Multiple cardiac metastases from a malignant melanoma

Chrissos, Dimitrios N.; Stougiannos, Pavlos; Mytas, D.; Katsaros, Andreas; Andrikopoulos, George; Kallikazaros, Ioannis

doi:10.1016/j.euje.2006.12.008

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…Malignant melanoma is the neoplasm most frequently involving the heart [4][5][6][7]. Cardiac metastases of malignant melanomas are diagnosed with increasing frequency, because of the rising incidence and increasing survival of patients with melanoma [8].…”

Section: Image Of the Monthmentioning

confidence: 99%

“…Cardiac metastases of malignant melanomas are diagnosed with increasing frequency, because of the rising incidence and increasing survival of patients with melanoma [8]. Despite massive involvement they are only rarely detected ante mortem (< 30%), because clinical signs and symptoms are often unclear and nonspecific [4]. By contrast, cardiac involvement is found at autopsy in > 50-65% of patients with metastatic malignant melanoma [5,8].…”

Section: Image Of the Monthmentioning

confidence: 99%

“…Malignant melanoma can involve any of the cardiac structures, but most metastases are located in the myocardium, whereas valvular involvement is rare [4][5][6].…”

Section: Image Of the Monthmentioning

confidence: 99%

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Multiple Cardiac Metastases from a Malignant Melanoma Causing Consecutive Pulmonary Embolism

Machnick

Butz

Bracht

et al. 2009

Herz

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A 63-year-old patient, with a history of extirpation of a right atrial myxoma 11 years ago, and a history of malignant skin melanoma surgically removed 7 years ago, was admitted to our department due to fatigue and progressive dyspnea.Transesophageal echocardiography demonstrated multiple metastases in the right atrium and the right ventricle (Figure 1a). A large mobile mass in the right atrium was prolapsing through the tricuspid valve during diastole, mimicking mechanical tricuspid valve stenosis (Figure 1b) [1-3].Magnetic resonance imaging (MRI) demonstrated three intracardial masses with a maximum size of 3.0 × 3.1 cm (Figures 1c and 1d), which had not been detected in a previous MRI performed 5 months earlier. This rapid progression and growth of the metas-

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Section: Image Of the Monthmentioning

confidence: 99%

Section: Image Of the Monthmentioning

confidence: 99%

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Multiple Cardiac Metastases from a Malignant Melanoma Causing Consecutive Pulmonary Embolism

Machnick

Butz

Bracht

et al. 2009

Herz

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“…The American Cancer Society has estimated almost 60 000 new cases of melanoma and over 8000 deaths because of melanoma for 2007. Unlike many types of cancers, which have preferred regions of metastasis, cutaneous melanoma has been observed to metastasize to virtually every tissue, including the gastrointestinal tract, gall bladder, and heart [1][2][3]. Not infrequently, a patient may initially present with a visceral mass that on pathologic evaluation is found to be metastatic melanoma without a known cutaneous primary site.…”

Section: Introductionmentioning

confidence: 96%

Melanoma presenting as circulating tumor cells associated with failed angiogenesis

Lee¹,

Fallarino²,

Ashikari³

et al. 2008

Melanoma Research

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The ability of cancer cells to promote angiogenesis has been associated with a transition from a micrometastatic phenotype to a state in which large solid metastases can form. We describe a case of metastatic melanoma that presented with large numbers of circulating tumor cells and tissue infiltration without large solid metastases. Immunohistochemistry and reverse transcriptase-PCR was used to study the expression of melanoma tumor markers in circulating tumor cells. A tumor cell line was established from the patient and analyzed for adhesion molecule expression, expression of vascular endothelial growth factor, and the ability to inhibit solid tumor formation by other melanoma cells implanted as a xenograft. Examination of the circulating tumor cells confirmed they were of melanoma origin. Analysis of the tumor cell line obtained from this patient demonstrated intact expression of alpha and beta integrins but poor production of vascular endothelial growth factor, and also the ability to inhibit solid tumor formation of third-party melanoma tumors, suggesting a strong antiangiogenic activity. Our results indicate that lethal metastatic melanoma can occur even if tumor angiogenesis is defective, an observation that has implications for potential limits of antiangiogenic therapies.

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“…Por último, el tumor puede asentar en la salida de las arterias coronarias o en los senos valvulares, lo que originaría una obstrucción al flujo, provocando una hipoxia miocárdica [6][7][8] .…”

Section: Introductionunclassified

Muerte súbita por metástasis de melanoma en aurícula derecha: Revisión de los tumores cardiacos

2011

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ResumenLos tumores cardiacos son entidades clínicas muy raras, sin embargo tienen especial interés desde el punto de vista médico-forense porque pueden ser la causa de una muerte súbita. Presentamos el caso de un varón de 38 años de edad con un melanoma de coroides que fallece de forma súbita cuatro años después de realizarse el diagnóstico. La autopsia médico legal y el estudio histopatológico mostraron un tromboembolismo pulmonar originado sobre una metástasis de melanoma en la aurícula derecha. En el presente artículo llevamos a cabo una revisión general de los tumores cardiacos. Palabras clave: Tumores cardiacos. Muerte súbita. Metástasis melanoma. AbstractCardiac tumors are rare clinical entity, however, they have an especial interest in forensic medicine because they can be the source of sudden death. We report a case of a 38-years old male who had been diagnosed with primary choroidal melanoma some years before his sudden death. Forensic autopsy and histopathologic examination revealed pulmonary embolism due to a melanoma metastasis in the right atrium. In addition, in this article we conduct a general review of cardiac tumors.

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Multiple cardiac metastases from a malignant melanoma

Cited by 7 publications

References 4 publications

Multiple Cardiac Metastases from a Malignant Melanoma Causing Consecutive Pulmonary Embolism

Multiple Cardiac Metastases from a Malignant Melanoma Causing Consecutive Pulmonary Embolism

Melanoma presenting as circulating tumor cells associated with failed angiogenesis

Muerte súbita por metástasis de melanoma en aurícula derecha: Revisión de los tumores cardiacos

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