Multimodal MR imaging findings of a congenital glioblastoma multiforme

Dönmez, Fuldem Yıldırım; Aslan, Hulya; Çoban, Gökçen; Özen, Özlem; Ağıldere, Muhteşem

doi:10.1007/s00381-012-1914-6

Cited by 9 publications

(13 citation statements)

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“…5,6,10,12,17,18,21,[24][25][26]28,31,[33][34][35][36]41,42 From these publications, there were 29 cases of GBM that met our inclusion criteria. The patients underwent either CT scans or MRI based on the patient's age and the clinical presentation.…”

Section: Resultsmentioning

confidence: 99%

“…33 Two publications included the results of DWI, and both tumors had restricted diffusion in the solid component. 10,34 Nineteen reports of desmoplastic tumors were identified and reviewed. From those, 9 publications were single case reports and 10 were case series with a minimum of 2 cases and a maximum of 8 cases.…”

Section: Resultsmentioning

confidence: 99%

“…Two reports included diffusion studies of their patients with infantile GBM, and in both of them diffusion was restricted. 10,34 One report provided a description of the appearance of a DIG tumor on DWI, but interpretation was limited. 37 Preoperative DWI provides valuable information about the tumor cellularity and structural integrity by measuring differences in the ADC.…”

Section: Discussionmentioning

confidence: 99%

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Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Bader¹,

Heran²,

Dunham

et al. 2015

PED

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OBJECT Two of the more common infantile brain tumors, glioblastoma multiforme (GBM) and desmoplastic infantile tumors (DITs), can be difficult to distinguish on MRI. Both tumors occur in the supratentorial compartment and both have solid and cystic components. Differentiating between the 2 on MRI studies could assist the surgeon in discussions with family and child management. The authors report on their institutional experience with both tumors, focusing on radio-graphic features, especially the diffusion studies, which might be useful in distinguishing between infantile GBM and DIT. METHODS A retrospective review was undertaken of all infantile brain tumors treated at British Columbia’s Children’s Hospital between 1982 and 2012, and cases of GBM and DIT were recorded. Only cases that had imaging were included in the study. A literature review was completed to identify reported cases of infantile GBM and DIT. Only reports that described or included radiological studies (particularly MRI) of the tumors were included. Certain radiographic features of the tumors were reviewed, including location, size, consistency, pattern of enhancement, and features on MR diffusion studies. RESULTS Of 70 cases of infantile brain tumors, 2 GBM cases and 3 DIT cases (all 3 of which were desmoplastic infantile gangliogliomas [DIGs]) met the inclusion criteria. The radiological studies obtained in all 5 cases were reviewed by a neuroradiologist. All 5 patients had supratentorial tumors with cystic-solid consistency. Diffusion MRI studies showed restricted diffusion in the 2 GBM cases, but no evidence of restricted diffusion in the DIG tumors. The GBM tumors were heterogeneously enhancing, and the DIG tumors showed avid and homogeneous enhancement. The literature review revealed 29 cases of infantile GBM and 32 cases of DIG/DIT that met the inclusion criteria. The tumors were large in both groups. The tumors were cystic-solid in consistency in 10 of 30 (33%) of GBM cases and 28 of 32 (87.5%) of DIT cases. The contrast enhancement was heterogeneous in 9 of 30 (30%) GBM cases, and it was homogeneous and avid in 27 of 32 (84%) of DIT cases. Diffusion studies were recorded in 2 published infantile GBM cases, and in both of them diffusion was restricted. The authors only found 1 report that discussed DIG tumor features on MR diffusion studies, but the interpretation was difficult and unclear. CONCLUSIONS Magnetic resonance imaging, especially diffusion-weighted imaging, may be a useful aid in distinguishing between infantile GBM and DIT tumors, with infantile GBM demonstrating restricted diffusion.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Bader¹,

Heran²,

Dunham

et al. 2015

PED

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“…Many children are stillborn or present with severe cardiovascular and respiratory problems early in the neonatal period (hypotension, bradycardia, dyspnea, cyanosis), poor reflexes, and motor deficits, resulting in low Apgar score, impending cardiovascular collapse, and possibly shock after delivery. 2,4,6,9,11,20,21,26,28 Heart failure due to blood sequestration in the highly vascular tumor or by shunting through the vascular bed has also been reported. 9 As a result, some children may die only hours after delivery, and diagnosis is established at autopsy.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

et al. 2017

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Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

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“…It is well recognized that malignant tumors restrict diffusion. This has previously been shown in pediatric 4,7 and adult GBM, diffuse intrinsic pontine gliomas, supratentorial and infratentorial primitive neuroectodermal tumors, 3,5 and metastatic malignancies.…”

mentioning

confidence: 99%

Editorial: Differentiating infantile tumors with diffusion imaging

Krieger

2015

PED

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Multimodal MR imaging findings of a congenital glioblastoma multiforme

Cited by 9 publications

References 1 publication

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

Editorial: Differentiating infantile tumors with diffusion imaging

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