Multiple dynamics of aroylhydrazone induced by mutual effect of solvent and light - spectroscopic and computational study

Benković, Tomislav; Kenđel, Adriana; Parlov-Vuković, Jelena; Kontrec, Darko; Chiş, Vasile; Miljanić, Snežana; Galić, Nives

doi:10.1016/j.molliq.2018.01.158

Cited by 10 publications

(3 citation statements)

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“…All obtained hydrazones were characterized by standard analytical procedures (UV/VIS, NMR, MS, HPLC, X-ray) [34,[37][38][39][40][41][42]. The physico-chemical properties of the compounds 1-12 were investigated and reported [32,36,38,39,41].…”

Section: Chemistrymentioning

confidence: 99%

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Cancer cell growth inhibition by aroylhydrazone derivatives

Илиев

Kontrec

Detcheva

et al. 2019

Biotechnology & Biotechnological Equipment

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Hydrazones have versatile properties that make them promising for a range of possible applications. In this study, we examined a library of 17 aroylhydrazones derived from nicotinic acid hydrazide (1-12) and isonicotinic acid hydrazide (A-E) created by us for their biological activity. The antiproliferative activity of the compounds was investigated on non-tumour MCF-10A cells and cancer cell lines, MCF-7 and MDA-MB-231. Four compounds were selected as most active in cell growth inhibition of the tumour cell lines. These compounds, 5, 11, C and E, were tested on four additional cell lines: non-tumour BJ and cancer cell lines, HeLa, HepG2 and HT-29. Compounds 5 and E exhibited the highest selectivity index on cancer cell lines MDA-MB-231, HeLa and HepG2. High selectivity to MCF-7 cells was demonstrated with compound 5. Compound C was very selective to HepG2 cells as well as to MDA-MB-231 but to a lesser degree. Compound 11 showed selectivity against MDA-MB-231. The obtained results allow assessing the structure-activity relationship of the compounds and provide insight into the further development of this group of aroylhydrazones as more potent and selective anti-neoplastic agents.

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Section: Chemistrymentioning

confidence: 99%

“…In this regard, as part of our study on the analytical application of hydrazones and Schiff bases we prepared and characterized a series of differently substituted aroylhydrazones, both derived from nicotinic acid 1-12 ( Figure 1) [34][35][36][37][38][39][40][41] and isonicotinic acid hydrazide A-E ( Figure 2).…”

Section: Introductionmentioning

confidence: 99%

Cancer cell growth inhibition by aroylhydrazone derivatives

Илиев

Kontrec

Detcheva

et al. 2019

Biotechnology & Biotechnological Equipment

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“…The matrix isolation method can also be effectively used in studies of photo and thermo processes, since the structure of metastable states can remain fixed [ 14 , 15 , 16 , 17 , 18 ]. The application of this method is advantageous for interpreting vibrational spectra thanks to the absence of rotational and phononic modes observed in gas phase and solid state, respectively [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

UV Laser-Induced Phototransformations of Matrix-Isolated 5-Chloro-3-nitro-2-hydroxyacetophenone

Pagacz-Kostrzewa

Mucha

Wierzejewska

et al. 2023

IJMS

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Conformational changes of 5-chloro-3-nitro-2-hydroxyacetophenone were studied by experimental and theoretical methods. Phototransformations of the compound were induced in low-temperature argon matrices by using UV radiation, which was followed by FT-IR measurements. Two types of changes within the molecule were detected: rotations of the hydroxyl and acetyl groups. A new conformer without an intramolecular hydrogen bond was generated upon irradiation with λ = 330 nm, whereas the reverse reaction was observed at 415 nm.

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