Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery (Adv. Funct. Mater. 21/2022)

Lin, Long; Wang, Yuqiong; Cai, Minkun; Jiang, Xinran; Hu, Yongyan; Dong, Zaizai; Yin, Dedong; Liu, Yilin; Yang, Shaohua; Liu, Zhiguang; Zhuang, Jian; Xu, Yun; Guo, Chuan; Chang, Lingqian

doi:10.1002/adfm.202270122

Cited by 11 publications

(9 citation statements)

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“…For better adaptation to the purpose of drug delivery within the gastric wall, sufficient mechanical strength of the LGP‐MN is necessary to ensure its effective penetration into the gastric wall and drug delivery to a specific depth. [ 36 ] Compression test shows an ~35 µm needle‐tip displacement under a 0.56 N compressive force corresponding to the 3.183 MPa skin‐penetration pressure, which is an unobservable deformation in all three types of LGP‐MNs [ 37 ] (Figure 2B; Figures S3 and S4A, Supporting Information). The flexibility of the LGP‐MN was tested, and the results showed a maximum flexure of >30% (≈30°), satisfying the surface flexure of the stomach (Figure 2C and Figure S4B, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Layer‐Specific BTX‐A Delivery to the Gastric Muscularis Achieves Effective Weight Control and Metabolic Improvement

Wang

Lin

et al. 2023

Advanced Science

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The rising incidence of health‐endangering obesity constantly calls for more effective treatments. Gastric intramural injection of botulinum neurotoxin A (BTX‐A) as a new modality carries great promise yet inconsistent therapeutic efficacy. A layer‐specific delivery strategy enabled by dissolving microneedles is hence pioneered to investigate the working site of BTX‐A and the resulting therapeutic effects. The drug‐loaded tips of the layer‐specific gastric paralysis microneedles (LGP‐MN) rapidly release and achieve uniform distribution of BTX‐A within the designated gastric wall layers. In an obesity rat model, the LGP‐MNs not only prove safer than conventional injection, but also demonstrate consistently better therapeutic effects with muscular layer delivery, including 16.23% weight loss (3.06‐fold enhancement from conventional injection), 55.20% slower gastric emptying rate, improved liver steatosis, lowered blood lipids, and healthier gut microbiota. Further hormonal study reveals that the elevated production of stomach‐derived glucagon‐like peptide‐1 due to the muscularis‐targeting LGP‐MN treatment is an important contributor to its unique glucose tolerance‐improving effect. This study provides clear indication of the gastric muscularis as the most favorable working site of BTX‐A for weight loss and metabolic improvement purposes, and meanwhile suggests that the LGP‐MNs could serve as a novel clinical approach to treat obesity and metabolic syndromes.

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Section: Resultsmentioning

confidence: 99%

Layer‐Specific BTX‐A Delivery to the Gastric Muscularis Achieves Effective Weight Control and Metabolic Improvement

Wang

Lin

et al. 2023

Advanced Science

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“…[ 1–4 ] Historically, microinjection protocols have relied on using a single hollow microneedle to deliver target substances (e.g., cells, DNA, RNA, micro/nanoparticles) to a singular location of interest. [ 5–7 ] Recently, however, alternatives in the form of microneedle arrays (MNAs) have garnered increasing interest due to a wide range of benefits over their single‐needle counterparts, including the ability to rapidly deliver target material over a large, distributed area, which has proven to be particularly beneficial for transdermal and intradermal drug delivery. [ 8–11 ] Despite the significant potential of MNAs for microinjection applications, the majority of current MNA developments are founded on solid (e.g., coated and/or dissolvable) microneedles that are inherently incompatible with active fluidic microinjection protocols.…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Microinjection Needle Arrays via a Hybrid DLP‐Direct Laser Writing Strategy

Sarker

Colton

Wen

et al. 2023

Adv Materials Technologies

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Microinjection protocols are ubiquitous throughout biomedical fields, with hollow microneedle arrays (MNAs) offering distinctive benefits in both research and clinical settings. Unfortunately, manufacturing‐associated barriers remain a critical impediment to emerging applications that demand high‐density arrays of hollow, high‐aspect‐ratio microneedles. To address such challenges, here, a hybrid additive manufacturing approach that combines digital light processing (DLP) 3D printing with “ex situ direct laser writing (esDLW)” is presented to enable new classes of MNAs for fluidic microinjections. Experimental results for esDLW‐based 3D printing of arrays of high‐aspect‐ratio microneedles—with 30 µm inner diameters, 50 µm outer diameters, and 550 µm heights, and arrayed with 100 µm needle‐to‐needle spacing—directly onto DLP‐printed capillaries reveal uncompromised fluidic integrity at the MNA‐capillary interface during microfluidic cyclic burst‐pressure testing for input pressures in excess of 250 kPa (n = 100 cycles). Ex vivo experiments perform using excised mouse brains reveal that the MNAs not only physically withstand penetration into and retraction from brain tissue but also yield effective and distributed microinjection of surrogate fluids and nanoparticle suspensions directly into the brains. In combination, the results suggest that the presented strategy for fabricating high‐aspect‐ratio, high‐density, hollow MNAs could hold unique promise for biomedical microinjection applications.

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“…Recently, the rapid development of intrinsically stretchable organic semiconductor materials, especially organic polymers, has encouraged the potential of OTFTs as skin-like sensors. [5][6][7][8] However, conventional OTFTs must overcome their low-temperature sensitivity and electrical instability under strain to be adopted as skin-like temperature sensors. [9][10][11] In addition, their high operating voltage should be lowered to reduce power consumption, given the limited capacity of rechargeable batteries.…”

Section: Introductionmentioning

confidence: 99%

Intrinsically Stretchable Subthreshold Organic Transistors for Highly Sensitive Low‐Power Skin‐Like Active‐Matrix Temperature Sensors

Kim,

Jeong,

Nam

et al. 2023

Adv Funct Materials

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Stretchable wearable sensors ultimately require low power consumption and high response to physiological signals with skin conformability. However, power‐response tradeoff and strain‐dependent sensing instability remain key challenges for electronic skin (e‐skin) sensors. Herein,an intrinsically stretchable organic subthreshold transistor operating at low voltage (−1 V) is presented, leading to ultralow power consumption (<1 nW) for highly sensitive skin‐like temperature sensory devices. The highly temperature‐dependent hopping transport of the fully stretchable subthreshold transistor exhibits high‐temperature sensitivity (9.4% °C−1) and excellent sensing stability up to 100% strain. A skin‐like subthreshold organic transistor active‐matrix array is successfully fabricated that sensed the surface temperature distribution under a 3D deformation.

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Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery (Adv. Funct. Mater. 21/2022)

Cited by 11 publications

References 0 publications

Layer‐Specific BTX‐A Delivery to the Gastric Muscularis Achieves Effective Weight Control and Metabolic Improvement

Layer‐Specific BTX‐A Delivery to the Gastric Muscularis Achieves Effective Weight Control and Metabolic Improvement

3D‐Printed Microinjection Needle Arrays via a Hybrid DLP‐Direct Laser Writing Strategy

Intrinsically Stretchable Subthreshold Organic Transistors for Highly Sensitive Low‐Power Skin‐Like Active‐Matrix Temperature Sensors

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