Liver transplantation for advanced hepatocellular carcinoma in patients with Child-Pugh A and B

Hammad, Ahmed; Kaido, Toshimi; Ogawa, Kohei; Fujimoto, Yasuhiro; Uemura, Tadahiro; Mori, Akira; Hatano, Etsuro; Okajima, Hideaki; Üemoto, Shinji

doi:10.1007/s00595-015-1142-2

Cited by 16 publications

(3 citation statements)

References 27 publications

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“…Although liver transplantation is a possible treatment for early-stage cases, the prohibitive costs and limited donors are prohibitive. Hepatectomy, radiofrequency ablation, and transarterial chemoembolization are more effective alternative treatment options to improve the survival rate of patients (2,3). The clinical outcome of HCC is related to various factors, including liver function, tumor size, differentiation, tumor, node, metastasis (TNM) stage, and comorbidities (4,5).…”

Section: Introductionmentioning

confidence: 99%

Preoperative computed tomography-assessed skeletal muscle index is a novel prognostic factor in patients with hepatocellular carcinoma following hepatectomy: a meta-analysis

Jing

Zhao

et al. 2020

J Gastrointest Oncol

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Background: Recently, several studies have examined the association between preoperative sarcopenia and prognosis evaluation in patients with hepatocellular carcinoma (HCC) undergoing hepatectomy. However, their conclusions remain ambiguous and controversial. Thus, we conducted a meta-analysis to assess the prognostic role of preoperative sarcopenia in patients with HCC undergoing hepatectomy. Methods: We searched the existing literature reporting on the prognostic value of preoperative computed tomography (CT)-assessed sarcopenia for the survival of patients with HCC undergoing hepatectomy. The pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of overall survival (OS) and disease-free survival (DFS) were used to assess the prognostic value of preoperative sarcopenia in HCC patients. The associations between preoperative sarcopenia and clinicopathological characteristics were also evaluated. Results: A total of six studies with 1,420 patients (including 458 sarcopenia and 962 non-sarcopenia patients) were included in the meta-analysis. The results showed that preoperative sarcopenia was significantly associated with poor OS (HR =1.572, 95% CI: 1.342-1.840, P=0) and shorter DFS (HR =1.544, 95% CI: 1.178-2.024, P=0.002) in patients with HCC undergoing hepatectomy. Preoperative sarcopenia was also significantly related to larger diameter tumors (WMD =0.598, 95% CI: 0.216-0.980, P=0.002). The results of the sensitivity analysis were stable in this meta-analysis. Egger's tests revealed that there was no significant publication bias.Conclusions: Sarcopenia appears to have significant adverse impacts on postoperative outcomes in patients with hepatocellular carcinoma following hepatectomy. However, further large-scale prospective studies are needed to confirm our findings.

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Section: Introductionmentioning

confidence: 99%

Preoperative computed tomography-assessed skeletal muscle index is a novel prognostic factor in patients with hepatocellular carcinoma following hepatectomy: a meta-analysis

Jing

Zhao

et al. 2020

J Gastrointest Oncol

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“…[ 2 ]. With the development of medical technology and improvement of health system, more and more advanced therapeutic managements have been applied to treat HCC patients, such as liver transplantation [ 3 ], proton beam therapy [ 4 ], percutaneous/laparoscopy-assisted radiofrequency ablation [ 5 ] and etc. Nevertheless, the prognosis of HCC patients remains unfavorable.…”

Section: Introductionmentioning

confidence: 99%

LncRNA TRG-AS1 stimulates hepatocellular carcinoma progression by sponging miR-4500 to modulate BACH1

et al. 2020

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Background T cell receptor gamma locus antisense RNA 1 (TRG-AS1) has been reported to involve in the progression of glioblastoma, however the role and its underlying molecular mechanism in hepatocellular carcinoma (HCC) remain unknown. Methods Quantitative real-time polymerase chain reaction (RT-qPCR) was applied to detect TRG-AS1 expression in HCC cells. Besides, the proliferation abilities of HCC cells were assessed by colony formation and EdU assays. The migratory and invasive abilities of HCC cells were examined by transwell assays. Imunofluorescence staining (IF) was used to analyze the epithelial–mesenchymal transitions (EMT). The interaction among TRG-AS1, miR-4500 and BTB domain and CNC homolog 1 (BACH1) were proofed by means of RIP and RNA pull down and luciferase reporter assays. Results TRG-AS1 was conspicuously overexpressed in HCC cells. TRG-AS1 silencing apparently suppressed HCC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT). Mechanism exploration revealed that TRG-AS1 acted as a molecular sponge of miR-4500 to regulate BACH1. MiR-4500 silencing or BACH1 overexpression in BACH1-downregulated cells fully rescued cell proliferation migration, invasion and EMT progress. Conclusion TRG-AS1 regulates HCC progression by targeting miR-4500/BACH1 axis.

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“…[ 1 ] Liver transplantation is an alternative treatment for the early stage HCC patients with chronic liver dysfunction, while hepatectomy is still the primary treatment option for HCC patients due to the limited number of available donors. [ 2 ] Improving understanding of the best surgical and perioperative management continues to decrease the perioperative morbidity and mortality of hepatectomy for HCC patients. Especially improved surgical techniques have decreased bleeding during hepatectomy and the transfusion rate has decreased from 62% to 22% over the past 2 decades; [ 3 , 4 ] Nevertheless, blood transfusion remains necessary when excessive intraoperative bleeding occurs.…”

Section: Introductionmentioning

confidence: 99%

The impact of perioperative allogeneic blood transfusion on prognosis of hepatocellular carcinoma after radical hepatectomy

Xun

Tian

et al. 2018

Medicine

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Liver transplantation for advanced hepatocellular carcinoma in patients with Child-Pugh A and B

Abstract: Living donor liver transplantation performed within the Kyoto criteria achieves excellent overall survival and recurrence rates, especially for Child-Pugh B patients, even those with advanced hepatocellular carcinoma.

Cited by 16 publications

References 27 publications

Preoperative computed tomography-assessed skeletal muscle index is a novel prognostic factor in patients with hepatocellular carcinoma following hepatectomy: a meta-analysis

Preoperative computed tomography-assessed skeletal muscle index is a novel prognostic factor in patients with hepatocellular carcinoma following hepatectomy: a meta-analysis

LncRNA TRG-AS1 stimulates hepatocellular carcinoma progression by sponging miR-4500 to modulate BACH1

The impact of perioperative allogeneic blood transfusion on prognosis of hepatocellular carcinoma after radical hepatectomy

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