchrotron radiation propagation-based imaging. The images showed high contrast and high spatial resolution, allowing clear identification of each fascicle structure and surrounding connective tissue. The outstanding result is the detection of such structures by phase contrast x-ray tomography of a thick human sciatic nerve section. This may further enable the identification of diverse pathological patterns, such as Wallerian degeneration, hypertrophic neuropathy, inflammatory infiltration, leprosy neuropathy and amyloid deposits. To the best of our knowledge, this is the first successful phase contrast x-ray imaging experiment of a human peripheral nerve sample. Our long-term goal is to develop peripheral nerve imaging methods that could supersede biopsy procedures.

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“…X-ray wave will deflect from its initial direction by small angles, which depend on the spatial distribution of the mass density [5,7]. Although there is a small density gradient, the DEI technique visualizes the internal structure of a weakly absorbing object with a high spatial resolution [7,[11][12][13]. For this reason, after the relevant fundamental theory was first completed by Chapman et al in 1997 [3][4][5], more and more imaging study with DEI in different aspects such as breast, cartilage and lung tissue, etc., has already been reported [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

X-ray diffraction enhanced imaging study of intraocular tumors in human beings

et al. 2010

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Diffraction enhanced imaging (DEI) with edge enhancement is suitable for the observation of weakly absorbing objects. The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work. The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility (BSRF). The obtained radiographic images were analyzed in correlation with those of pathology. The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time, with good visualization of the microscopic details of eyeball ring such as sclera, choroids and other details of intraocular organelles. And the best resolution of DEI images reaches up to the magnitude of several tens of μm. The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.

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Multiple imaging radiography at LNLS

Cited by 4 publications

References 37 publications

Intrinsic spatial resolution limit of the analyzer-based X-ray phase contrast imaging technique

Intrinsic spatial resolution limit of the analyzer-based X-ray phase contrast imaging technique

Are Human Peripheral Nerves Sensitive to X-Ray Imaging?

X-ray diffraction enhanced imaging study of intraocular tumors in human beings

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