Multiple Arterial Thrombosis in a 78-Year-Old Patient: Catastrophic Thrombotic Syndrome in COVID-19

Kénizou, David; Perrin, Clemence; Harzallah, Inès; Bresson, Didier; Allimant, P.; Calcaianu, Mihaela; Lawson, Bree; Morisset, Béatrice; Zuily, Stéphane; Jacquemin, L.; Kinnel, Marine; Girerd, Nicolas

doi:10.1016/j.cjco.2020.09.020

Cited by 9 publications

(5 citation statements)

References 3 publications

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“…They can be fatal due to sudden obstruction of microcirculation, leading to stroke or cardiac death. However, AT is associated in severe COVID-19 cases even in the absence of atherosclerosis or plaque rapture [69] , [70] , [71] ; COVID-19 instigated excessive endothelial activation has been linked to AT in regions such as the aorta, renal, and peripheral arteries [72] . Literature review suggests AT occurs in about 2.2% to 8.8% of seriously affected COVID-19 patients [35] , with thrombosis observed in the superior mesenteric artery (8%), coronary arteries (5% to 9%), great vessels (aorta, common iliac, common carotids, and brachiocephalic artery; 14% to 19%), cerebral arteries (18% to 24%) and limb arteries (24% to 39%) [35] , [73] .…”

Section: Overview Of the Pathophysiology Of Thrombosismentioning

confidence: 99%

COVID-19 and thrombosis: The role of hemodynamics

Sastry

Cuomo

Muthusamy

2022

Thrombosis Research

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Section: Overview Of the Pathophysiology Of Thrombosismentioning

confidence: 99%

COVID-19 and thrombosis: The role of hemodynamics

Sastry

Cuomo

Muthusamy

2022

Thrombosis Research

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“…A total of 55 patients from the database research and 1 patient from our facility were included. 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Of the included studies, 12 were case series and 26 were case reports. Essential characteristics of the included patients are outlined in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

Aortic Thrombosis following COVID-19: A Systematic Review

Petrov¹,

Romera²,

Wilbring³

et al. 2022

Thorac Cardiovasc Surg

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Background Arterial and venous thromboses associated with the coronavirus disease 2019 (COVID-19) have been well described. These events are caused by a hypercoagulable state due to endotheliopathy and infection-driven coagulopathy. There has been an ever-increasing number of documented cases of aortic thrombosis (AoT) in COVID-19 patients. We conducted a systematic review of current scientific literature to identify and consolidate evidence of AoT in COVID-19 patients. Methods A systematic review of literature was conducted between March 15, 2020, and May 1, 2021, on PubMed and Cochrane databases. Additionally, a case from our facility was included. Results A total of 38 studies (12 case series and 26 case reports) and a case from our facility describing AoT in 56 COVID-19 patients were included. Patients were aged 64.8 ± 10.5 years, were predominantly male (75%), and had several comorbidities. AoT was symptomatic in 82,14% of patients; however, when D dimers were reported, they were significantly elevated even in otherwise asymptomatic patients. Most patients had no previous history of aortic disease. Thrombosis was described in all parts of the aorta, with several cases reporting multiple locations. The median reported time until development of AoT was 10 days. Peripheral thrombosis occurred in 73.21% of cases, most commonly causing lower limb ischemia. Mortality rate was 30.4%. Conclusions AoT can occur with no clinical symptoms or as a primary symptom in otherwise asymptomatic COVID-19 patients. D dimers are a highly sensitive diagnostic tool. Diagnosis of this condition prior to development of complications could be instrumental in saving many lives.

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“…Both unilateral and bilateral thromboses have been reported. Moreover, clinical practice has shown that renal artery thrombosis may also occur concomitantly with other thrombotic complications in the body, such as pulmonary embolism and thrombosis in different body zones, such as the heart, aorta, limbs, and brain [21 , 25 , 26] . The majority of the aforementioned cases were strongly correlated with COVID-19-induced thrombosis because the diagnosis was demonstrated by reverse-transcriptase polymerase chain reaction test results, chest imaging findings (eg, ground-glass opacities), and a relatively high D-dimer level.…”

Section: Discussionmentioning

confidence: 99%