Multiple Clustered Dermatofibromas

Abstract

A 37 year-old man developed, over 20 years, multiple clustered dermatofibromas on the left thigh. Three similar cases have been described previously and the benign course of this lesion has been referred to. Analysis of collagen amino acids revealed a sharp increase of hydroxylysine on the fibrous central zone, suggesting an abnormal accumulation of type IV collagen.

Multiple, Clustered Dermatofibroma: A Rare Clinical Variant of Dermatofibroma

“…19 New lesions develop over months to years. This evolutionary behavior may manifest as expansion of the DF plaque 15 or, as in our case and others, 16,18 in the appearance of satellite lesions. Lesions tend to stabilize in FIGURE 1 A well-circumscribed storiform fibrohistiocytic proliferation consistent with a dermatofibroma is present in the papillary and reticular dermis.…”

“…One subject, however developed MCDF in an area of jellyfish contactdermatitis two years following exposure. 16 This history may represent coincidence, or it may lend support to the theoretical pathogenesis of DF as an abortive immunoreactive process mediated by dermal dendritic cells in response to an unknown antigen. 20 Reported cases of MCDF also follow a similar clinical course.…”

“…Six cases of histologically confirmed DF fitting this morphology have been reported, including the current case. [15][16][17][18][19] When considered in aggregate, these cases exhibit substantial similarity in clinical features and behavior, which may warrant recognition of multiple, clustered DF (MCDF) as a distinct clinical variant of DF. MCDF occurs in both sexes, and it appears to have a predilection for the lower extremity, as all reported cases of MCDF developed in the hip/thigh region.…”

Multiple clustered dermatofibroma associated with asymptomatic pericardial cyst

“…This variant of MCDF which is neither congenital nor eruptive is extraordinarily rare, with only 13 cases reported. The clinical characteristics of this case shows all the features common to all cases of this variant form of DF previously reported, these being, occurrence in healthy individual in the second decade, slowly progressive evolution increasing over many years [9,10] and DF typical lesions. The location on the left buttock is also quite typical, and 2 biopsies on different places were consistent with dermatofibroma [11,12] .…”

Multiple Eruptive Dermatofibromas in an HIV-Positive Man

“…Lesions frequently ap peared following the institution of immunosuppressive ther apy with systemic corticosteroids, cyclophosphamide or azathioprine. Multiple DFs have also been described fol lowing a coelenterate sting [4] and without any associated local or systemic disease |3). The underlying etiology of DF is unclear.…”