Multimodal imaging of multifocal chorioretinitis secondary to endogenous candida infection

Veronese, Chiara; Maiolo, Chiara; Gurreri, Annalisa; Morara, Mariachiara; Ciardella, Antonio P.; Yannuzzi, Lawrence A.

doi:10.1007/s10792-018-1025-9

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Although it is not always possible to assess patients using imaging modalities due to their general state, more and more studies have been reporting findings of ocular candidiasis on the SD-OCT and OCTA as associated with other imaging modalities 5,6 . Stephens et al described two clear patterns of invasion based on the images acquired on the SD-OCT; the first one being the choroid and retinal infiltration of Candida spp.…”

Section: Discussionmentioning

confidence: 99%

“…Veronese et al established correlations between hypoperfusion regions on the angiography with indocyanine green dye and dark regions on the OCTA when analyzing the segment that corresponds to choriocapillaris stressing the importance of establishing comparisons between traditional imaging strategies and new imaging modalities like OCTA 6 . Thanks to these imaging modalities, we can better see progression, complications, and response to therapy.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and management of ocular candidiasis with choroidal neovascularization using multimodal imaging

Fernández¹,

Puzo²,

Barón³

et al. 2022

RMOE

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Ocular involvement due to candidemia usually occurs in patients whose health status is compromised due to immunological deficits, the presence of catheters, or recent surgeries. Therefore, it is necessary to achieve diagnosis early and do close monitoring of the disease. At present, there are many diagnostic imaging modalities available to make assessments like this. These technologies can also serve to monitor the inflammatory and infectious process, and identify the complications that may occur. This is the case of a 22-year-old woman with candida chorioretinitis in the hospital admission setting of bariatric surgery reintervention. During disease progression, the patient was treated with IV antifungals, switching to intravitreal treatment with voriconazole and aflibercept in her right eye due to the progression of the infection and the appearance of a choroidal neovascular membrane seen on the multimodal imaging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis and management of ocular candidiasis with choroidal neovascularization using multimodal imaging

Fernández¹,

Puzo²,

Barón³

et al. 2022

RMOE

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“…Aunque no siempre es posible evaluar a los pacientes con pruebas de imagen por su estado general, cada vez son más los trabajos que describen los hallazgos de la candidiasis ocular en SD-OCT y OCTA y los relacionan con otras modalidades de imagen 5,6 .…”

Section: Discussionunclassified

“…Las flechas indican el corte de la tomografía de coherencia óptica (OCT) mostrado en el apartado C. B: angiografía con fluoresceína en fase tardía que muestra zonas hipofluorescentes por efecto pantalla correspondientes con las áreas de hemorragia y zonas de tinción hiperfluorescentes en los lugares de los exudados. C: tomografía de coherencia óptica de dominio espectral en el que se observan lesiones hiperreflectivas en retina externa con discontinuidad de las líneas IS/OS (internal segment-outer segment) y del epitelio pigmentario de la retina (EPR), con sombra posterior que desdibuja la vasculatura coroidea subyacente imagen tradicionales y los nuevos medios con el OCTA 6 . Con la ayuda de estas técnicas podemos apreciar con mayor detalle el progreso, las complicaciones y la respuesta al tratamiento.…”

Section: Discussionunclassified

Diagnóstico y manejo de la candidiasis ocular con neovascularización coroidea mediante imagen multimodal

Fernández¹,

Puzo²,

Barón³

et al. 2022

Revista Mexicana De Oftalmología

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La afectación ocular secundaria a candidemia suele ocurrir frecuentemente en pacientes cuyo estado de salud se encuentra comprometido, ya sea por déficits inmunitarios, presencia de catéteres o cirugías recientes. Por ello es necesario realizar un diagnóstico temprano unido a un seguimiento estrecho de la enfermedad. Actualmente existen diversas opciones de diagnóstico por imagen que nos permiten llevar a cabo esta evaluación, permitiéndonos hacer un seguimiento del proceso inflamatorio e infeccioso, así como identificar las complicaciones que pueden surgir en este. Presentamos el caso de una paciente mujer de 22 años con coriorretinitis por cándida en el contexto de un ingreso hospitalario por reintervención de cirugía bariátrica. Durante el trascurso de la enfermedad fue tratada con antifúngicos intravenosos, pasando a tratamiento intravítreo con voriconazol y aflibercept en el ojo derecho por la progresión de la infección y la aparición de una membrana neovascular coroidea, detectada por medio de la imagen multimodal.

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“…These tools allow for a noninvasive imaging of the retina and choroid, enabling an early diagnosis and immediate treatment of numerous diseases, especially those involving the macula. Recently, it was also shown that the characteristic findings obtained via OCT facilitate a correct diagnosis in ECE cases [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: A Case Report

Kubicka-Trząska,

Bugara,

Żuber-Łaskawiec

et al. 2024

Medicina

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Background: Endogenous Candida endophthalmitis (ECE) is a rare but sight-threatening disease. Patients with ECE present with various clinical signs and symptoms, which can complicate the diagnosis. The aim of this report was to demonstrate the outcomes of treatment and to diagnose macular complications caused by intraocular inflammation. Case presentation: A 41-year-old woman with a history of acute intermittent porphyria presented with a progressive vision loss in her left eye. Left-eye OCT revealed findings consistent with a fungal etiology, which was confirmed by the culture of swabs collected from a central vein catheter. The outcomes of intravenous fluconazole treatment were not satisfactory, and the patient developed recurrent attacks of porphyria, suggesting a porphyrogenic effect of systemic antifungal therapy. Repeated intravitreal injections with amphotericin B led to a gradual regression of inflammatory lesions. However, follow-up examinations revealed active macular neovascularization (MNV) on both OCT and OCTA scans. The patient was administered intravitreal bevacizumab. At the 11th month of follow-up, OCT and OCTA scans showed significant inflammatory lesions regression with macula scarring, and no MNV activity was detected. Conclusions: This case highlights the importance of OCT and OCTA as valuable noninvasive imaging techniques for the identification of ECE, the monitoring of its clinical course, and the diagnosis of macular complications.

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Multimodal imaging of multifocal chorioretinitis secondary to endogenous candida infection

Cited by 5 publications

References 5 publications

Diagnosis and management of ocular candidiasis with choroidal neovascularization using multimodal imaging

Diagnosis and management of ocular candidiasis with choroidal neovascularization using multimodal imaging

Diagnóstico y manejo de la candidiasis ocular con neovascularización coroidea mediante imagen multimodal

Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: A Case Report

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