Multiparametric Ultrasound Evaluation of the Thyroid: Elastography as a Key Tool in the Risk Prediction of Undetermined Nodules (Bethesda III and IV)—Histopathological Correlation

Moraes, Pedro H.M.; Takahashi, Marcelo Straus; Vanderlei, Felipe Augusto Brasileiro; Schelini, Marcelo V.; Chacon, Danielle Azevedo; Tavares, Marcos Roberto; Chammas, Maria Cristina

doi:10.1016/j.ultrasmedbio.2021.01.019

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…In addition, they concluded that the combination of elastography and other ultrasound techniques improves evaluation of indeterminate thyroid nodules 95 . Moraes et al found similar results 96 . Nell et al showed that for asteria class 1, which is a scale of 1–4 to color code the elastography image, a fraction of up to 15% can be classified as benign without the further need of biopsies or thyroid lobectomy 33 .…”

Section: Diagnosismentioning

confidence: 93%

“…98 However, some drawbacks can be noted: the chosen positions of the transducer with respect to the areas of interest, artifact creation due to calcifications, the pressure exerted by the neck muscles, the breathing and transducer prepressure all may have an effect on the overall stiffness of the nodule and thus confounding factors when not taken into account during acquisition. 96 Hyperextension of the neck may be a solution to the neck muscles and breathing drawbacks. 96 Most of the aforementioned studies did not combine their results with that of an RSS, though this may result in more accurate differentiation.…”

Section: Et Almentioning

confidence: 99%

“…96 Hyperextension of the neck may be a solution to the neck muscles and breathing drawbacks. 96 Most of the aforementioned studies did not combine their results with that of an RSS, though this may result in more accurate differentiation. Pang et al used a logistic regression model to aid in thyroid nodule differentiation, one of the significant factors contributing to the differentiation was the elastography score.…”

Section: Et Almentioning

confidence: 99%

See 2 more Smart Citations

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Boers

Braak

Rikken

et al. 2023

J of Clinical Ultrasound

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Ultrasound, the primary imaging modality in thyroid nodule management, suffers from drawbacks including: high inter-and intra-observer variability, limited field-of-view and limited functional imaging. Developments in ultrasound technologies are taking place to overcome these limitations, including three-dimensional-Doppler, -elastography, -nodule characteristics-extraction, and novel machine-learning algorithms. For thyroid ablative treatments and biopsies, perioperative use of three-dimensional ultrasound opens a new field of research. This review provides an overview of the current and future applications of ultrasound, and discusses the potential of new developments and trends that may improve the diagnosis, therapy, and follow-up of thyroid nodules.

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Section: Diagnosismentioning

confidence: 93%

Section: Et Almentioning

confidence: 99%

Section: Et Almentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Boers

Braak

Rikken

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

“…Most of the published data belong to pilot studies. Most studies have documented promising results in terms of high accuracy for malignancy in thyroid nodules [ 52 ] and cervical lymph nodes [ 53 ]. However, other studies have documented opposite results [ 54 ].…”

Section: Qualitative Diagnosismentioning

confidence: 99%

Qualitative and Quantitative Diagnosis in Head and Neck Cancer

et al. 2021

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The diagnosis is the art of determining the nature of a disease, and an accurate diagnosis is the true cornerstone on which rational treatment should be built. Within the workflow in the management of head and neck tumours, there are different types of diagnosis. The purpose of this work is to point out the differences and the aims of the different types of diagnoses and to highlight their importance in the management of patients with head and neck tumours. Qualitative diagnosis is performed by a pathologist and is essential in determining the management and can provide guidance on prognosis. The evolution of immunohistochemistry and molecular biology techniques has made it possible to obtain more precise diagnoses and to identify prognostic markers and precision factors. Quantitative diagnosis is made by the radiologist and consists of identifying a mass lesion and the estimation of the tumour volume and extent using imaging techniques, such as CT, MRI, and PET. The distinction between the two types of diagnosis is clear, as the methodology is different. The accurate establishment of both diagnoses plays an essential role in treatment planning. Getting the right diagnosis is a key aspect of health care, and it provides an explanation of a patient’s health problem and informs subsequent decision. Deep learning and radiomics approaches hold promise for improving diagnosis.

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“…Shear-wave elastography (SWE™) is a sonographic method for the detection of tissue stiffness by measuring the attenuation of a shear wave delivered perpendicular to the tissue [ 3 , 4 , 5 , 6 ] ( Figure 1 a). Several SWE tissue applications [ 4 , 7 ] in the muscle–skeletal system [ 8 ] and liver [ 9 , 10 , 11 ], as well as innovative applications in vessel imaging [ 12 ], the small intestine in Crohn’s disease [ 13 ], thyroid nodules [ 14 , 15 ], the prostate [ 16 ] and breast ultrasound [ 17 ], ought to improve the diagnostic yield of B-mode. SWE implements a technology of two crossing ultrasound waves to gain an unbiased and user-independent estimate of tissue elasticity, which is considered advantageous compared to the mechanical pressure-based strain-elastography (SE) method [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms

et al. 2022

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Purpose: Shear-wave elastography (SWE) measures tissue elasticity using ultrasound waves. This study proposes a histogram-based SWE analysis to improve breast malignancy detection. Methods: N = 22/32 (patients/tumors) benign and n = 51/64 malignant breast tumors with histological ground truth. Colored SWE heatmaps were adjusted to a 0–180 kPa scale. Normalized, 250-binned RGB histograms were used as image descriptors based on skewness and area under curve (AUC). The histogram method was compared to conventional SWE metrics, such as (1) the qualitative 5-point scale classification and (2) average stiffness (SWEavg)/maximal tumor stiffness (SWEmax) within the tumor B-mode boundaries. Results: The SWEavg and SWEmax did not discriminate malignant lesions in this database, p > 0.05, rank sum test. RGB histograms, however, differed between malignant and benign tumors, p < 0.001, Kolmogorov–Smirnoff test. The AUC analysis of histograms revealed the reduction of soft-tissue components as a significant SWE biomarker (p = 0.03, rank sum). The diagnostic accuracy of the suggested method is still low (Se = 0.30 for Se = 0.90) and a subject for improvement in future studies. Conclusions: Histogram-based SWE quantitation improved the diagnostic accuracy for malignancy compared to conventional average SWE metrics. The sensitivity is a subject for improvement in future studies.

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Multiparametric Ultrasound Evaluation of the Thyroid: Elastography as a Key Tool in the Risk Prediction of Undetermined Nodules (Bethesda III and IV)—Histopathological Correlation

Cited by 9 publications

References 13 publications

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Qualitative and Quantitative Diagnosis in Head and Neck Cancer

Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms

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