Multinodular and vacuolating neuronal tumor: A case report and literature review

Abstract

Background:Multinodular and vacuolated neuronal tumor (MVNT) is a benign neuronal tumor that is newly recognized as architectural appearance that may be related to ganglion cell tumors in 2016 World Health Organization Classification of Tumors of the Central Nervous System. Herein, we report a case of MVNT in a 60-year-old man with a thorough literature review.Case Description:A 60-year-old male was pointed out the presence of intracerebral neoplasm located in left frontal lobe by a comprehensive medical examination. We suspected dysembryoplastic neuroepithelial tumors and proposed him to wait and see, but he wished to undergo surgery for diagnosis. We performed en bloc resection and pathological findings were consistent with MVNT. He was discharged on the 8th day after the operation without any complications. He remained stable without recurrence at the 16-month postoperative follow-up.Conclusions:Further studies may be helpful to fully understand the radiological and histological findings of MVNT development. As a result, we will be able to prevent the aggressive treatment if we established their major features.

Multinodular and Vacuolating Neuronal Tumor: Incidental Diagnosis of a Rare Brain Lesion

“…First reported in 2013, MVNTs are sporadic benign brain tumors [ 1 , 3 , 6 ]. MVNTs have been associated with ganglion cell tumors found in the cortical white matter [ 3 ].…”

“…In 2016, MVNT was classified by the World Health Organization Classification of Tumors of the Central Nervous System [ 2 ]. Most of the MVNT cases reported yet have been in middle-aged patients with neurological symptoms including headaches and seizures [ 3 - 6 ]. Surgical intervention is often indicated in MVNTs related to epileptic symptoms [ 3 - 6 ].…”

“…Most of the MVNT cases reported yet have been in middle-aged patients with neurological symptoms including headaches and seizures [ 3 - 6 ]. Surgical intervention is often indicated in MVNTs related to epileptic symptoms [ 3 - 6 ]. However, asymptomatic cases of MVNT have rarely been reported, suggesting MVNT may go undiagnosed, and therefore surgical intervention is infrequently necessary [ 5 ].…”

Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient

“…Recent report, however, described that epilepsy was found in only 8 of 33 cases of MVNT confirmed pathologically or suspected by MRI (Nunes et al, 2017). A recent case study presented a pathologically confirmed MVNT without any neurological symptoms (Shitara et al, 2018). The authors argued that MVNT may be a “leave me alone” lesion and that it does not necessarily require invasive evaluation and treatment; it is mostly asymptomatic and does not manifest enlargement during its clinical course (Nunes et al, 2017).…”

Advanced multiparametric magnetic resonance imaging of multinodular and vacuolating neuronal tumor

“…Multinodular and vacuolating neuronal tumors have been reported to display highly suggestive imaging features, especially on magnetic resonance imaging (MRI) [3‐13]. An MVNT consists of the coalescence of small T2‐weighted imaging and fluid‐attenuated inversion recovery (FLAIR) hyperintense nodules in subcortical and juxtacortical areas, with rare or no post‐contrast enhancement.…”