Multiple Faces of Eyelid Involvement in Sarcoidosis

Sarcoidosis Presenting as Isolated Lower Eyelid Edema

“…The few reported cases on isolated eyelid involvement in sarcoidosis usually respond to oral steroids alone and have systemic association in 42.8% of cases. 1–5 Patients without systemic involvement are usually male similar to our case but tend to be older (mean 47 years of age) compared with our case (27 years).…”

“…The reported incidence of cutaneous involvement in sarcoidosis is 12% to 27% and the incidence of eyelid involvement is even lower. [2][3][4][5] The authors describe a rare presentation of sarcoidosis as unilateral isolated eyelid edema without any systemic involvement that was initially misdiagnosed as preseptal cellulitis.…”

“…Dermatological manifestations are described in literature in approximately 25% (12%-27%) of patients with sarcoidosis. [2][3][4] Cutaneous lesions can present in the form of edema, papules, maculopapular eruptions, plaques, lupus pernio, millet seed nodules, erythrodermic lesions, or rarely destructive skin lesions. [2][3][4] Eyelid lesions have been described in 12% cases of chronic sarcoidosis.…”

“…2–4 Cutaneous lesions can present in the form of edema, papules, maculopapular eruptions, plaques, lupus pernio, millet seed nodules, erythrodermic lesions, or rarely destructive skin lesions. 2–4 Eyelid lesions have been described in 12% cases of chronic sarcoidosis. 1 The eyelid involvement in patients with systemic sarcoidosis can present as an initial cutaneous lesion like simple eyelid swelling with or without hyperemia, plaque like lesions on eyelids, nodules in post blepharoplasty scar, or rarely even destructive eyelid lesions.…”

“…1 The eyelid involvement in patients with systemic sarcoidosis can present as an initial cutaneous lesion like simple eyelid swelling with or without hyperemia, plaque like lesions on eyelids, nodules in post blepharoplasty scar, or rarely even destructive eyelid lesions. 2–5 Apart from the cutaneous involvement in chronic cases of sarcoidosis, there are scattered reports where eyelid lesions are the only and the earliest manifestation of sarcoidosis mostly presenting as eyelid nodules or swelling. 5 Differentiating it from other similar clinicoradiological conditions requires a positive biopsy demonstrating noncaseating granulomas in histopathology.…”