Multiple gingival metastasis of adenocarcinoma of the lung

Abstract

Metastasis to the gingival soft tissues is an extremely rare phenomenon, and metastasis of multiple lesions (i.e. more than 2 lesions), is even more hard to find. In this study, we have reported a rare case of lung adenocarcinoma, which metastasized to the maxillary (2 lesions) and mandibular gingivae (1 lesion) in a 57 year old male patient. Metastasis was also seen to the vertebrae. The differential diagnosis consisted of acute myelomonocytic leukemia, chronic lymphocytic leukemia, haemangioma, pyogenic granuloma, giant cell granuloma, peripheral fibroma, primary gingival carcinoma and secondary metastasis. Contrast enhanced computed tomography of the lung showed a well-defined mass situated below the right hilum with lower lobe consolidation and pleural effusion on the right side with dorsal spinal metastasis. Excisional biopsy of the lesions was consistent with the diagnosis, and the immunohistochemical analysis was positive for cytokeratin 7, carcinoembryonic antigen (CEA), thyroid transforming factor 1 (TTF1), and negative for vimentin and cytokeratin 20 (CK20).

Primary Squamous Cell Carcinoma of Lung Leading to Metastatic Jaw Tumor

“…Oral metastasis is considered as a late complication and frequently associated with multiple organ metastases. Lung is the most common source for cancers that metastasize to the oral soft tissues and breast is the most common primary site for tumors that metastasize to the jawbones [ 3 ]. Current case is atypical with lung malignancy metastasizing to jaw bone.…”

Non-small cell lung cancer metastasis to the oral cavity: a case report

“…1 Although rare however, oral metastases have diagnostic (a quarter of them reveal an unknown cancer) and prognostic significance (their presence is correlated with limited survival of the patients). 2 …”

Metastasis of pulmonary adenocarcinoma to the oral cavity: A case report and literatures review of the last 30 years

“…Several studies have recommended palliative treatment (e.g., surgical treatment, chemotherapy, and radiotherapy) to improve the quality of life (QOL) and to maintain the patient's comfort 7,8 . We found 54 cases of oral metastasis of PCs that were reported from 1991 to 2021 in PubMed and Google scholar 9–45 and reviewed these cases, including our case. Kaplan‐Meier survival analyses were performed to determine whether palliative treatment affected overall survival.…”