Multiple Granulocytic Sarcomas in a Patient with Longstanding Complete Remission of Acute Myelogenous Leukemia

Jung, Hee-Dam; Kim, Hei Sung; Park, Young-Min; Kim, Hyung-Ok; Lee, Jun-Young

doi:10.5021/ad.2011.23.s2.s270

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic leukemia cutis (ALC) 267,[287][288][289][290][291][292][293][294][295] or aleukemic myeloid sarcoma. 281,296 Byrd et al 286 proposed using aleukemic to describe those cases of extramedullary involvement in the absence of blood and bone marrow disease for at least 1 month. The literature also includes cases described as aleukemic despite concomitant bone marrow disease in patients who do not have circulating peripheral blasts.…”

Section: Cutaneous Myeloid Neoplasmsmentioning

confidence: 99%

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Gru

Dehner

2018

Pediatr Dev Pathol

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This article focuses on cutaneous hematopoietic neoplasms that are more likely to be encountered in the pediatric age-group and includes both lymphoproliferative and histiocytic disorders. The cutaneous hematologic disorders in children have a different epidemiologic profile to what is seen during adulthood. Although mycosis fungoides is the most frequent form of cutaneous lymphoma in adults, it is very rare in children. Because lymphoblastic leukemias and lymphomas are more frequent in the pediatric setting, cutaneous leukemic infiltrates are relatively common in this age-group. Similarly, histiocytic disorders are more common in children, particularly Langerhans cell histiocytosis and juvenile xanthogranuloma. Notably, the histiocytic disorders have undergone significant modifications on their nomenclature in the basis of the molecular characteristics that are present in them. A summary of the most frequent cutaneous hematopoietic disorders in children will be discussed further in this review.

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Section: Cutaneous Myeloid Neoplasmsmentioning

confidence: 99%

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Gru

Dehner

2018

Pediatr Dev Pathol

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“…Somjee et al reported a 5-year old patient with AML-M2, who had myeloid sarcoma in 7 different anatomical parts of the body at the same time [5] . Jung and colleagues reported a patient with AML who had been in CR for 9 years, developed myeloid sarcoma in the form of multiple intrathecal masses and no systemic signs of AML had been observed for seventeen months of the follow-up [6] .…”

Section: Discussionmentioning

confidence: 99%

Multiple Isolated Extramedullary Relapse and Long-term Survival of One AML Patient

Liu

et al. 2020

Preprint

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Background: Granulocytic sarcomas (GS) are very rare. If it occurs after complete remission of acute myeloblastic leukemia（AML）, it indicates a recurrence of AML and a poor prognosis. In such cases, relapse of leukemia occurs within a mean of 10 months following granulocytic sarcoma.Case presentation: Here we present an unusual case of 78-year-old male who presented with AML-M1 38 years ago. After complete remission from AML-M1 6 years later, he developed unusual multiple isolated extramedullary relapses. And the extramedullary relapse occurred 7 times and involved 8 anatomic sites during 15 years. Despite repeated relapses, treatment and physical damage, the patient managed to survive into 2016.However, we did not detect any signs of leukemia after 1992 and his bone marrow and peripheral blood remained normal Until his death. Immunohistochemical results of our case are all the same, suggesting that they were all derived from the recurrence of the same tumor.Conclusions: Extramedullary relapses may occur in AML patients after complete relieve and without the blood count and BM involvement. Accurate diagnosis of GS is important so the patient could to be treated timely. It is a challenge for the pathologist to make the diagnosis, and without immunohistochemistry (IHC), it may be misdiagnosed as another tumor.

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“…[2][3][4][5] The term LC can sometimes be confusing, as a number of other names are used interchangeably. 1,18 Originally, the term "aleukemic" was used in those circumstances in which no leukemic cells were seen in the blood and the total number of white blood cells was either normal or decreased. However, many now prefer the term myeloid sarcoma when there is a nodular infiltrate of immature blasts in the dermis.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Aleukemic Leukemia Cutis

Gru

Coughlin

Schapiro

et al. 2015

The American Journal of Dermatopathology

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Leukemia cutis (LC) denotes a cutaneous infiltration of neoplastic myeloid cells or lymphoid blasts, which can present in the setting of acute myeloid leukemia, particularly in those cases with monocytic or myelomonocytic differentiation. Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic LC (ALC). Recognition of LC is important for further classification and early diagnosis of the disease, but the diagnosis is difficult in the absence of a systemic presentation of acute leukemia. Although the molecular and cytogenetic features of ALC are poorly characterized, some have shown specific molecular alterations in common with classic forms of acute leukemias. We present 3 cases of ALC in pediatric patients.

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Multiple Granulocytic Sarcomas in a Patient with Longstanding Complete Remission of Acute Myelogenous Leukemia

Cited by 5 publications

References 17 publications

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Multiple Isolated Extramedullary Relapse and Long-term Survival of One AML Patient

Pediatric Aleukemic Leukemia Cutis

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