Multiple Bilateral Pulmonary Aspergillomata

Plihal, V; Jedlickova, Z; Viklický, J; Tománek, A

doi:10.1136/thx.19.2.104

Cited by 14 publications

(3 citation statements)

References 5 publications

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“…Patient 2 above may set the record for the largest number of aspergillomas (n = 11), with up to six having been seen previously. 33 The architecture of the lungs of patient 2 was one of gross multiple thin-walled cavitation, notably in the upper lobes. Aspergilloma occurrence in CF was reported in three patients from Dublin, 34 and it is likely that most of these fungal balls arose within bronchi.…”

Section: Resultsmentioning

confidence: 99%

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Multifocal pulmonary aspergillomas: case series and review

Pendleton

Denning

2012

Annals of the New York Academy of Sciences

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Multifocal lung parenchymal cavities containing multiple aspergillomas are not well-recognized features of chronic pulmonary aspergillosis (CPA). We identified five patients with multiple cavities containing fungal balls from our accumulated cohort of ∼300 patients with CPA. Corticosteroid exposure and radiological and serological characteristics were assessed. The patients, aged 19-55 years, developed 3-11 cavities (or nodules in one case) with thin walls, usually within the lung parenchyma, with very limited pleural involvement. Four had asthma (severe in three) and one had cystic fibrosis; three had allergic bronchopulmonary aspergillosis. All patients had received corticosteroids orally or by inhalation. Four patients had elevated Aspergillus IgG antibodies; one had elevated Aspergillus-specific IgE. Three patients developed azole resistance on antifungal therapy, after benefit, one of whom underwent a successful bilateral lung transplant, later complicated by a fatal mycotic cerebral aneurysm. Multiple aspergillomas is a new distinct manifestation of CPA. The lack of inflammatory response and the distribution of the cavities in the lungs are remarkable. Aspergillus nodules could evolve into cavities with aspergillomas. The management and development of azole resistance in these patients is problematic.

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Section: Resultsmentioning

confidence: 99%

“…Patient 2 above may set the record for the largest number of aspergillomas ( n = 11), with up to six having been seen previously 33 . The architecture of the lungs of patient 2 was one of gross multiple thin‐walled cavitation, notably in the upper lobes.…”

Section: Resultsmentioning

confidence: 99%

Multifocal pulmonary aspergillomas: case series and review

Pendleton

Denning

2012

Annals of the New York Academy of Sciences

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“…Mycetomata are usually solitary but can be bilateral (Saliba et al , 1961) or multiple (Plihal et al , 1964; British Tuberculosis Association, 1968). The central mass may liquefy, with formation of a fluid level (Goldberg, 1962).…”

Section: Radiologymentioning

confidence: 99%

Pulmonary Aspergilloma

Joynson

1977

Int J Clinical Practice

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Mycotic infections continue to play an increasingly important role in the practice of medicine and particula rly in pulmonary disease.The histo ry of Aspergillus infection of the lung has been tr aced from the first recognised case to modern conc epts regarding the va rying ways in which the fungu s can manifest itself.The evidence for the possible aetiologies of the tumour-like form of pulmonary aspergillosis-the aspergilloma -has been presented . This has dem o nstrated the saprophytic nature of the infection with under lying pre -existing lung disease in the vast major ity of cases.T he role of corticosteroids. immunosuppressive drug s a nd anti biotic s is con sidered to be of importance

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Aspergillosis

Peña

1971

The Pathologic Anatomy of Mycoses

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Multiple Bilateral Pulmonary Aspergillomata

Cited by 14 publications

References 5 publications

Multifocal pulmonary aspergillomas: case series and review

Multifocal pulmonary aspergillomas: case series and review

Pulmonary Aspergilloma

Aspergillosis

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