Multinuclear NMR and crystallographic study of diorganotin valproates – Part II

Spectroscopic and X‐ray structural characterization of new polymeric organotin(IV) carboxylates and their in vitro antifungal activities: Part II

“…1 H NMR and 13 C{ 1 H} NMR data for 1 – 3 , summarized in Table , occurred in the typical regions for the 4‐phenylbutyrate (Scheme ) . The 2 J ( 119 Sn– 1 H) value (59.4 Hz) observed for 1 is smaller than that measured for the tetranuclear species [{(Me 2 SnOPh b ) 2 O} 2 ] (87.3 Hz) .…”

“…From the FT‐IR spectroscopy viewpoint, the symmetric and asymmetric COO stretching modes are important for analysis of the Sn–carboxyl coordination. These vibration modes are normally observed as strong bands in the FT‐IR spectra of organotin(IV) carboxylates . The Δ ν (COO) = ( ν as − ν s ) value constitutes a spectroscopic means to determine whether the Sn–carboxyl coordination is bidentate or bridging: Δ ν (COO) < 200 cm −1 ; or monodentate: Δ ν (COO) > 200 cm −1 .…”

“…Besides preparing new organotin derivatives and investigating their biocidal activity against some microorganisms, we have been interested in the pharmacological mechanisms of such complexes. We have recently reported the synthesis, spectroscopic and X‐ray structural characterization of organotin(IV) valproate complexes and discrete diorganotin(IV) coordination entities bearing the 4‐phenylbutanoate anion, Ph(CH 2 ) 3 CO 2 − ( − OPh b ), namely [{(Me 2 SnOPh b ) 2 O} 2 ], [Bu 2 Sn(OPh b ) 2 ] and [{PhSn(O)OPh b } 6 ] . As part of our ongoing interest in organotin carboxylates, we herein describe the preparation and spectroscopic properties of three polymeric triorganotin(IV) carboxylates, namely [R 3 Sn(OPh b )] n (R = Me ( 1 ), Bu ( 2 ) or Ph ( 3 )), as well as their antifungal activities against a variety of Candida microorganisms.…”