Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)

Effraimidis, Grigoris; Knigge, Ulrich; Rossing, Maria; Oturai, Peter; Rasmussen, Åse Krogh; Feldt‐Rasmussen, Ulla

doi:10.1016/j.semcancer.2021.04.011

Cited by 25 publications

(14 citation statements)

References 344 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A patient with MEN1 syndrome may associate malignant cutaneous tumors, with or without a clear genetic connection, and this scenario should not be overlooked, but we cannot routinely recommend a certain protocol of dermatologic assessment and re-assessment depending on what we know so far. Moreover, integrating the dermatological issues to a general panel of a MEN1 patient evaluation should take into consideration an already complicated panel of surveillance due to traditional endocrine and neuroendocrine components and it should not supplementarily impact the overall quality of life in such individuals [ 25 , 38 , 113 , 114 ].…”

Section: Discussionmentioning

confidence: 99%

Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome–Related Skin Tumors

et al. 2022

View full text Add to dashboard Cite

Non-endocrine findings in patients with MEN1 (multiple endocrine neoplasia) syndrome also include skin lesions, especially tumor-type lesions. This is a narrative review of the English-language medical literature including original studies concerning MEN1 and dermatological issues (apart from dermatologic features of each endocrine tumor/neuroendocrine neoplasia), identified through a PubMed-based search (based on clinical relevance, with no timeline restriction or concern regarding the level of statistical significance). We identified 27 original studies involving clinical presentation of patients with MEN1 and cutaneous tumors; eight other original studies that also included the genetic background; and four additional original studies were included. The largest cohorts were from studies in Italy (N = 145 individuals), Spain (N = 90), the United States (N = 48 and N = 32), and Japan (N = 28). The age of patients varied from 18 to 76 years, with the majority of individuals in their forties. The most common cutaneous tumors are angiofibromas (AF), collagenomas (CG), and lipomas (L). Other lesions are atypical nevi, basocellular carcinoma, squamous cell carcinoma, acrochordons, papillomatosis confluens et reticularis, gingival papules, and cutaneous T-cell lymphoma of the eyelid. Non-tumor aspects are confetti-like hypopigmentation, café-au-lait macules, and gingival papules. MEN1 gene, respective menin involvement has also been found in melanomas, but the association with MEN1 remains debatable. Typically, cutaneous tumors (AF, CG, and L) are benign and are surgically treated only for cosmetic reasons. Some of them are reported as first presentation. Even though skin lesions are not pathognomonic, recognizing them plays an important role in early identification of MEN1 patients. Whether a subgroup of MEN1 subjects is prone to developing these types of cutaneous lesions and how they influence MEN1 evolution is still an open issue.

show abstract

Section: Discussionmentioning

confidence: 99%

Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome–Related Skin Tumors

et al. 2022

View full text Add to dashboard Cite

show abstract

“…MiNENs are a specific type of NENs. NENs are a class of tumours originating from peptidergic neurons and neuroendocrine cells that have neuroendocrine differentiation and express neuroendocrine markers ( 15 ). The histological differentiation of NENs is categorized into two groups: poorly differentiated neuroendocrine carcinomas (NECs) and well-differentiated neuroendocrine tumours (NETs).The neuroendocrine component of the majority of g-MiNENs consists of NECs, and rarely NETs ( 16 ).…”

Section: Definition Of Minensmentioning

confidence: 99%

Gastric mixed neuroendocrine non-neuroendocrine neoplasms

Liu,

Li,

Liu

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

The uncommon tumour known as gastric mixed neuroendocrine-non-neuroendocrine neoplasms (G-MiNENs) is made up of parts of neuroendocrine carcinoma and adenocarcinoma. The biological and clinical features are different from those of gastric adenocarcinoma. Their pathophysiology, diagnostic standards, and clinical behaviour have all been the subject of lengthy debates, and their nomenclature has undergone multiple changes. Its emergence has created new challenges in the classification and diagnosis of gastric tumours. This review will update information on the topic, covering molecular aspects, diagnostic criteria, treatment, and prognostic factor discovery. It will also provide a historical context that will aid in understanding the evolution of the idea and nomenclature of mixed gastric tumours. Additionally, it will provide the reader a thorough understanding of this difficult topic of cancer that is applicable to real-world situations.

show abstract

“…Tese diverse clinical manifestations afect physical functions and cause great damage to the patient's psychological and social functions. Quality of life (QoL) refects the QoL of patients [8][9][10]. Several studies show that PA patients have a low QoL, which difers signifcantly from that of healthy people [11,12].…”

Section: Introductionmentioning

confidence: 99%

Fatigue and Its Contributing Factors in Chinese Patients with Primary Pituitary Adenomas

Zhang

et al. 2023

Journal of Oncology

View full text Add to dashboard Cite

Background. Pituitary adenomas (PAs) refers to a group of benign tumors that develop in the pituitary gland and are often characterized by fatigue. However, fatigue has not been documented in any Chinese research involving people with primary PA. The study sought to examine the prevalence, predictors, and correlation of fatigue with the quality of life (QoL) among PA patients in China. Methods. In total, 203 primary PA patients were included in this cross-sectional study. A series of questionnaires were administered, including the Multidimensional Fatigue Inventory (MFI), M. D. Anderson Symptom Inventory Brain Tumor (MDASI-BT), Short-Form 36 Health Survey (SF-36), Pittsburgh Sleep Quality Index (PSQI), and the Hospital Anxiety and Depression Scale (HADS). Data analysis was accomplished by Pearson or Spearman correlations, linear regression, and simple path analysis. Results. Severe fatigue prior to the initial diagnosis and preparation for surgery affected 50% of PA patients. Depression, sleep disturbance, and MDASI-BT symptom total scores were independently able to predict patient fatigue. Sleep disturbance mediates the influence of depression on fatigue (IE sleep = 0.296, 95% CI: LB = 0.148 to UB = 0.471). Conclusions. Chinese patients with primary PA often report experiencing fatigue. Depression and poor sleep quality were shown to be significant contributors to PA patients’ fatigue. Depression affects PA patients’ fatigue directly or indirectly. Medical professionals should take a proactive approach to PA patients suffering from fatigue before initial diagnosis and preoperative preparation to determine necessary interventions early, thus reducing fatigue and ultimately enhancing their QoL.

show abstract

Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)

Cited by 25 publications

References 344 publications

Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome–Related Skin Tumors

Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome–Related Skin Tumors

Gastric mixed neuroendocrine non-neuroendocrine neoplasms

Fatigue and Its Contributing Factors in Chinese Patients with Primary Pituitary Adenomas

Contact Info

Product

Resources

About