Multiple human papillomavirus infections and type-competition in women from a clinic attendee population in China

Nie, Jianhui; Liu, Jianhua; Xie, Hui; Sun, Zhengrong; Zhao, Juan; Chen, Qingqing; Liu, Yangyang; Huang, Weijin; Ruan, Qiang; Wang, Youchun

doi:10.1002/jmv.24542

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…Some studies demonstrated that multiple infections displayed a longer duration of HPV infection compared to a single infection, which may result in cervical cancer occurrence ( Kim et al, 2021 ). On the contrary, some studies found that single HPV infection had a higher risk of developing into cervical cancer than multiple infections, the possible pathogenic mechanism of which could be competition or a counterbalance between various HPV subtypes ( Nie et al, 2016 ; Li et al, 2019 ). In our study, the prevalence of single HPV infections was higher than that of double and multiple HPV infections.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genotype distribution of HPV infection among women in Xiamen, China

et al. 2023

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ObjectiveThis study aimed to evaluate the prevalence of HPV and genotype distribution among female populations in Xiamen, Fujian Province, China, which can be conducive for local governments to formulate cervical cancer screening and HPV vaccine strategies.MethodsCervical swabs were collected from 47,926 participants aged 16–92 years at the Women and Children’s Hospital, Xiamen University, from November 2019 to June 2020. HPV DNA was extracted and detected using conventional PCR, followed by HPV subtype-specific hybridisation. HPV infection rates based on different groups were compared using the χ2 test. HPV prevalence and the corresponding 95% confidence intervals (95% CI) were calculated using SPSS 19.0.ResultsThe overall HPV prevalence among the 47,926 cervical swabs that were analysed was 15.13%, of which single, double, and multiple infections accounted for 76.83, 16.70 and 6.47%, respectively. The age-specific prevalence of HPV infection presented a “U” curve with a HPV prevalence peak observed in women aged <20 years. The gynaecology clinic group had significantly higher HPV positive rates than the health examination group (p < 0.001). The five most common HR-HPV subtypes in Xiamen were HPV52, 58, 16, 51, and 39 (2.69, 1.63, 1.23, 1.05, and 0.98%, respectively). The five most common LR-HPV subtypes were HPV54, 61, 81, 70, 34, and 84 (0.92, 0.86, 0.71, 0.45 and 0.35%, respectively).ConclusionOur findings demonstrate that the 9-valent HPV vaccine is recommended for regular immunisation in Xiamen. It is necessary for elderly women to participate in HPV screening to decrease the morbidity and mortality of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Prevalence and genotype distribution of HPV infection among women in Xiamen, China

et al. 2023

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“… 23 However, negative interactions were observed between HPV16 and 52, HPV18 and HPV51/52/58, HPV31 and HPV39/51/52/53/54/58, HPV33 and HPV52/58, HPV58 and HPV52, HPV6 and HPV 39/51/52/53/54/56/58, suggesting the possibility of type replacement between these paired types. Negative associations were also observed for HPV16-52 24 and HPV16-51 25 in Chinese and Danish study respectively. While in other studies, multiple positive associations were observed with no statistically significant negative associations.…”

Section: Discussionmentioning

confidence: 76%

Pattern of multiple human papillomavirus infection and type competition: An analysis in healthy Chinese women aged 18–45 years

Su,

Zheng,

et al. 2024

Human Vaccines & Immunotherapeutics

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To assess the pattern of multiple human papillomavirus infection to predict the type replacement postvaccination. A total of 7372 women aged 18–45y from a phase III trial of an Escherichia coli -produced HPV-16/18 vaccine were analyzed at enrollment visit before vaccination. Hierarchical multilevel logistic regression was used to evaluate HPV vaccine type and nonvaccine-type interactions with age as a covariate. Binary logistic regression was construed to compare multiple infections with single infections to explore the impact of multiple-type infections on the risk of cervical disease. Multiple HPV infections were observed in 25.2% of HPV-positive women and multiple infections were higher than expected by chance. Statistically significant negative associations were observed between HPV16 and 52, HPV18 and HPV51/52/58, HPV31 and HPV39/51/52/53/54/58, HPV33 and HPV52/58, HPV58 and HPV52, HPV6 and HPV 39/51/52/53/54/56/58. Multiple HPV infections increased the risk of CIN2+ and HSIL+, with the ORs of 2.27(95%CI: 1.41, 3.64) and 2.26 (95%CI: 1.29, 3.95) for multiple oncogenic HPV infection separately. However, no significant evidence for the type-type interactions on risk of CIN2+ or HSIL+. There is possibility of type replacement between several pairs of vaccine and nonvaccine HPV type. Multiple HPV infection increased the risk of cervical disease, but coinfection HPV types seem to follow independent disease processes. Continued post-vaccination surveillance for HPV 51/52/58 types and HPV 39/51 types separately was essential after the first and second generation of HPV vaccination implementation in China.

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Dynamics of HPV viral loads reflect the treatment effect of photodynamic therapy in genital warts

Liu

Zhang

et al. 2018

Photodiagnosis and Photodynamic Therapy

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Multiple human papillomavirus infections and type-competition in women from a clinic attendee population in China

Cited by 6 publications

References 41 publications

Prevalence and genotype distribution of HPV infection among women in Xiamen, China

Prevalence and genotype distribution of HPV infection among women in Xiamen, China

Pattern of multiple human papillomavirus infection and type competition: An analysis in healthy Chinese women aged 18–45 years

Dynamics of HPV viral loads reflect the treatment effect of photodynamic therapy in genital warts

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