Multimorbidity in COPD, does sleep matter?

Vanfleteren, Lowie E.G.W.; Beghè, Bianca; Andersson, Anders; Hansson, Daniel; Fabbri, Leonardo M.; Grote, Ludger

doi:10.1016/j.ejim.2019.12.032

Cited by 24 publications

(22 citation statements)

References 117 publications

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“…At present, COPD is one of the major public health problems in the world, and it is expected to be the fourth leading cause of death in the world by 2030 [20,21]. It's been estimated that more than 390 million people may have COPD in 2030 [22]. The pathophysiological changes of COPD include the involvement of lung parenchyma and pulmonary blood vessels [23].…”

Section: Discussionmentioning

confidence: 99%

The CT pulmonary vascular parameters and disease severity in COPD patients on acute exacerbation: a correlation analysis

Yang

Chen

2021

BMC Pulm Med

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Background It is necessary to analyze the CT pulmonary vascular parameters and disease severity in chronic obstructive pulmonary disease (COPD) patients to provide evidence support for the management of COPD. Methods COPD patients on acute exacerbation admitted to our hospital from COPD patients from January 2019 to March 2020 was selected. The characteristics and ratio of the cross-sectional area (CSA) of small pulmonary vessels to the total area of the lung field, and the ratio of pulmonary artery and aorta (PA/A) cross-sectional diameter in patients with COPD were analyzed. Results A total of 128 COPD patients were included. There were significant differences in the duration of COPD, smoking history, the PaO2, PaCO2, pH, and FEV1, FVC and FEV1/FVC among COPD patients with different severity (all p < 0.05). The duration of COPD, smoking, PaO2, PaCO2, CSA and PA/A were correlated with the COPD severity (all p < 0.05). Both CSA, PA/A were correlated with post BD FEV1 (all p < 0.05). The cutoff value of CSA and PA/A for the diagnosis of severe COPD was 0.61 and 0.87 respectively, and the AUC of CSA and PA/A for the diagnosis of severe COPD was 0.724 and 0.782 respectively. Conclusions Patients with CSA ≤ 0.61 and PA/A ≥ 0.87 may have higher risks for severe COPD, and more studies are needed in the future to further elucidate the management of COPD.

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Section: Discussionmentioning

confidence: 99%

The CT pulmonary vascular parameters and disease severity in COPD patients on acute exacerbation: a correlation analysis

Yang

Chen

2021

BMC Pulm Med

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“…49 The link between sleep disorders, depression and anxiety in COPD has already been proven earlier and replicated in the exploratory analysis of this current study. 50,51 Further, sleep disturbances in COPD can also be associated with cognitive deficits. 25 We revealed the possibility of such a relationship only among men with COPD -in their case, dementia was included in both factor matrices (along both neurological and psychiatric conditions).…”

Section: The Pattern Of Psychiatric and Sleep Comorbiditiesmentioning

confidence: 99%

Neurological and Psychiatric Comorbidities in Chronic Obstructive Pulmonary Disease

Puteikis¹,

Mameniškienė²,

Jurevičienė³

2021

COPD

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Background and Purpose Chronic obstructive pulmonary disease (COPD) is often accompanied by different neurological and psychiatric comorbidities. The purpose of this study was to examine which of them are the most frequent and to explore whether their manifestation can be explained by underlying latent variables. Methods Data about patients with COPD and their neurological and psychiatric comorbidities were extracted from an electronic database of the National Health Insurance Fund of Lithuania for the period between January 1, 2012, and June 30, 2014. Exploratory factor analysis (EFA) was used to investigate comorbidity patterns. Results A study sample of 4834 patients with COPD was obtained from the database, 3338 (69.1%) of who were male. The most frequent neurological and psychiatric comorbidities were nerve, nerve root and plexus disorders (n=1439, 29.8%), sleep disorders (n=666, 13.8%), transient ischemic attack (n=545, 11.3%), depression (n=364, 7.5%) and ischemic stroke (n=349, 7.2%). The prevalence of ischemic stroke, transient ischemic attack, Parkinson’s disease, dementia and sleep disorders increased with age. One latent variable outlined during EFA grouped neurological disorders, namely ischemic stroke, transient ischemic attack, epilepsy, dementia and Parkinson’s disease. The second encompassed depression, anxiety, somatoform and sleep disorders. While similar patterns emerged in data from male patients, no clear comorbidity profiles among women with COPD were obtained. Conclusion Our study provides novel insights into the neurological and psychiatric comorbidities in COPD by outlining an association among cerebrovascular, neurodegenerative disorders and epilepsy, and psychiatric and sleep disorders. Future studies could substantiate the discrete pathological mechanism that underlie these comorbidity groups.

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“…Chronic diseases that have been reported to be more prevalent in patients with COPD, and that have an impact on severity and prognosis. (fatigue and reduced physical activity), and sleep disorders (fatigue) 52 . In addition, comorbidities are common at any severity of COPD 53 , and the differential diagnosis can often be difficult.…”

Section: Comorbidities Of Copdmentioning

confidence: 99%