Multinucleate cell angiohistiocytoma: a case report and review of the literature.

Applebaum, Danielle S.; Shuja, Fareesa; Hicks, Lindsey D.; Cockerell, Clay J.; Hsu, Sylvia

doi:10.5070/d3205022610

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…Surgery, 3 cryotherapy, 12 CO2 laser, 13,14 and vascular lasers 15 -22 have been successfully used. Other therapies such as topical or intralesional corticosteroids did not show effectiveness.…”

Section: Discussionmentioning

confidence: 99%

“…Therapy intervention is indicated if MCAH causes itching or an esthetic problem. Surgery, 3 cryotherapy, 12 CO2 laser, 13,14 and vascular lasers [15][16][17][18][19][20][21][22] have been successfully used. Other therapies such as topical or intralesional corticosteroids did not show effectiveness.…”

Section: Discussionmentioning

confidence: 99%

“…23 In 1995, Kopera et al published the first two patients with MCAH treated with argon laser. 15 Since then, some case reports of MCAH treated with other lasers have been published: ablative CO2 laser, 13,14 IPL, 3,6 and more recently PDL, 17,18 Nd:YAG [19][20][21] and potassium-titanyl-phosphate (KTP) laser in combination with intralesional corticosteroids. 22 Vascular lasers are useful in treating MCAH since they have their target in the oxyhemoglobin inside vessels.…”

Section: Discussionmentioning

confidence: 99%

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Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature

et al. 2023

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Background Multinucleate cell angiohistiocytoma (MCAH) is an unusual fibrohistiocytic proliferation in the dermis with vascular hyperplasia. Numerous clinicopathological studies of MCAH have been published, but little has been written in relation to treatment. Objectives The aim of the present study is to review the therapeutical approaches for MCAH in the literature and to report the results of the different therapies followed at our institution. Methods A literature review was conducted including all MCAH published cases that followed any therapy. Search terms included “multinucleate cell angiohistiocytoma” or “MCAH” and “treatment” or “therapy”. Also, all cases of MCAH treated at our institution from 2010 to 2020 are reported. Results The literature search revealed 16 cases of MCAH treated with any of the therapeutic options. At our institution, 9 patients have been treated of MCAH between 2010 and 2020. Over 75% of them were female, and the median age was 56 years (range 47-73). More than 50% had lesions on the dorsum of the hands. Surgical excision was indicated in 2 patients, ablative CO2 laser was used in 1 patient and the 6 remaining ones followed vascular-targeted therapies (PDL and IPL). A satisfactory cosmetic result was achieved in all of them. Conclusions We propose PDL therapy as a first-line treatment for MCAH since it achieves satisfactory esthetic results, while being well-tolerated. Selecting those amenable patients according to morphologic characteristics may be useful to avoid unsuccessful therapies. In MCAH with predominant fibrous stroma, surgery or CO2 laser may be the best option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature

et al. 2023

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“…7 The clinical presentation is peculiar, with multiple unilateral grouped asymptomatic papules. Atypical clinical presentations have also been described, including bilateral forms, 8,9 with smooth or flat lesions, 10 generalized forms, 8 presentation in children, 11 or locations other than acral, such as the trunk, or mucosal membranes. 8,12,13 Although the lesions are reddish, pink, or violaceous in most cases, brown pigmented lesions have been occasionally reported.…”

Section: Discussionmentioning

confidence: 99%

Pigmented Multinucleate Cell Angiohistiocytoma: First Case

Fernández-Flores

2022

The American Journal of Dermatopathology

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Multinucleate cell angiohistiocytoma (MCAH) is a benign vascular and fibrohistiocytic (probably reactive) proliferation with peculiar multinucleate cells which most authors interpret as degenerated macrophages. Several clinical variants of MCAH have been described, some of them with brownish-appearing lesions clinically. However, no histologically identified pigment has been described in the cytoplasm of the multinucleate cells so far. We present a pigmented MCAH with cytoplasmic brownish pigment, which was positive with a Masson-Fontana stain and negative with an iron stain, consistent with melanin, in a 33-year-old woman with multiple papules and plaques on the right elbow, right jawline, and left flank.

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“…4 El estudio histológico es diagnóstico con los siguientes hallazgos: proliferación de vasos capilares y vénulas en la dermis superficial y media, cuyo endotelio es prominente y en ocasiones protruye hacia la luz, células multinucleadas que presentan citoplasma angulado con núcleos hipercromáticos en número variable, inmersas en un estroma fibroso. 10,11 En la inmunohistoquímica, como es esperado, las células endoteliales expresan factor VIII, CD31 y CD34, mientras que los macrófagos, histiocitos y células multinucleadas expresan factor XIIIa, CD68 (variable) y vimentina. 5 La dermatoscopía hasta el momento es inespecífica.…”

Section: Introductionunclassified

Angiohistiocitoma de células multinucleadas

Navarrete-Franco¹,

González-González²,

Ramos-Garibay³

et al. 2022

Revista Del Centro Dermatológico Pascua

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El angiohistiocitoma de células multinucleadas (AHCMN) es una proliferación vascular y fibrohistiocítica de origen aún incierto. Descrito por primera vez por Smith y Wilson-Jones en 1985, es una dermatosis poco frecuente; la forma clásica afecta sobre todo a mujeres de edad media y suele presentarse de forma unilateral, afectando con frecuencia regiones acrales y cara. Morfológicamente son neoformaciones numerosas, cupuliformes, de superficie lisa, eritematosas, eritematovioláceas y/o marrón, aisladas y/o confluentes, formando placas de forma y tamaño variable. Se han descrito casos diseminados con características epidemiológicas y morfológicas diferentes. El diagnóstico se basa en los hallazgos histopatológicos, que incluyen proliferación vascular capilar en la dermis superficial con presencia de células multinucleadas inmersas en un estroma fibroso. El cuadro evoluciona en forma lenta y tiende a ser persistente; aunque existen casos de involución espontánea. El tratamiento de elección es la extirpación quirúrgica, cuando es posible, y la vigilancia es una alternativa ante la naturaleza benigna de esta entidad.Palabras clave: angiohistiocitoma de células multinucleadas.

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Multinucleate cell angiohistiocytoma: a case report and review of the literature.

Cited by 10 publications

References 11 publications

Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature

Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature

Pigmented Multinucleate Cell Angiohistiocytoma: First Case

Angiohistiocitoma de células multinucleadas

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