Prevalence and genotype distribution of HPV infection among women in Xiamen, China

Abstract

ObjectiveThis study aimed to evaluate the prevalence of HPV and genotype distribution among female populations in Xiamen, Fujian Province, China, which can be conducive for local governments to formulate cervical cancer screening and HPV vaccine strategies.MethodsCervical swabs were collected from 47,926 participants aged 16–92 years at the Women and Children’s Hospital, Xiamen University, from November 2019 to June 2020. HPV DNA was extracted and detected using conventional PCR, followed by HPV subtype-specific hybridisation. HPV infection rates based on different groups were compared using the χ2 test. HPV prevalence and the corresponding 95% confidence intervals (95% CI) were calculated using SPSS 19.0.ResultsThe overall HPV prevalence among the 47,926 cervical swabs that were analysed was 15.13%, of which single, double, and multiple infections accounted for 76.83, 16.70 and 6.47%, respectively. The age-specific prevalence of HPV infection presented a “U” curve with a HPV prevalence peak observed in women aged <20 years. The gynaecology clinic group had significantly higher HPV positive rates than the health examination group (p < 0.001). The five most common HR-HPV subtypes in Xiamen were HPV52, 58, 16, 51, and 39 (2.69, 1.63, 1.23, 1.05, and 0.98%, respectively). The five most common LR-HPV subtypes were HPV54, 61, 81, 70, 34, and 84 (0.92, 0.86, 0.71, 0.45 and 0.35%, respectively).ConclusionOur findings demonstrate that the 9-valent HPV vaccine is recommended for regular immunisation in Xiamen. It is necessary for elderly women to participate in HPV screening to decrease the morbidity and mortality of cervical cancer.

Characteristics of human papillomavirus prevalence and infection patterns among women aged 25–64 according to age groups and cytology results in Ordos City, China

“…This phenomenon can be attributed to the fact that our study included a hospital-based population, whereby women may have exhibited symptoms of genital diseases and consequently had a higher risk of HPV prevalence compared to healthy women [ 14 ]. While the HPV infection rate may vary geographically across different regions in China [ 15 – 17 ], the HR-HPV prevalence in our study was similar to that reported in other hospital-based studies conducted in China (21.62% vs 21.07%) [ 18 , 19 ].Several factors, such as economic levels, living habits, and knowledge levels, may contribute to the slight variation observed. It is widely accepted that a majority of HPV infections and associated cancers occur in economically disadvantaged areas [ 18 ].…”

Clinical evaluation of primary human papillomavirus (HPV) testing with extended HPV genotyping triage for cervical cancer screening: A pooled analysis of individual patient data from nine population‐based cervical cancer screening studies from China

“… 32 , 33 Previous studies have investigated the HPV genotype distribution among Chinese women but most were based on a single center or healthcare institutions, limiting their ability to provide representation of general population. 9 , 29 , 34 , 35 , 36 , 37 , 38 In this study, we used pooled data from nine population‐based cervical cancer screening studies from six parts of China and identified that the five most frequently detected genotypes were HPV52, 16, 58, 68, and 51. We further evaluated HPV genotype distribution stratified by pathology grade as a proxy for risk assessment to identify genotypes that warrant distinct management.…”

Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

“…Other studies carried out in different geographical areas, mainly in China, have shown similar results. HPV51 has been reported in several studies to be one of the most common circulating genotypes in women, similar to HPV53 and HPV68 [ 52 , 53 , 54 , 55 , 56 ]. As for HPV66, Zheng et al also identified it among the significantly prevalent hrHPV in Chinese women [ 57 ].…”