Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient

Kodama, Satoshi; Shirota, Yasuhiko; Hagiwara, Akifumi; Otsuka, Juuri; Sato, Ken-ichi; Sugiyama, Yusuke; Mori, Hiromu; Watanabe, Miki; Hamada, Masayuki; Toda, Tatsushi

doi:10.1016/j.cnp.2019.05.003

Cited by 3 publications

(3 citation statements)

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“…Previously, MVNT with no neurological symptoms was reported in a 60-year-old man [ 6 ]. Additionally, MVNT was reported in a 33-year-old female diagnosed with epilepsy following an episode of limbic encephalitis two years prior [ 5 ]. In that case, the tumor was identified because of the patient’s seizures, localized to the temporal lobe; however, it was concluded that the seizures were unrelated to the MVNT [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, MVNT was reported in a 33-year-old female diagnosed with epilepsy following an episode of limbic encephalitis two years prior [ 5 ]. In that case, the tumor was identified because of the patient’s seizures, localized to the temporal lobe; however, it was concluded that the seizures were unrelated to the MVNT [ 5 ]. Consistent with the previous reports, our patient’s MVNT showed no change on imaging at three-month, six-month, and one-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical intervention is often indicated in MVNTs related to epileptic symptoms [ 3 - 6 ]. However, asymptomatic cases of MVNT have rarely been reported, suggesting MVNT may go undiagnosed, and therefore surgical intervention is infrequently necessary [ 5 ]. Here we present the case of a 25-year-old female patient with incidental finding of an MVNT with no neurologic deficits.…”

Section: Introductionmentioning

confidence: 99%

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Multinodular and Vacuolating Neuronal Tumor: Incidental Diagnosis of a Rare Brain Lesion

Arbuiso¹,

Roster²,

Gill³

et al. 2021

Cureus

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Multinodular and vacuolating neuronal tumor (MVNT) is a rare benign brain lesion, commonly found in middle-aged adults. The patients experience a range of symptoms from being asymptomatic to epileptic seizures, with headache being the most common symptom. Here we report a case of an incidental diagnosis of MVNT in a young female. A 25-year-old female with a past medical history of occasional headaches without seizures or any focal neurological deficit presented after a motor vehicle rollover. The MRI brain revealed an incidental finding of a subcortical lesion in the right parietal lobe with T2-FLAIR (fluid-attenuated inversion recovery) hyperintensity between the cystic portions, indicative of a possible MVNT, with a less probable chance of dysembryoplastic neuroepithelial tumor based on the subcortical location of the lesion. No neurosurgical intervention was recommended. With one-year follow-up, no changes were noted on neuroimaging, and the patient remained stable without any neurological symptoms. The MVNT is a rare brain lesion that presents with benign features. In patients with epileptic symptoms, surgical resection of the lesion can be curative. However, in asymptomatic patients, careful monitoring may be sufficient, as described in this case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multinodular and Vacuolating Neuronal Tumor: Incidental Diagnosis of a Rare Brain Lesion

Arbuiso¹,

Roster²,

Gill³

et al. 2021

Cureus

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Multinodular and Vacuolating Neuronal Tumour (MVNT)

Vavro

2021

Neuroradiology - Images vs Symptoms

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Neuroradiological and pathomorphological features of epilepsy associated brain tumors

Khalilov¹,

Холин²,

Кисляков³

et al. 2021

Lučevaâ diagn. ter.

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Brain tumors are the second most common etiology in pediatric patients with focal seizures undergoing surgery for drug-resistant epilepsy. These neoplasms have a number of distinctive features from those found in adult patients, one of which is a wide polymorphism of structural architectonics during neuroradiological examination. Given the tremendous biological stability of these tumors, not in all cases of pre-surgical examination it is possible to verify the presence of a neoplastic process in the structure of the epileptogenic substrate using routine neuroimaging methods. In some complex diagnostic cases, a multimodal imaging approach and in-depth complex examination are required for reliable diagnosis and success of the results of epileptic surgery.

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Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient

Abstract: HighlightsMultinodular vacuolating neuronal tumor (MVNT) was initially reported as epilepsy-related brain tumor.MVNT can exist as incidental and asymptomatic lesions in some cases.It is not always necessary to perform surgical resection of MVNT even in patients with epilepsy.

Cited by 3 publications

References 10 publications

Multinodular and Vacuolating Neuronal Tumor: Incidental Diagnosis of a Rare Brain Lesion

Multinodular and Vacuolating Neuronal Tumor: Incidental Diagnosis of a Rare Brain Lesion

Multinodular and Vacuolating Neuronal Tumour (MVNT)

Neuroradiological and pathomorphological features of epilepsy associated brain tumors

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