Multimodal treatment of hepatocellular carcinoma

Mortality assessment of patients with hepatocellular carcinoma according to underlying disease and treatment modalities

“…Previous studies have revealed that disease-free survival, cancer recurrence rates, and mortality rates varied according to the selected treatment modality. [16,18,20,21,26,27] The advantage of liver transplantation is that it not only can treat the HCC, but also the underlying cirrhosis. However, worldwide the shortage of donor organs has greatly limited the availability of LT. [28–30] Compared to liver transplantation, surgical resection removes only HCC without dealing with the underlying liver disease, which limits its utility for HCC patients with advanced cirrhosis.…”

“…Indeed, some previous studies have suggested that transplantation provides no significant advantage for patients with early staged HCC, whereas other studies have shown that survival after surgical resection was not inferior to transplantation in the appropriate patients. [26,28,44–47] In a recent study, the outcomes of patients with early HCC (less than 2 cm, with Child Pugh A) were assessed. In this study, death within 2 years of diagnosis was 0% for both groups, whereas mortality within 3-year of diagnosis was 8.3% for transplantation and 6.7% for resection.…”

Liver transplantation for advanced hepatocellular carcinoma in patients with Child-Pugh A and B

“…In contrast, those with a comparatively preserved liver function, namely CP class A or B patients, usually receive different conventional treatments, including hepatic resection and radiofrequency ablation, with curative intent; whereas unlike the guidelines adopted at Western transplant centers, LT is considered only as a final resort when uncontrollable recurrence occurs after repeated curative treatment [3,4].…”

Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

“…Based on the clinical performance, it was characterized as "Ganji, liver obstruct, fertilizer gas, ruffian, product gas, bloating, hypochondriac pain, jaundice" and other features in traditional Chinese medicine (TCM). To date, surgical approaches including liver resection and liver transplantation are currently regarded as potentially curative treatments for HCC (Graf et al, 2014;Ravaioli et al, 2014). However, nonsurgical approaches are necessary, since only a small minority of patients is suitable for surgical therapy due to numerous lesions, extrahepatic metastases as well as early vascular liver cancer.…”