Multiphase hydrogenation of resorcinol in structured and heat exchange reactor systems

Efficient and Continuous Decomposition of Hydrogen Peroxide Using a Silica Capillary Coated with a Thin Palladium or Platinum Layer

“…15 Micro channels with a coating of metal catalyst on their walls can provide remarkable advantages both as heterogeneous catalysis and continuous reaction systems, including, excellent mass and heat transfer properties, large surface area to volume ratio and no need for extra processing required to separate metal catalyst from products. 1618 The major methods used for introducing heterogeneous metal catalyst into capillaries are as slurry 19,20 by solgel deposition 21 or impregnation over the interior surface. 22 Self-assembling of nanoparticles 23 and fabrication by colloidal palladium 24 have also been applied to cover the inner walls of tubular reactors.…”

Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

“…[63] Eine dazwischenliegende Methode ist die Anwendung kontinuierlicher Gas/flüssig/fest-Suspensionsreaktoren. [64] Bei diesem Verfahren ist keine Abnahme der Katalysatoraktivität mit der Zeit zu erwarten, trotzdem kann der Katalysator durch eine nachfolgende Filtration immer noch leicht vom Reaktionsgemisch abgetrennt werden. Wichtig ist, dass die mit Mikroreaktoren verbundenen Vorteile,w ie ein verbesserter Stoff-und Wärmeübergang,erhalten bleiben.…”

Intensification of the solvent-free catalytic hydroformylation of cyclododecatriene: Comparison of a stirred batch reactor and a heat-exchange reactor

“…The process fluid is depressurised at the reactor exit and degassed in the receiver vessel. This set up has been described in detail previously [20,23].…”

“…2). This reactor was chosen because in a previous study, it provided the highest reaction rate for Resorcinol hydrogenation [23] and is composed of 2 mm  2 mm square section channels without splitter bars with the injection of the gas phase performed via a perforated separating plate along the length of the channels. A complex matrix of interconnected channels for heat transfer medium is embedded within the sold metal body, and it is the design of this that allows for high heat transfer rates.…”

“…There appears however to be little or no literature on the use of mm-scale heat-exchange reactors for multiphase reaction. Exceptions to this are the work of Plucinski and co-workers [17][18][19] who have used a packed bed of 150 mm catalyst in 2-5 mm channels in a heat-exchange reactor, and Enache and co-workers who use a 1-3 mm channels with the catalyst in suspended form, and thus as a downflow structured slurry bubble column, initially in single and multiple capillary reactors [20,21] and subsequently in a uncatalysed honeycomb monolith to provide the flow structuration [20,22] and a heat-exchange reactor of with 1-2 mm channel dimensions [23]. Both of these design approaches appear to give productivity gains.…”