Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Ediage, Emmanuel Njumbe; Mavungu, José Diana Di; Song, Suquan; Sioen, Isabelle; Saeger, Sarah De

doi:10.1016/j.envint.2013.04.002

Cited by 83 publications

(48 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean probabilistic exposure assessment results of individual mycotoxin were similar to the deterministic values, and also comparable to that reported from northern Nigeria (Ezekiel et al, 2014), Cameroon (Njumbe Ediage et al, 2014), Belgium (Harcz et al, 2007) and Japan (Nakatani et al, 2011).…”

Section: Probabilistic Analysissupporting

confidence: 87%

Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China

Han

Nie

Ediage

et al. 2014

Food and Chemical Toxicology

Self Cite

View full text Add to dashboard Cite

Section: Probabilistic Analysissupporting

confidence: 87%

Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China

Han

Nie

Ediage

et al. 2014

Food and Chemical Toxicology

Self Cite

View full text Add to dashboard Cite

“…Several pilot-scale studies applying multibiomarker Electronic supplementary material The online version of this article (doi:10.1007/s12550-015-0223-9) contains supplementary material, which is available to authorized users. approaches to investigate exposure of populations in Africa, Asia, or Europe have revealed regional differences in urinary biomarker excretion patterns (Warth et al 2014;Njumbe Ediage et al 2013;Gerding et al 2014;Abia et al 2013). Differences in nutritional habits and quality of consumed foodstuffs are likely the reason for interregional variations in mycotoxin excretion.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach

et al. 2015

View full text Add to dashboard Cite

An improved "dilute and shoot" LC-MS/MS multibiomarker approach was used to monitor urinary excretion of 23 mycotoxins and their metabolites in human populations from Asia (Bangladesh), Europe (Germany), and the Caribbean region (Haiti). Deoxynivalenol (DON), deoxynivalenol-3-glucuronide (DON-3-GlcA), T-2-toxin (T-2), HT-2-toxin (HT-2), HT-2-toxin-4-glucuronide (HT-2-4-GlcA), fumonisin B1 (FB1), aflatoxins (AFB1, AFB2, AFG1, AFG2, AFM1), zearalenone (ZEA), zearalanone (ZAN), their urinary metabolites α-zearalanol (α-ZEL) and β-zearalanol (β-ZEL), and corresponding 14-O-glucuronic acid conjugates (ZEA-14-GlcA, ZAN-14-GlcA, β-ZEL, α/β-ZEL-14-GlcA), ochratoxin A (OTA), and ochratoxin alpha (OTα) as well as enniatin B (EnB) and dihydrocitrinone (DH-CIT) were among these compounds. Eight urinary mycotoxin biomarkers were detected (AFM1, DH-CIT, DON, DON-GLcA, EnB, FB1, OTA, and α-ZEL). DON and DON-GlcA were exclusively detected in urines from Germany and Haiti whereas urinary OTA and DH-CIT concentrations were significantly higher in Bangladeshi samples. AFM1 was present in samples from Bangladesh and Haiti only. Exposure was estimated by the calculation of probable daily intakes (PDI), and estimates suggested occasional instances of toxin intakes that exceed established tolerable daily intakes (TDI). The detection of individual mycotoxin exposure by biomarker-based approaches is a meaningful addition to the classical monitoring of the mycotoxin content of the food supply.

show abstract

“…Potential mycotoxin exposure through maize consumption has been identified to be higher in rural areas of developing countries where vulnerable consumers utilize broken and damaged kernels for diverse dietary purposes; such kernels are usually cheaper but could possibly be higher in mycotoxin content (Abia et al, 2013b; Njumbe Ediage et al, 2013; Adetunji et al, 2014b; Ezekiel et al, 2014). Efforts toward diversification of maize meals for enhanced nutritional benefits led to ogi production involving fermentation steps.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Diversity and Mycotoxin Reduction During Maize Fermentation (Steeping) for Ogi Production

et al. 2015

View full text Add to dashboard Cite

Bacterial diversity and community structure of two maize varieties (white and yellow) during fermentation/steeping for ogi production, and the influence of spontaneous fermentation on mycotoxin reduction in the gruel were studied. A total of 142 bacterial isolates obtained at 24–96 h intervals were preliminarily identified by conventional microbiological methods while 60 selected isolates were clustered into 39 OTUs consisting of 15 species, 10 genera, and 3 phyla by 16S rRNA sequence analysis. Lactic acid bacteria constituted about 63% of all isolated bacteria and the genus Pediococcus dominated (white maize = 84.8%; yellow maize = 74.4%). Pediococcus acidilactici and Lactobacillus paraplantarum were found at all steeping intervals of white and yellow maize, respectively, while P. claussenii was present only at the climax stage of steeping white maize. In both maize varieties, P. pentosaceus was found at 24–72 h. Mycotoxin concentrations (μg/kg) in the unsteeped grains were: white maize (aflatoxin B1 = 0.60; citrinin = 85.8; cyclopiazonic acid = 23.5; fumonisins (B1/B2/B3) = 68.4–483; zearalenone = 3.3) and yellow maize (aflatoxins (B1/B2/M1) = 22.7–513; citrinin = 16,800; cyclopiazonic acid = 247; fumonisins (B1/B2/B3) = 252–1,586; zearalenone = 205). Mycotoxins in both maize varieties were significantly (p < 0.05) reduced across steeping periods. This study reports for the first time: (a) the association of L. paraplantarum, P. acidilactici, and P. claussenii with ogi production from maize, (b) citrinin occurrence in Nigerian maize and ogi, and (c) aflatoxin M1, citrinin and cyclopiazonic acid degradation/loss due to fermentation in traditional cereal-based fermented food.

show abstract

Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Cited by 83 publications

References 48 publications

Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China

Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China

A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach

Bacterial Diversity and Mycotoxin Reduction During Maize Fermentation (Steeping) for Ogi Production

Contact Info

Product

Resources

About