Multilayer, degradable coating as a carrier for the sustained release of antibiotics: Preparation and antimicrobial efficacy in vitro

Guillaume, Olivier; Garric, Xavier; Lavigne, Jean‐Philippe; Berghe, Hélène Van Den; Coudane, Jean

doi:10.1016/j.jconrel.2012.08.003

Cited by 90 publications

(81 citation statements)

References 49 publications

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“…[116][117][118] An important aspect of these nanoparticles is the requirement of toxicity-free synthesis. These nanomaterials present interesting morphologies, including spheres, tubes, rods, and prisms.…”

Section: Metal Nanomaterialsmentioning

confidence: 99%

Prevention and treatment of biofilms by hybrid- and nanotechnologies

Kasimanickam¹,

Ranjan²,

Asokan³

et al. 2013

IJN

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Bacteria growing as adherent biofilms are difficult to treat and frequently develop resistance to antimicrobial agents. To counter biofilms, various approaches, including prevention of bacterial surface adherence, application of device applicators, and assimilation of antimicrobials in targeted drug delivery machinery, have been utilized. These methods are also combined to achieve synergistic bacterial killing. This review discusses various multimodal technologies, presents general concepts, and describes therapies relying on the principles of electrical energy, ultrasound, photodynamics, and targeted drug delivery for prevention and treatment of biofilms.

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Section: Metal Nanomaterialsmentioning

confidence: 99%

Prevention and treatment of biofilms by hybrid- and nanotechnologies

Kasimanickam¹,

Ranjan²,

Asokan³

et al. 2013

IJN

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“…The lamellar liquid structure is considered suitable for drug delivery because the sustained drug release was reported to be possible with the multilayer structured carrier. 44,45 There was no difference in the SAXD and WAXD patterns with increasing concentrations of BMK-20113. Therefore, it can be concluded that the lateral packing of lipids at the surface of the LCNPs was not concentration-dependent.…”

Section: Discussionmentioning

confidence: 91%

“…The improvement in the bioavailability of the BMK-20113 incorporated in the LCNPs is presumably attributable to the multilayer structure of LCNPs, which offers sustained drug release. 44 In addition, the liquid crystal structure protects the drug within the gastrointestinal tract, thereby enhancing its stability because the drug is encapsulated in the lipid core. Moreover, the outer layer is PEGylated with ceteareth-12 and ceteareth-20, which function as a stealth layer under gastrointestinal conditions; therefore, the BMK-20113 incorporated into the LCNPs is more stable than with the HGC.…”

Section: Discussionmentioning

confidence: 99%

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Lee¹,

Park²,

Bae³

et al. 2016

IJN

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Liquid crystal nanoparticles have been utilized as an efficient tool for drug delivery with enhanced bioavailability, drug stability, and targeted drug delivery. However, the high energy requirements and the high cost of the liquid crystal preparation have been obstacles to their widespread use in the pharmaceutical industry. In this study, we prepared liquid crystal nanoparticles using a phase-inversion temperature method, which is a uniquely low energy process. Particles prepared with the above method were estimated to be ~100 nm in size and exhibited a lamellar liquid crystal structure with orthorhombic lateral packing. Pharmacokinetic and tissue distribution studies of a hydrophobic peptide-based drug candidate formulated with the liquid crystal nanoparticles showed a five-fold enhancement of bioavailability, sustained release, and liver-specific drug delivery compared to a host–guest complex formulation.

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“…In addition, the numbers of CFU in the biofilms were measured according to the protocol described in the literature (41). Briefly, after plain and monolaurin-coated wires were exposed to the bacterial inocula for 48 h to create a biofilm, each wire was gently rinsed three times with sterile PBS and placed in a test tube with 1 ml of sterile PBS.…”

Section: Methodsmentioning

confidence: 99%

Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections

Gil

Shuvaev

Frank-Kamenetskii

et al. 2017

Antimicrob Agents Chemother

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Novel approaches to the prevention of microbial infections after the insertion of orthopedic external fixators are in great demand because of the extremely high incidence rates of such infections, which can reach up to 100% with longer implant residence times. Monolaurin is an antimicrobial agent with a known safety record that is broadly used in the food and cosmetic industries; however, its use in antimicrobial coatings of medical devices has not been studied in much detail. Here, we report the use of monolaurin as an antibacterial coating on external fixators for the first time. Monolaurin-coated Kirschner wires (K-wires) showed excellent antibacterial properties against three different bacterial strains, i.e., methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and Staphylococcus epidermidis. Approximately 6.0-log reductions of both planktonic and adherent bacteria were achieved using monolaurin-coated K-wires, but monolaurin-coated K-wires did not show any observable cytotoxicity with mouse osteoblast cell cultures. Overall, monolaurin-coated K-wires could be promising as potent antimicrobial materials for orthopedic surgery.

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Multilayer, degradable coating as a carrier for the sustained release of antibiotics: Preparation and antimicrobial efficacy in vitro

Cited by 90 publications

References 49 publications

Prevention and treatment of biofilms by hybrid- and nanotechnologies

Prevention and treatment of biofilms by hybrid- and nanotechnologies

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections

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