Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice

Rahman, Saidur; Pang, Won-Ki; Ryu, Do-Yeal; Park, Yoo-Jin; Ryu, Buom‐Yong; Pang, Myung-Geol

doi:10.1016/j.jhazmat.2021.125791

Cited by 40 publications

(12 citation statements)

References 59 publications

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“…While TiO 2 NPs and bisphenol A (BPA) interact reciprocally in their toxic effects on the male reproductive system and offspring, NMs can increase the bioaccumulation of BPA (Chen, Hu, et al, 2018;Chen, Yin, et al, 2017). Thus, NMs can act as carriers of BPA to enhance its concentration in vivo, leading to endocrine disruption and impairment of reproduction (Fang et al, 2016;Rahman, 2021;Sweeney, 2015). Di-n-butyl phthalate (DBP) is extensively used as a plasticizer and often released into the environment.…”

Section: Combined Toxicity Of Nms and Endocrine Disruptorsmentioning

confidence: 99%

The potential for nanomaterial toxicity affecting the male reproductive system

Ning

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

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With the development of nanotechnology, nanomaterials offer great advantages in a wide variety of industrial and consumer products, and show promise for biomedical applications. However, with these new products, nanomaterial pollutants may enter the human body to cause adverse health effects, including hazards to the male reproductive system. Nanomaterials can enter the body through inhalation, oral exposure, or intravenous injection, and reach the testis via the blood, penetrate the Sertoli cell barrier, and directly or indirectly elicit toxicopathological changes to the testicles. These may then trigger hormone disorders, inhibit spermatogenic cell proliferation, and induce apoptosis, ultimately leading to a decrease in sperm motility and number, ultimately diminishing male reproductive capacity. This review will discuss the toxicological effects of nanomaterials on the male reproductive system, including inflammation, the impact on the hypothalamic–pituitary–gonadal axis (HPG axis), lipid peroxidation, and free ion release relevant to germ cells, Sertoli cell tight junctions, and the gonadal endocrine system.This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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Section: Combined Toxicity Of Nms and Endocrine Disruptorsmentioning

confidence: 99%

The potential for nanomaterial toxicity affecting the male reproductive system

Ning

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…daily. The BPA dose was selected according to the study by Rahman et al (2021b) who said that environmental exposure to BPA during pregnancy affects the fertility in future generations in both humans and the other animals. Group C received daily dose of BPA at 50 mg/kg b.w.…”

Section: Experimental Approachmentioning

confidence: 99%

Retrieval action of zinc and folic acid for the restoration of normal reproductive function in bisphenol-A exposed male albino mice

Mustari¹,

Alam²,

Moody³

et al. 2022

Vet. Med. - Czech

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Bisphenol-A (BPA) has become a great concern due to its toxic effects. The present study investigated the retrieval action of zinc (Zn) and folic acid (FA) supplementation against BPA-induced reproductive toxicities in male albino mice. A total of seventy-five 25–28 day-old mice were divided into five equal groups (group A–E, 15 mice in each group). The mice were given normal rations (control, group A) or administered with daily doses of BPA at 50 mg/kg body weight (b.w.) (group B–E). The mice from groups C, D and E were supplemented with Zn (10 mg/kg b.w.), FA (3 mg/kg b.w.) and both in the feed, respectively, daily for 12 weeks. Blood samples were collected, and the sera were separated for biochemical and hormonal analyses. The standard method was followed to test the sperm motility and sperm count. The testis samples were processed for a routine histopathological study using haematoxylin and eosin staining. The sperm counts, motility, and serum testosterone significantly declined in the BPA-exposed animals, but dramatically increased after the Zn and FA supplementation. There was significant degeneration of the seminiferous tubules in the testes of the BPA-exposed mice, which was recovered moderately by the Zn and FA supplementation. The study shows the retrieval action of zinc and folic acid in the restoration of normal reproductive function in bisphenol-A exposed male mice.

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“…The variation of four selected representative proteins was validated in Western blotting [ 43 ]. Recently, Rahman and co-authors extended their study to the second (F2) and third (F3) generations of male mice generated by females exposed to LOAEL doses of BPA during their pregnancy [ 142 ]. They specifically focused on the six deregulated proteins identified in their 2017 study [ 42 ].…”

Section: Impact Of Infertility Risk Factors On Sperm Proteinsmentioning

confidence: 99%

“…Except for superoxide dismutase (SOD), which was deregulated in spermatozoa from F1 males only, the five other proteins—GPX4, ATP synthase subunit O (ATP5O), glutathione S-transferase (GSTM5), NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 (NDUFA10), and Isoaspartyl peptidase/L-asparaginase (ASRGL1)—were also deregulated in spermatozoa from F2 males. All the proteins returned to the control level in F3 males [ 142 ]. In addition, Rahman et al [ 143 ] showed that the spermatozoa from male mice (F0) exposed to NOAEL and LOAEL doses of BPA presented increased levels of lactate dehydrogenase (LDH), while control levels of this enzyme were measured for males (F1–F3) generated after breeding with non-exposed females ( Table S1 ).…”

Section: Impact Of Infertility Risk Factors On Sperm Proteinsmentioning

confidence: 99%

Influence of Risk Factors for Male Infertility on Sperm Protein Composition

Bisconti

Simon

Grassi

et al. 2021

IJMS

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Male infertility is a common health problem that can be influenced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These effects have been largely demonstrated on sperm parameters (e.g., motility, numeration, vitality, DNA integrity). In addition, several studies showed the deregulation of sperm proteins in relation to some of these factors. This review inventories the literature related to the identification of sperm proteins showing abundance variations in response to the four risk factors for male infertility that are the most investigated in this context: obesity, diabetes, tobacco smoking, and exposure to bisphenol-A (BPA). First, we provide an overview of the techniques used to identify deregulated proteins. Then, we summarise the main results obtained in the different studies and provide a compiled list of deregulated proteins in relation to each risk factor. Gene ontology analysis of these deregulated proteins shows that oxidative stress and immune and inflammatory responses are common mechanisms involved in sperm alterations encountered in relation to the risk factors.

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Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice

Cited by 40 publications

References 59 publications

The potential for nanomaterial toxicity affecting the male reproductive system

The potential for nanomaterial toxicity affecting the male reproductive system

Retrieval action of zinc and folic acid for the restoration of normal reproductive function in bisphenol-A exposed male albino mice

Influence of Risk Factors for Male Infertility on Sperm Protein Composition

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