Neuroimaging of multimodal sensory stimulation in amyotrophic lateral sclerosis

Lulé, Dorothée; Diekmann, V.; Müller, Hans Peter; Kassubek, Jan; Ludolph, Albert C.; Birbaumer, Niels

doi:10.1136/jnnp.2009.192260

Cited by 64 publications

(46 citation statements)

References 36 publications

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“…Related to physically hindering factors for BCI use, many users will have sensory impairments which complicate use of AAC technologies, including BCI. For example, Lulé and colleagues [41] found progressive functional deficits in secondary/higher-order visual, auditory, and somatosensory processing areas in people with ALS. Vision impairment may also concur with MS. [42] People with LIS can also suffer from visual blurring, diplopia, impaired accommodation and -with inappropriate care -corneal ulceration.…”

Section: Common Characteristics Of Typical Target Users For Bcimentioning

confidence: 97%

Design requirements and potential target users for brain-computer interfaces – recommendations from rehabilitation professionals

Nijboer

Bos

Blokland

et al. 2014

Brain-Computer Interfaces

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It is an implicit assumption in the field of brain-computer interfacing (BCI) that BCIs can be satisfactorily used to access augmentative and alternative communication (AAC) methods by people with severe physical disabilities. A one-day workshop and focus group interview was held to investigate this assumption. Rehabilitation professionals (N = 28) were asked to critically assess current BCI technology, recommend design requirements and identify target users. The individual answers were analyzed using the theoretical framework of grounded theory. None of the participants expressed a perception of added value of current BCIs over existing alternatives. A major criticism (and requirement) was that the usability of BCI systems should significantly improve. Target users are only those who can hardly or not at all use alternative access technologies. However, such persons often have concurrent physical, sensory, and cognitive problems, which could complicate BCI use. If successful BCI use continues to require a user to sit motionlessly and have intact cognition, then -as previously implicitly assumed -people in the locked-in state (resulting from late-stage amyotrophic lateral sclerosis, multiple sclerosis, spinal muscular atrophy type II or classic or total locked-in syndrome) and people with high spinal cord injury (C1/C2) could be target users.

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Section: Common Characteristics Of Typical Target Users For Bcimentioning

confidence: 97%

Design requirements and potential target users for brain-computer interfaces – recommendations from rehabilitation professionals

Nijboer

Bos

Blokland

et al. 2014

Brain-Computer Interfaces

View full text Add to dashboard Cite

show abstract

“…behavioral) function using blood oxygen level dependent imaging, has considerably increased the number of functional studies in severely restricted patients like those with ALS and has contributed to an exponential increase in scientific publications on MRI in MNDs over the last decades (see Lulé and colleagues for a review) [Lulé et al 2009]. Within the concept of multiparametric MRI, that is the combination of different MRI-based applications, there are the first observations of altered cortical activity during visual, auditory and somatosensory stimulation by fMRI in patients with ALS compared with controls, each associated with structural white matter changes assessed by DTI in corresponding brain network areas [Lulé et al 2010]. Despite the high potential of these task-based paradigms to address specific questions about motor or cognitive and other nonmotor functions, they are still biased by the limitations of physical disability.…”

Section: Computer-based Magnetic Resonance Imaging: Functional Magnetmentioning

confidence: 99%

Neuroimaging of motor neuron diseases

Kassubek¹,

Ludolph²,

Müller³

2012

Ther Adv Neurol Disord

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It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is one of the core elements in the differential diagnostic work up of patients with clinical signs of motor neuron diseases (MNDs), for example amyotrophic lateral sclerosis (ALS), to exclude MND mimics. However, the sensitivity and specificity of MRI signs in these disorders are moderate to low and do not have an evidence level higher than class IV (good clinical practice point). Currently computerized MRI analyses in ALS and other MNDs are not techniques used for individual diagnosis. However, they have improved the anatomical understanding of pathomorphological alterations in gray and white matter in various MNDs and the changes in functional networks by quantitative comparisons between patients with MND and controls at group level. For multiparametric MRI protocols, including T1-weighted three-dimensional datasets, diffusion-weighted imaging and functional MRI, the potential as a 'dry' surrogate marker is a subject of investigation in natural history studies with well defined patients. The additional value of MRI with respect to early diagnosis at an individual level and for future disease-modifying multicentre trials remains to be defined. There is still the need for more longitudinal studies in the very early stages of disease or when there is clinical uncertainty and for better standardization in the acquisition and postprocessing of computerbased MRI data. These requirements are to be addressed by establishing quality-controlled multicentre neuroimaging databases.

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“…Progressive loss of motor function may terminate in a locked-in state with loss of communication and inability to move. Over the last several years, evidence supporting the view of ALS as a multisystem disorder involving not only motor deficits has increased [1][2][3][4][5][6][7][8][9]. Cognitive impairment, especially involving frontal functions, is found in 5-50% of patients.…”

Section: Introductionmentioning

confidence: 98%

Emotional adjustment in amyotrophic lateral sclerosis (ALS)

et al. 2011

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Despite the devastating motor impairment, a significant number of patients with amyotrophic lateral sclerosis (ALS) maintain a good psychosocial adjustment. Here we investigated whether this is specific for ALS or a more general characteristic of terminal disease. Psychosocial adjustment was investigated in 30 ALS patients, 29 cancer patients in palliative treatment and 29 age-, gender- and level of education-matched healthy controls. Subjective quality of life (sQoL), degree of depressive symptoms and coping were evaluated as measures of psychosocial adjustment. Personality factors were described. ALS and cancer patients showed a good psychosocial adjustment. Subjective QoL and depression did not differ significantly. Both patient groups presented a good sQoL. The level of mild depressive symptoms in both patient groups was similar and none showed clinically relevant depression. ALS patients expressed fewer active coping strategies than cancer patients which were explained by gender differences. Both patient groups showed comparable psychosocial adjustment to their disease. Overall, in terminally ill patients the psychological response to the prognosis is not associated with neurobiological changes (e.g., associated with subclinical deficits in ALS) or with physical decline.

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Neuroimaging of multimodal sensory stimulation in amyotrophic lateral sclerosis

Cited by 64 publications

References 36 publications

Design requirements and potential target users for brain-computer interfaces – recommendations from rehabilitation professionals

Design requirements and potential target users for brain-computer interfaces – recommendations from rehabilitation professionals

Neuroimaging of motor neuron diseases

Emotional adjustment in amyotrophic lateral sclerosis (ALS)

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