When it comes to the key issues of fabrication of such materials, amorphous materials rely on harsh process conditions such as melting-quenching or polymer doping, [3] while crystalline materials mainly rely on natural crystallization in organic solvents with unmanageable crystal sizes and not good reproducibility. [1b,e,4] However, the characteristics of these reported preparation processes cause the final product to be generally in the milligram-or gramlevel, implying that the development of efficient large-scale fabrication methods will facilitate the commercial application of OLPLMs. Therefore, developing a fast, convenient, and "green" method for large-scale fabrication of OLPLMs will effectively accelerate the application development and commercialization of such materials.Generally, the rigid crystal matrix of organic crystalline materials can stabilize triplet excitons and suppress non-radiative decay, thereby improving persistent room-temperature phosphorescence (RTP) performance, that is an important strategy to enable long-persistent luminescence (LPL) performance of OLPLMs. [1c,5] Among them, host-guest doping crystals have attracted much attention, as doping of a phosphor guest into small molecular host matrices could generate the outstanding persistent-RTP effect without being easily quenched in an Purely organic long-persistent luminescence materials (OLPLMs) have shown great application potential in the fields of anti-counterfeiting and information encryption, due to their eco-friendly preparation, low synthesis cost, and easy-to-tune luminescence. Notably, the development of efficient large-scale fabrication methods will facilitate the commercial application of OLPLMs. Here, we realized the kilogram-scale preparation of organic doped-crystals with different long-persistent luminescence durations by a facile water-based method under ambient conditions. Additionally, the function of reversible multi-level temperature response of LPL performance based on this kind of OLPLMs has been achieved, showing the unique application prospects in the field of anti-counterfeiting and information encryption. This work provides an effective strategy for large-scale fabrication of OLPLMs, and will accelerate the research and development of temperature-responsive OLPLMs.