Multimaterial and multifunctional neural interfaces: from surface-type and implantable electrodes to fiber-based devices

Sung, Changhoon; Jeon, Woojin; Nam, Kum Seok; Kim, Yeji; Butt, Haider; Park, Seongjun

doi:10.1039/d0tb00872a

Cited by 54 publications

(56 citation statements)

References 390 publications

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“…The use of optogenetic manipulation will make it possible to control neural activity with cell-type and projection selectivity, which will advance our understanding of specific circuit activity and behaviors (Miyamoto and Murayama, 2016). Chemically, neurotransmitter measurements and stimulation can be another useful add-on function in neural interfaces (Sung et al, 2020). Neurotransmitters play an important role in neural communications (Niyonambaza et al, 2019).…”

Section: Remaining Challenges and Future Directionmentioning

confidence: 99%

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

et al. 2021

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Neural interfacing devices using penetrating microelectrode arrays have emerged as an important tool in both neuroscience research and medical applications. These implantable microelectrode arrays enable communication between man-made devices and the nervous system by detecting and/or evoking neuronal activities. Recent years have seen rapid development of electrodes fabricated using flexible, ultrathin carbon-based microfibers. Compared to electrodes fabricated using rigid materials and larger cross-sections, these microfiber electrodes have been shown to reduce foreign body responses after implantation, with improved signal-to-noise ratio for neural recording and enhanced resolution for neural stimulation. Here, we review recent progress of carbon-based microfiber electrodes in terms of material composition and fabrication technology. The remaining challenges and future directions for development of these arrays will also be discussed. Overall, these microfiber electrodes are expected to improve the longevity and reliability of neural interfacing devices.

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Section: Remaining Challenges and Future Directionmentioning

confidence: 99%

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

et al. 2021

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“…It has been certainly demonstrated by the articles cited within this review that modern bioelectronics suffer from a physical interface problem. Addressing this problem, making the perfect neural connector to plug into, can partially be addressed by improvements in microfabrication (HajjHassan et al, 2008;Sung et al, 2020;Zhu et al, 2014). The ideal electrode interface would be able to very selectively record from and/or stimulate unique neurons within a large pool of cells, which means that individual electrode leads should be less than a few micrometers thick.…”

Section: Physical Interface Problemmentioning

confidence: 99%

Cut wires: The Electrophysiology of Regenerated Tissue

Lowe

Thakor

2021

Bioelectron Med

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When nerves are damaged by trauma or disease, they are still capable of firing off electrical command signals that originate from the brain. Furthermore, those damaged nerves have an innate ability to partially regenerate, so they can heal from trauma and even reinnervate new muscle targets. For an amputee who has his/her damaged nerves surgically reconstructed, the electrical signals that are generated by the reinnervated muscle tissue can be sensed and interpreted with bioelectronics to control assistive devices or robotic prostheses. No two amputees will have identical physiologies because there are many surgical options for reconstructing residual limbs, which may in turn impact how well someone can interface with a robotic prosthesis later on. In this review, we aim to investigate what the literature has to say about different pathways for peripheral nerve regeneration and how each pathway can impact the neuromuscular tissue’s final electrophysiology. This information is important because it can guide us in planning the development of future bioelectronic devices, such as prosthetic limbs or neurostimulators. Future devices will primarily have to interface with tissue that has undergone some natural regeneration process, and so we have explored and reported here what is known about the bioelectrical features of neuromuscular tissue regeneration.

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“…The primary reason stems from the soft and complex nature of the neural tissues, as the mechanical mismatch between the biotic and rigid synthetic interfaces easily induces foreign body responses. Such biological responses are often responsible for the degradation of device performances, and the damage caused can even trigger neurodegeneration ( Sung et al., 2020 ). Intimate interfacing with the target is another task that has to be solved to reach for high-fidelity signal acquisition and delivery ( Li et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in recording and modulation technologies for next-generation neural interfaces

Hong¹,

Yoon²,

Jo³

et al. 2021

iScience

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Summary Along with the advancement in neural engineering techniques, unprecedented progress in the development of neural interfaces has been made over the past few decades. However, despite these achievements, there is still room for further improvements especially toward the possibility of monitoring and modulating neural activities with high resolution and specificity in our daily lives. In an effort of taking a step toward the next-generation neural interfaces, we want to highlight the recent progress in neural technologies. We will cover a wide scope of such developments ranging from novel platforms for highly specific recording and modulation to system integration for practical applications of novel interfaces.

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Multimaterial and multifunctional neural interfaces: from surface-type and implantable electrodes to fiber-based devices

Abstract: Development of neural interfaces from surface electrodes to fibers with various type, functionality, and materials.

Cited by 54 publications

References 390 publications

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

Cut wires: The Electrophysiology of Regenerated Tissue

Recent advances in recording and modulation technologies for next-generation neural interfaces

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