Multiplatform profiling of rare pancreatic carcinoma subtypes to identify potential actionable targets.

Borazanci, Erkut; Millis, Sherri Z.; Winkler, Josiah; Ramanathan, Ramesh K.; Hoff, Daniel D. Von

doi:10.1200/jco.2014.32.15_suppl.e15229

Cited by 2 publications

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“…p16 and Dpc4 expression are usually lost or reduced and nuclear p53[ 12 ], CA 19.9 and CEA are usually positive[ 12 ] similar to PDA. One study[ 13 ] used an IHC commercial assay[ 14 ] of molecular markers which are implicated in anti-tumor drug performance, showing TOPO2A, MRP1, BCRP and MGMT overexpression. There is not a definitive sign of ASPC in imaging tests, but some studies remark that it is frequently round or has a lobulated shape[ 15 ] with ill-defined borders[ 16 ], and characteristically demonstrates central necrotic areas[ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

Juan

Escribano

Lapiedra

et al. 2017

WJGO

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A 69-year-old woman from a kindred with familial atypical multiple mole melanoma and carrier of a germline mutation in CDKN2A, presented with abdominal pain caused by a solid-cystic pancreatic mass. The patient had an abdominal computed tomography three years before in which there was no evidence of pancreatic lesion. The endoscopic ultrasound guided fine needle aspiration showed adenocarcinoma with squamous component. After surgical resection the final diagnosis was adenosquamous pancreatic carcinoma (ASPC) arising in an intraductal papillar mucinous neoplasm (IPMN). Adenosquamous carcinomas are uncommon in the pancreas and have rarely been described in association with IPMNs. It has worse prognosis than the ordinary pancreatic ductal adenocarcinoma and some distinct features. We review the clinical, imaging, pathologic and molecular aspects of ASPC. Differential diagnosis with contamination, squamous metaplasia and pancreatic metastases from a distant squamous carcinoma is discussed. Besides, the case is an accelerated model of the adenoma (IPMN)-carcinoma sequence probably due to the CDKN2A germline mutation. Somatic CDKN2A mutations are common events in the early steps of sporadic pancreatic cancer, but germline mutation carriers have a significantly higher risk of pancreatic carcinoma.

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Section: Discussionmentioning

confidence: 99%

Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

Juan

Escribano

Lapiedra

et al. 2017

WJGO

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“…Similar to PDA, Carcinoembryonic antigen (CEA) and CA 19.9 are frequently positive [ 6 ]. Molecular markers correlated with antitumor drug performance such as BCRP , MRP1 , TOPO2A , and MGMT , are overexpressed [ 2 , 7 ]. In the literature there are a few cases in which ASCP existed concurrently or in association with intraductal papillary mucinous neoplasm [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Adenosquamous carcinoma of the pancreas: two case reports and review of the literature

et al. 2022

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Background Among the total reported cases of pancreatic duct adenocarcinomas, around 1–2.9% are adenosquamous carcinomas of the pancreas. Due to limited data, preoperative diagnosis is a great challenge for physicians, and it is usually set post-operational, based on the pathologist report. We operated on two cases of adenosquamous carcinoma of the pancreas, which we present alongside the operation and treatment planning. Case report A 69-year-old Caucasian female and a 63-year-old Caucasian male presented themselves with jaundice in our department. The abdomen computed tomography and magnetic resonance imaging scans revealed lesions of the pancreas. A pancreas–duodenumectomy was performed in both patients, and the post-operational histology analysis revealed adenosquamous carcinoma of the pancreas head. The patients were discharged in good condition and received further chemotherapy treatment after surgery. Conclusions Two case reports of adenosquamous carcinoma of the pancreas are described here, which both underwent surgery resection. The limited available literature on this topic substantially limits the knowledge and guidance on treatment. A summarization of the available literature is attempted, alongside a description of possible fields of future research.

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Multiplatform profiling of rare pancreatic carcinoma subtypes to identify potential actionable targets.

Cited by 2 publications

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Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

Adenosquamous carcinoma of the pancreas: two case reports and review of the literature

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