Aortic Thrombosis following COVID-19: A Systematic Review

Petrov, Asen; Romera, Juan Pablo De Glee; Wilbring, Manuel; Alexiou, Konstantin; Kappert, Utz; Matschke, Klaus; Tugtekin, Sems Malte

doi:10.1055/s-0041-1740554

Cited by 6 publications

(3 citation statements)

References 52 publications

(59 reference statements)

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“…Although thrombus formation within the right atrium, right ventricle can lead to consecutive pulmonary embolism, this issue is under-reported in the scientific literature and clinical guidelines [ 22 , 23 , 24 , 25 ]. There are also few data on aortic thrombosis in COVID-19 and its combination with venous thrombosis [ 24 , 26 , 27 , 28 , 29 , 30 ]. The results of our study demonstrated that in situ pulmonary artery thrombosis is the most common thrombotic complication identified postmortem.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Thrombotic Complications in Fatal Cases of COVID-19: Focus on Pulmonary Artery Thrombosis In Situ

Babkina

Yadgarov

Волков

et al. 2023

Viruses

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COVID-19-related thrombosis affects the venous and arterial systems. Data from 156 autopsies of COVID-19 patients were retrospectively analyzed to investigate the pattern of thrombotic complications and factors associated with pulmonary artery thrombosis and thromboembolism. Thrombotic complications were observed in a significant proportion (n = 68, 44%), with pulmonary artery thrombosis the most frequently identified thrombotic event (42, 27%). Multivariate analysis revealed that the length of hospital stay (OR 1.1, p = 0.004), neutrophil infiltration in the alveolar spaces (OR 3.6, p = 0.002), and the absence of hyaline membranes (OR 0.1, p = 0.01) were associated with thrombotic complications. Neutrophil infiltration in the alveolar spaces (OR 8, p < 0.001) and the absence of hyaline membranes (OR 0.1, p = 0.003) were also independent predictors of pulmonary artery thrombosis. The association of pulmonary artery thrombosis with an absence of hyaline membranes suggests it occurs later in the course of COVID-19 infection. As neutrophil infiltration in the alveolar spaces may indicate bacterial infection, our studies suggest the consideration of bacterial infections in these critically ill patients.

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Section: Discussionmentioning

confidence: 99%

Spectrum of Thrombotic Complications in Fatal Cases of COVID-19: Focus on Pulmonary Artery Thrombosis In Situ

Babkina

Yadgarov

Волков

et al. 2023

Viruses

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“…Arterial and venous thromboses associated with COVID-19 have been reported in the literature [2][3][4][5]. An association has been detected with a state of hypercoagulability, and the risk of developing venous and arterial thromboembolic events is as high as 31% [6].…”

Section: Introductionmentioning

confidence: 99%

Aortic Thrombosis Associated with Three Types of COVID-19 Vaccine

de Godoy,

Neto,

da Silva

et al. 2023

Case Reports in Surgery

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Aortic thrombosis has been studied little in patients with COVID-19 and an association has recently been reported with the vaccine for this disease. The aim of the present study is to report five cases of aortic thrombosis at our institution within a three-month period associated with the COVID-19 vaccine. Five cases of aortic thrombosis were evaluated—three women and two men aged 29, 49, 51, 60, and 79 years. Four thrombi involved the thoracic aortic and one involved the abdominal aorta, with embolisms found in the kidneys, spleen, liver, upper limbs, and lower limbs. Embolectomy was performed on the limbs, and anticoagulant therapy was performed for the abdominal arteries. The patients recovered well and anticoagulant therapy was maintained. Aortic thrombosis is uncommon but was associated with the AstraZeneca vaccine in this case series.

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“…Since the start of the COVID-19 pandemic, COVID-19 infections have repeatedly been reported to be associated with thrombotic events [1]. These events include appositional thrombi localized in the thoraco-abdominal aorta and iliac arteries, at times even leading to complete occlusion of these vessels [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A Novel Percutaneous Technique for Aorto-Iliac Thrombectomy without the Risk of Embolization

et al. 2023

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Classic surgical thrombectomy of the aorta and iliac arteries through an incision in the groin vessels harbors the risk of embolization to the viscero-renal as well as hypogastric arteries, while percutaneous endovascular thrombectomy techniques can lead to peripheral embolization to the lower limbs. Therefore, we describe a novel, percutaneous technique that tackles the above issues. Furthermore, we also present our initial experience using the technique. The principle of the technique is to percutaneously place large-bore sheaths in the iliac arteries that deliberately occlude the latter to protect the lower limbs from embolization. Through one of these sheaths, over wire Fogarty® catheters can be placed and inflated in the ostia of the coeliac trunk, superior mesenteric artery, renal arteries, and hypogastric arteries as needed. A large thrombectomy balloon catheter is then used to bring any aorto-iliac thrombus into the sheaths, whereafter the thrombus is removed from the sheaths by simply deflating their valves. Additional endovascular procedures of the aorto-iliac branches can be performed as needed. We report nine procedures in 8 patients (4 males and 4 females) with a median age of 63 (53–68.5). Additional endovascular procedures were performed in 6 (66.7%) procedures. All but one procedure were technically successful, and all patients had palpable foot pulses on completion of the procedures, while no patient had clinical signs of peripheral embolization. This technique is a very valid addition to the vascular surgeon’s armamentarium when treating aorto-iliac thrombotic events because it is minimally invasive while still protecting against embolization and offering the flexibility to perform a wide range of additional endovascular procedures where needed.

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Aortic Thrombosis following COVID-19: A Systematic Review

Cited by 6 publications

References 52 publications

Spectrum of Thrombotic Complications in Fatal Cases of COVID-19: Focus on Pulmonary Artery Thrombosis In Situ

Spectrum of Thrombotic Complications in Fatal Cases of COVID-19: Focus on Pulmonary Artery Thrombosis In Situ

Aortic Thrombosis Associated with Three Types of COVID-19 Vaccine

A Novel Percutaneous Technique for Aorto-Iliac Thrombectomy without the Risk of Embolization

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