Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Boers, Tim; Braak, Sicco J.; Rikken, Nicole E. T.; Versluis, Michel; Manohar, Srirang

doi:10.1002/jcu.23430

Cited by 6 publications

(7 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the 2017 ACR TIRADS guidelines 3 assign scores based on five US features: nodule composition, echogenicity, shape, margins, and intranodular hyperechoic foci. However, the diagnosis of TNs is significantly influenced by the subjective nature of physician experience, leading to considerable variations in diagnostic accuracy and efficiency among hospitals and physicians of different seniority levels 4 . Additionally, there is substantial controversy surrounding the malignant risks associated with the category four classification of TNs.…”

Section: Introductionmentioning

confidence: 99%

Enhancing malignancy prediction in thyroid nodules: A multimodal ultrasound radiomics approach in TI‐RADS category 4 lesions

Li,

Zhou

et al. 2024

J of Clinical Ultrasound

View full text Add to dashboard Cite

PurposeTo explore the diagnostic value of intralesional and perilesional radiomics based on multimodal ultrasound (US) images in predicting the malignant ACR TIRADS 4 thyroid nodules (TNs).MethodsA total of 297 cases of TNs in patients who underwent preoperative thyroid grayscale US and shear wave elastography (STE) were enrolled (training cohort: n = 150, internal validation cohort: n = 77, external validation cohort: n = 70). Regions of interests (ROIs) were delineated on grayscale US images and STE images, and then an isotropic expansion of 1.0, 1.5, 2.0, 2.5, and 3.0 mm was applied. Predictive models were established using recursive feature elimination‐support vector machines (RFE‐SVM) based on radiomics features calculated by random forest.ResultsThe perilesional ROI1.5mm expansion achieved the highest area under curve (AUC) (AUC: 0.753 for grayscale US, 0.728 for STE; 95% confidence interval (CI): 0.664–0.743, 0.684–0.739, respectively). The joint model had the highest AUC values of 0.936 in the training dataset, 0.926 in internal dataset, and 0.893 in external dataset. The calibration curve showed good consistency and the decision curve indicated a greater clinical net benefit of the joint model.ConclusionJoint model containing perilesional radiomics (1.5 mm) had significant value in predicting the malignant ACR TIRADS 4 TNs.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhancing malignancy prediction in thyroid nodules: A multimodal ultrasound radiomics approach in TI‐RADS category 4 lesions

Li,

Zhou

et al. 2024

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

“…Hence, such interventions are often performed under conventional US or computed tomography (CT) assistance. For needle guidance in thyroid punctures, US has emerged as the primary modality 2 as it allows for real-time imaging of the anatomy, is widely available at a relatively low cost, and does neither expose the patient nor the physician to ionizing radiation. However, both US imaging and insertion of needle-shaped instruments are known to be expert tasks and require training 3 not always available to physicians who only occasionally perform such procedures.…”

Section: Introductionmentioning

confidence: 99%

Miniaturized electromagnetic tracking enables efficient ultrasound-navigated needle insertions

Seitel,

Groener,

Eisenmann

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Ultrasound (US) has gained popularity as a guidance modality for percutaneous needle insertions because it is widely available and non-ionizing. However, coordinating scanning and needle insertion still requires significant experience. Current assistance solutions utilize optical or electromagnetic tracking (EMT) technology directly integrated into the US device or probe. This results in specialized devices or introduces additional hardware, limiting the ergonomics of both the scanning and insertion process. We developed the first ultrasound (US) navigation solution designed to be used as a non-permanent accessory for existing US devices while maintaining the ergonomics during the scanning process. A miniaturized EMT source is reversibly attached to the US probe, temporarily creating a combined modality that provides real-time anatomical imaging and instrument tracking at the same time. Studies performed with 11 clinical operators show that the proposed navigation solution can guide needle insertions with a targeting accuracy of about 5 mm, which is comparable to existing approaches and unaffected by repeated attachment and detachment of the miniaturized tracking solution. The assistance proved particularly helpful for non-expert users and needle insertions performed outside of the US plane. The small size and reversible attachability of the proposed navigation solution promises streamlined integration into the clinical workflow and widespread access to US navigated punctures.

show abstract

“…8,9 Moreover, when the target site is surrounded by critical structures, taking into account safety margins is required to minimize the damage to these viable tissues. 7,8 There is a need and an ongoing effort 10,11 to improve current approaches in needle-based diagnosis and interventions on thyroid nodules. Testing and iterative optimization of the technique is not possible directly on patients, due to its burden and due to ethical considerations.…”

Section: Introductionmentioning

confidence: 99%

“…There is a need and an ongoing effort 10,11 to improve current approaches in needle‐based diagnosis and interventions on thyroid nodules. Testing and iterative optimization of the technique is not possible directly on patients, due to its burden and due to ethical considerations.…”

Section: Introductionmentioning

confidence: 99%

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Boers,

Brink,

Bianchi

et al. 2023

Medical Physics

Self Cite

View full text Add to dashboard Cite

BackgroundNeedle‐based procedures, such as fine needle aspiration and thermal ablation, are often applied for thyroid nodule diagnosis and therapeutic purposes, respectively. With blood vessels and nerves nearby, these procedures can pose risks in damaging surrounding critical structures.PurposeThe development and validation of innovative strategies to manage these risks require a test object with well‐characterized physical properties. For this work, we focus on the application of ultrasound‐guided thermal radiofrequency ablation.MethodsWe have developed a single‐use anthropomorphic phantom mimicking the thyroid and surrounding anatomical and physiological structures that are relevant to ultrasound‐guided thermal ablation. The phantom was composed of a mixture of polyacrylamide, water, and egg white extract and was cast using molds in multiple steps. The thermal, acoustical, and electrical characteristics were experimentally validated. The ablation zones were analyzed via non‐destructive T2‐weighted magnetic resonance imaging scans utilizing the relaxometry changes of coagulated egg albumen, and the temperature distribution was monitored using an array of fiber Bragg grating sensors.ResultsThe physical properties of the phantom were verified both on ultrasound as well as in terms of the phantom response to thermal ablation. The final temperature achieved (92°C), the median percentage of the nodule ablated (82.1%), the median volume ablated outside the nodule (0.8 mL), and the median number of critical structures affected (0) were quantified.ConclusionAn anthropomorphic phantom that can provide a realistic model for development and training in ultrasound‐guided needle‐based thermal interventions for thyroid nodules has been presented.

show abstract

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Cited by 6 publications

References 140 publications

Enhancing malignancy prediction in thyroid nodules: A multimodal ultrasound radiomics approach in TI‐RADS category 4 lesions

Enhancing malignancy prediction in thyroid nodules: A multimodal ultrasound radiomics approach in TI‐RADS category 4 lesions

Miniaturized electromagnetic tracking enables efficient ultrasound-navigated needle insertions

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Contact Info

Product

Resources

About