Multiple fungating exophytic nodules secondary to metastatic spiradenocarcinoma with direct spinal cord invasion

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review

“…1,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][85][86][87] Moreover, three other patients with incomplete follow up had poor prognoses in the setting of increasing metastases or discharge to palliative care. 20,31,84 The mortality rate for those with only local disease at the time of diagnosis was 17.2% (15/87 cases). Patients presenting with metastasis were more likely to undergo lymph node dissection and/or adjuvant therapy.…”

“…The mean lesion duration was 168.5 months (range 0-720 months). [12][13][14][15][16][23][24][25][26][27][28][29][30][31][32][33]67,[81][82][83][84][85][86][87] Multiple lesions occurred in 20 cases (14.4%) described by case reports and case series, with histopathology usually confirming a combination of benign and malignant tumours. 4,7 Where reported, presenting symptoms included growth of the lesion (82.6%), pain (47.7%) and ulceration (38.7%).…”

“…1,[19][20][21][24][25][26][27][28][81][82][83][84] Among the 182 cases of spiradenocarcinoma described, 32.3% occurred on the trunk, 31.3% developed on the limbs, 30.7% on the head and neck, and a small number (1.6%) in the genital region. 1,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] Interestingly, six cases were preceded by trauma to the location of the lesion, often several years before the onset of symptoms that prompted the pursuit of medical treatment. 8,15,39,50,66,84 Authors of one of these case reports hypothesized that trauma could be implicated in the pathogenesis of spiradenoma.…”