Multimodality Evoked Potentials in Motor Neuron Disease

Subramaniam, Janice Shanthi; Yiannikas, Con

doi:10.1001/archneur.1990.00530090063014

Cited by 25 publications

(15 citation statements)

References 20 publications

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“…These findings are in concordance with previous neurophysiological [12,25,30,35], and histopathological [3,9] studies of ALS. Dysfunction of the sensory system demonstrated by the present findings and by others is not the only extramotor manifestation of ALS.…”

Section: Discussionsupporting

confidence: 93%

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Evolution of motor and sensory deficits in amyotrophic lateral sclerosis estimated by neurophysiological techniques

Theys¹,

Peeters²,

Robberecht³

1999

Journal of Neurology

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Although amyotrophic lateral sclerosis is a degenerative disease of the upper and lower motor neurons, there is evidence that the disease can affect other systems, including the sensory system. On the other hand, within the motor neuron pool there is possibly a predilection of the degenerative process for the motor neurons fibers with the fastest conduction velocity (MNFCV). We studied these two aspects of the disease in a group of 50 patients by prospectively assessing several sensory indices and by studying the selectivity of the spinal motor neuron loss. At baseline, nerve conduction studies and somatosensory evoked potentials showed abnormal slowing in the peripheral and central sensory pathways. Thermal thresholds for heating were elevated but were normal for cooling. In more than 60% of the patients at least one of the sensory tests studied was abnormal. However, except for a significant decrease in the amplitude of the sensory nerve action potentials of the sural nerves, these afferent dysfunctions were not progressive over the follow-up period of 6 months, in contrast to the marked deterioration in motor functions. Three different statistical models were applied to evaluate the presence of demyelination, selective loss of MNFCV, or the purely random degeneration of fast- and slow-conducting motor neurons. These data indicate a selective loss of the MNFCV and suggest that subclinical abnormalities of the sensory system in ALS are often present but almost nonprogressive. Furthermore, the amyotrophic lateral sclerosis disease process seems preferentially to affect MNFCV.

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Section: Discussionsupporting

confidence: 93%

“…Pathological studies of familial ALS in particular have revealed abnormalities of the posterior columns [19]. Several authors have found electrophysiological involvement of the sensory systems [12, 25,30,32,35]. Whether the latter are progressive remains unclear.…”

mentioning

confidence: 99%

Evolution of motor and sensory deficits in amyotrophic lateral sclerosis estimated by neurophysiological techniques

Theys¹,

Peeters²,

Robberecht³

1999

Journal of Neurology

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“…In a previous study, evidence for a progressively reduced activation of extrastriate areas over the course of ALS was found23 and electrophysiological evidence for pathology of this area was reported 7 8. With electrophysiological techniques, the latency of the P1 component of visual evoked potentials generated by extrastriate areas24 was significantly delayed or nearly absent in ALS patients 7 8 25. These findings may be subsumed as evidence for the above mentioned demyelination of nerve fibres in the optic tract projecting to the extrastriate visual areas in ALS.…”

Section: Discussionmentioning

confidence: 85%

Neuroimaging of multimodal sensory stimulation in amyotrophic lateral sclerosis

Lulé

Diekmann

Müller

et al. 2010

Journal of Neurology, Neurosurgery & Psychiatry

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“…On the other hand, recent studies report an impairment of dorsal root ganglion cells and peripheral sensory fibres, mainly of large myelinated fibres 1A, in almost 20% of ALS patients [10,11]. Nerve conduction studies and somatosensory evoked potentials (SEPs) showed abnormal slowing in the peripheral and central sensory pathways, with an elevated thermal threshold, suggesting sub-clinical abnormalities of the sensory system in ALS [12][13][14][15][16][17][18][19][20]. Furthermore, a recent study by Hamada et al, [21] showed an abnormal amplitude increase of cortical component of SEPs in ALS.…”

Section: Introductionmentioning

confidence: 99%