Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications

Novel diazabicycloalkane delta opioid agonists

“…[25][26][27][28][29][30] Although the development of SNC80 as first synthetic d agonist drug candidate was interrupted principally for evidences of convulsive effects exerted by its administration, 31 the appearance of these adverse effects have been reviewed 32 and the interest in d opioid agonist development has been recently revamped. [33][34][35][36][37] Particularly, interesting behaviours have been reported in the last years on the selective d opioid agonists KNT-127, 38 ADL5747, 39 AZD2327, 40 and AZD7268 41 (Fig. 1).…”