Optimal location of thalamotomy lesions for tremor associated with Parkinson disease: a probabilistic analysis based on postoperative magnetic resonance imaging and an integrated digital atlas

Atkinson, Jeffrey; Collins, D. Louis; Bertrand, Gilles; Peters, Terry M.; Pike, G. Bruce; Sadikot, Abbas F.

doi:10.3171/jns.2002.96.5.0854

Cited by 64 publications

(49 citation statements)

References 94 publications

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“…The precision of these early lesions is questionable because the postoperative course was complicated by impaired consciousness, "chronic organic brain syndrome," hemiparesis, lateropulsion, impaired gait, and hemiballismus. Contemporary MRI-guided thalamotomy lesions in Parkinson's patients aim for the posterior part of VL and the anterior part of the VP nucleus 120 and do not produce worsening of preexisting cognitive deficits 121 and only mild decline in verbal fluency and in executive functions. 122 …”

Section: Effector Nucleimentioning

confidence: 99%

Vascular Syndromes of the Thalamus

Schmahmann

2003

Stroke

749

589

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Background-This article reviews the anatomy, connections, and functions of the thalamic nuclei, their vascular supply, and the clinical syndromes that result from thalamic infarction. Summary of Review-Thalamic nuclei are composed of 5 major functional classes: reticular and intralaminar nuclei that subserve arousal and nociception; sensory nuclei in all major domains; effector nuclei concerned with motor function and aspects of language; associative nuclei that participate in high-level cognitive functions; and limbic nuclei concerned with mood and motivation. Vascular lesions destroy these nuclei in different combinations and produce sensorimotor and behavioral syndromes depending on which nuclei are involved. Tuberothalamic territory strokes produce impairments of arousal and orientation, learning and memory, personality, and executive function; superimposition of temporally unrelated information; and emotional facial paresis. Paramedian infarcts cause decreased arousal, particularly if the lesion is bilateral, and impaired learning and memory. Autobiographical memory impairment and executive failure result from lesions in either of these vascular territories. Language deficits result from left paramedian lesions and from left tuberothalamic lesions that include the ventrolateral nucleus. Right thalamic lesions in both these vascular territories produce visual-spatial deficits, including hemispatial neglect. Inferolateral territory strokes produce contralateral hemisensory loss, hemiparesis and hemiataxia, and pain syndromes that are more common after right thalamic lesions. Posterior choroidal lesions result in visual field deficits, variable sensory loss, weakness, dystonia, tremors, and occasionally amnesia and language impairment. Conclusions-These vascular syndromes reflect the reciprocal cerebral cortical-thalamic connections that have been interrupted and provide insights into the functional properties of the thalamus.

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Section: Effector Nucleimentioning

confidence: 99%

Vascular Syndromes of the Thalamus

Schmahmann

2003

Stroke

749

589

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“…Neurons in the basal ganglia-recipient thalamus exhibit abnormal activity (oscillating and/or elevated firing rates) during involuntary movements, and thalamotomy/DBS is thought to reduce tremor and rigidity by disrupting this activity [28 ,46 ,47]. Intriguingly, lesions or DBS in the cerebellum-recipient Vim also relieve Parkinsonian tremor [10,45,48], which suggests that the cerebellar and basal ganglia pathways are not independent of each other but interact at some level, for example in the cortex.…”

Section: The Pathway Originating In the Cerebellummentioning

confidence: 99%

The role of the thalamus in motor control

Sommer

2003

Current Opinion in Neurobiology

181

125

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Two characteristics of the thalamus -its apparently simple relay function and its daunting multinuclear structure -have been customarily viewed as good reasons to study something else. Yet, now that many other brain regions have been explored and neurophysiologists are turning to questions of how larger circuits operate, these two characteristics are starting to seem more attractive. First, the relay nature of thalamic neurons means that recording from them, like tapping into a wire, can reveal the signals carried by specific circuits. Second, the concentration of like relay neurons into nuclei means that inactivating or stimulating them can efficiently test the functions of the circuits. Recent studies implementing these principles have revealed pathways through the thalamus that contribute to generating movements and to monitoring one's own actions (corollary discharge).

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“…Using this data, surgeons are able to interpret patient specific image volumes of anatomical, functional, and vascular relevance as well as their relationships. However, atlases can provide histological, functional or cyto-architectonic information to enhance a surgeon's visualization and understanding [1,11]. For example atlases of the basal ganglia and thalamus are required to determine stereotaxic targets for surgical treatment of movement disorders, such as tremor associated with Parkinson's disease [1].…”

Section: Introductionmentioning

confidence: 99%

“…Imaging modalities such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and Computed Tomography (CT) do not allow for a detailed analysis of certain structures in the brain due to their spatial resolution limitations. Digital or computerized atlases can help improve the accuracy and precision of the spatial localization of a region of interest within a patient's brain when used in conjunction with different imaging modalities [1,11].…”

Section: Introductionmentioning

confidence: 99%

“…However, atlases can provide histological, functional or cyto-architectonic information to enhance a surgeon's visualization and understanding [1,11]. For example atlases of the basal ganglia and thalamus are required to determine stereotaxic targets for surgical treatment of movement disorders, such as tremor associated with Parkinson's disease [1]. In the standard stereotaxic method, linear scaling is used to fit an atlas to a patient's anatomy [12].…”

Section: Introductionmentioning

confidence: 99%

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The Creation of a Brain Atlas for Image Guided Neurosurgery Using Serial Histological Data

Chakravarty

Bertrand

Descouteaux

et al. 2003

Lecture Notes in Computer Science

Self Cite

122

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Abstract. Digital atlases of the human brain can help in the specific localization of structures of surgical relevance and interest in Image Guided Neurosurgery (IGNS). This paper outlines one of the steps in the creation of a digital atlas intended for IGNS, using histological data. The acquisition of histological data can include artefacts such as tearing, shearing, stretching, shrinking, as well as inhomogeneous staining leading to structural inhomogeneities. These inconsistencies are reduced using a non-linear intensity based registration procedure where deformations are defined using a maximized correlation coefficient estimate. The intensity artefacts brought about by inhomogeneous staining are reduced by applying a slice to slice intensity inhomogeneity correction by modelling the intensity mapping between slices as a third order polynomial that is estimated with a Least Trimmed Squared fit. The lateral ventricle was then segmented and to demonstrate increased smoothing along its surface.

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Optimal location of thalamotomy lesions for tremor associated with Parkinson disease: a probabilistic analysis based on postoperative magnetic resonance imaging and an integrated digital atlas

Cited by 64 publications

References 94 publications

Vascular Syndromes of the Thalamus

Vascular Syndromes of the Thalamus

The role of the thalamus in motor control

The Creation of a Brain Atlas for Image Guided Neurosurgery Using Serial Histological Data

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