Multiple brain atlas database and atlas-based neuroimaging system

Structural Imaging Reveals Anatomical Alterations in Inferotemporal Cortex in Congenital Prosopagnosia

“…The advent of noninvasive high-resolution structural and fMRI measures has enabled us to begin demarcating the underlying neural substrate in these disorders and has started to shed light on cortical mechanisms subserving brain--behavior relations. In particular, structural measurements of cortical volumes as well as assessment of alterations in tissue density and gray:white matter ratio have proven promising in spite of the tremendous variability in size, shape, and configuration of cortical gyri and sulci across the human brain (Nowinski et al 1997). In this study, we adopted some of these procedures to examine the structural integrity of the cortex in individuals with CP.…”

Optimal location of thalamotomy lesions for tremor associated with Parkinson disease: a probabilistic analysis based on postoperative magnetic resonance imaging and an integrated digital atlas

“…To this end, standardized atlases of subcortical anatomy may be combined with neuroimaging to increase subcortical detail on postoperative images. 2,15,35,58,76,93 The most common application of this technique involves determining the distance between the AC and the PC on postoperative images, and then scaling atlas slices to matching imaging planes. 2,58 Computerized tomography scanningbased atlas integration has been used in this manner to examine thalamotomy characteristics.…”

“…A digitized atlas may be integrated with MR images or CT scans by selecting landmarks or boundaries visible on the image and outlined in the atlas and by using mathematical transformations to scale the atlas to fit the specific image. Scaled digitized atlases matched to a CT or MR image can enhance the planning of stereotactic procedures, 3,58,76,83,93 and linear scaling has the advantage of relatively rapid integration. Nonlinear deformation would allow for a better fit of the atlas, especially in the presence of anatomical variations induced by cortical or subcortical atrophy.…”

AnatomyBrowser: A novel approach to visualization and integration of medical information

“…Work in digital anatomy atlases was pioneered by Höhne et al, 6 followed by other research groups, 7,11 in an effort to develop both extensive medical image databases and visualization software suitable for display and manipulation of medical data. Clinical systems for surgical planning, surgical simulation, and image guided surgery 5,14 are other examples of applications that depend greatly on visualization tools.…”