Multinucleate cell angiohistiocytoma: a new case report

Barrios, Susana Blanco; Diaz, Eloy Rodríguez; Cuesta, César Cosme Álvarez; Osuna, Cristina Galache; Caballero, Celia Requena; Merino, Antonio; Caballero, Luis; Kutzner, Heinz

doi:10.1111/j.1468-3083.2005.00983.x

Cited by 17 publications

(16 citation statements)

References 13 publications

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“…23 Furthermore, it usually arises on the extremities as discrete grouped violaceous papules and does not have any tendency to resolve. 23,24 In contrast to Kaposi sarcoma, in our case, HHV8 immunoreaction was negative and well-formed vessels without evidence of promontory sign were observed. Glomeruloid hemangioma was ruled out because it is usually associated to POEMS (polineuropathy, organomegaly, endocrine abnormality, Mprotein, plasma cell dyscrasia, skin lesions) syndrome as small red papules in which dilated dermal vascular spaces are filled with aggregates of small vessels.…”

Section: Discussioncontrasting

confidence: 78%

Cutaneous Reactive Angiomatosis Associated With Chronic Lymphoid Leukemia

Mariñas

Vidaurrazaga²,

Burgos-Bretones³

et al. 2008

The American Journal of Dermatopathology

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Cutaneous reactive angiomatosis is an unusual benign vascular disorder of the skin usually associated to systemic diseases. It is characterized by lobular or diffuse proliferation of small blood vessels with hyperplasia of endothelial cells, pericytes, and sometimes histiocytes. We report a 59-year-old man with asymptomatic erythematous-violaceous patches on back, palms, and elbows for 9 months. Laboratory examination revealed changes consistent with B-chronic lymphocytic leukemia. Cutaneous biopsy showed a predominantly lobular small blood vessel proliferation in dermis with pericytic hyperplasia and mild perivascular lymphoplasmacytic infiltrate. Spontaneous involution of lesions occurred after 6 months. A second biopsy performed at the beginning of clinical involution showed a less prominent vascular component with perivascular giant cells with coexpression of CD68 and CD 31. To our knowledge, this is the first case of cutaneous reactive angiomatosis with documented histopathological findings of clinical involution.

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Section: Discussioncontrasting

confidence: 78%

Cutaneous Reactive Angiomatosis Associated With Chronic Lymphoid Leukemia

Mariñas

Vidaurrazaga²,

Burgos-Bretones³

et al. 2008

The American Journal of Dermatopathology

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“…Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft‐tissue tumour, first described by Smith and Wilson‐Jones 1 . Although an overwhelming majority of these tumours have been described on the skin of the limbs, 2–8 lesions have also been diagnosed on the skin of the temple, 5 chest, 6 face and trunk, 7 eyelid 9 and vermilion of the lip 10 . To our knowledge, this is the first report of a mucosal MCAH.…”

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confidence: 89%

“…MCAH is more commonly seen in women. The skin on the limbs is most commonly affected, 2–8 but lesions affecting the face, 7 chest, 6 trunk, 7 temple, 5 lip, 10 and eyelid 9 have also been described. The differential diagnosis includes nodular, lichen planus, lymphocytic infiltrates, annular sarcoid granuloma, angiohistiocytoma, Kaposi’s and pseudo‐Kaposi’s sarcomas.…”

Section: Reportmentioning

confidence: 99%

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Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour

Rawal¹,

Anderson²,

Rawal

2009

Clinical and Experimental Dermatology

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Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft-tissue lesion with characteristic histological and immunohistochemical features. It is unclear if it represents a benign neoplasm or a reactive/inflammatory process. The overwhelming majority of these tumors have been described on cutaneous surfaces. One case has been reported on the skin of the lip. This is the first documentation of MCAH within the oral cavity. The clinical presentation, histopathological features and immunohistochemical reactivity pattern are described. Because of the benign nature of this lesion, a conservative approach is recommended in its management. Surgical excision appears to be curative.

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“…[2][3][4][5][6][7][8][9][10] MCAH is more frequent in elderly women than in men, suggesting that hormones can have a role in the pathogenesis of this entity. The typical clinical features consist of a cluster of red to violaceous papules or plaques, ranging in size from few millimetres to 1.5 cm, located on a single anatomical area as lower extremities, dorsum of the hands, wrists, fingers or face.…”

Section: Introductionmentioning

confidence: 99%

Linear and Bilateral Multinucleated Cell Angiohistiocytoma (MCAH)

Coco

Guerriero

Stefani

et al. 2017

J Dermatol Case Rep

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Background: Multinucleated Cell Angiohistiocytoma (MCAH) is a rare disease, first described by Smith and Wilson Jones in 1985. Since then, less than 100 cases have been reported in the literature. Clinically it is characterized by papules or plaques arising from a specific anatomical area such as lower extremities, dorsum of the hands and face. Some generalized cases have been reported. Main observations:We report a case of 77-year-old woman who presented with multiple itching. reddish to violaceous, flat to domed-shaped plaques on the lower legs with symmetrical and bilateral distribution along the saphena veins. On dermoscopy examination only a red-violaceous homogeneous area was visible. Histology showed remarkable proliferation of dilated small vessels in the upper and mid dermis and bizarre-shaped multinucleate giant cells with scalloped cytoplasm that were intermingled with numerous mononucleated spindle cells. Many mast cells containing the characteristic granules were also detected, often adjacent to the multinucleate cells. Based on the clinico-pathologic findings the diagnosis of MCAH was established. Conclusions:To our knowledge, this is the first documented case of MCAH with a bilateral and linear pattern disposed on the lower limbs, following the saphena veins. In this patient chronic trauma induced by ambulation might have contributed to development of the lesions. (J Dermatol Case Rep. 2016; 10(4) MCAH is more frequent in elderly women than in men, suggesting that hormones can have a role in the pathogenesis of this entity. The typical clinical features consist of a cluster of red to violaceous papules or plaques, ranging in size from few millimetres to 1.5 cm, located on a single anatomical area as lower extremities, dorsum of the hands, wrists, fingers or face. The lesions can be arranged in an annular configuration or grouped in a cluster and are usually asymptomatic but may be rarely itchy. The clinical differential diagnoses may include dermatofibroma, angiofibroma, Kaposi sarcoma, pseudo-Kaposi sarcoma, granuloma anulare, lichen planus, pyogenic granuloma, giant-cell fibroblastoma, sarcoidosis and insect bite. Case ReportWe report a 77-year-old woman who presented with a 5-year history of multiple papules on the lower extremities. The patient reported that the first lesion appeared after a holiday and it was initially diagnosed as a mosquito bite. With time the lesion did not regress and new similar lesions occurred at the same site. Treatment with argon laser, performed by another institution, was unsuccessful. Physical examination showed multiple itching reddish to violaceous, flat to domed-shaped plaques on the lower legs with an unusual DOI: http://dx.doi.org/10.3315/jdcr.2016.1237 58 symmetrical and bilateral distribution along the saphena veins (Fig. 1). The overall lesions count was 38 and the size varied from 6 to 13 mm. Clinical diagnoses included Kaposi sarcoma, dermatofibroma and angiofibroma.On dermoscopy examination we observed no specific clues for the diagnosis. Only a...

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Multinucleate cell angiohistiocytoma: a new case report

Cited by 17 publications

References 13 publications

Cutaneous Reactive Angiomatosis Associated With Chronic Lymphoid Leukemia

Cutaneous Reactive Angiomatosis Associated With Chronic Lymphoid Leukemia

Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour

Linear and Bilateral Multinucleated Cell Angiohistiocytoma (MCAH)

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