From systemic effects of COPD to COPD as pulmonary component of multimorbidity

Vanfleteren, Lowie E.G.W.; Vikjord, Sigrid Aa; Ingvar, Martin; Fabbri, Leonardo

doi:10.23866/brnrev:2019-0004

Cited by 2 publications

(2 citation statements)

References 101 publications

(141 reference statements)

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“…Comorbidities not only increase the burden that people with COPD suffer but decrease quality of life [ 18 ]. COPD should be considered as the pulmonary component of multimorbidity [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Chronic Obstructive Pulmonary Disease (COPD) Comorbidities in Lithuanian National Database: A Cluster Analysis

Jurevičienė

Burneikaitė

Dambrauskas

et al. 2022

IJERPH

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Various comorbidities and multimorbidity frequently occur in chronic obstructive pulmonary disease (COPD), leading to the overload of health care systems and increased mortality. We aimed to assess the impact of COPD on the probability and clustering of comorbidities. The cross-sectional analysis of the nationwide Lithuanian database was performed based on the entries of the codes of chronic diseases. COPD was defined on the code J44.8 entry and six-month consumption of bronchodilators. Descriptive statistics and odds ratios (ORs) for associations and agglomerative hierarchical clustering were carried out. 321,297 patients aged 40–79 years were included; 4834 of them had COPD. A significantly higher prevalence of cardiovascular diseases (CVD), lung cancer, kidney diseases, and the association of COPD with six-fold higher odds of lung cancer (OR 6.66; p < 0.0001), a two-fold of heart failure (OR 2.61; p < 0.0001), and CVD (OR 1.83; p < 0.0001) was found. Six clusters in COPD males and five in females were pointed out, in patients without COPD—five and four clusters accordingly. The most prevalent cardiovascular cluster had no significant difference according to sex or COPD presence, but a different linkage of dyslipidemia was found. The study raises the need to elaborate adjusted multimorbidity case management and screening tools enabling better outcomes.

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“…Comorbidities not only increase the burden that people with COPD suffer but decrease quality of life [ 18 ]. COPD should be considered as the pulmonary component of multimorbidity [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Chronic Obstructive Pulmonary Disease (COPD) Comorbidities in Lithuanian National Database: A Cluster Analysis

Jurevičienė

Burneikaitė

Dambrauskas

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…1 We now know that these multimorbid diseases can have shared genetic factors with COPD. [2][3][4] Collectively, all these pulmonary and extrapulmonary conditions impact the quality of life and prognosis of the patient, and deserve diagnosis and treatment. 1 To address this, a few years ago Divo and co-workers described the 'clinical comorbidome' of COPD and identified the prevalence and relationship with mortality of many of these pulmonary and extrapulmonary conditions.…”

mentioning

confidence: 99%