Multifunctional thermosensitive hydrogel based on alginate and P(NIPAM-co-HEMIN) composites for accelerated diabetic wound healing

Wang, Yuyang; Addisu, Kefyalew Dagnew; Gebrie, Hailemichael Tegenu; Darge, Haile Fentahun; Wu, Tsung-Yun; Hong, Zhenxiang; Tsai, Hsieh‐Chih

doi:10.1016/j.ijbiomac.2023.124540

Cited by 6 publications

(7 citation statements)

References 56 publications

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“…Wang et al utilized alginate-based hydrogels containing hemin (protoporphyrin IX with a ferric iron ion) and AgNPs to enhance antibacterial activity and ROS scavenging, while also promoting cell attachment and growth. 100 Similarly, AgNPs were synthesized from aloe leaf extracts using biosynthetic techniques. These green MNPs showed satisfactory inhibition of Staphylococcus aureus.…”

Section: Research and Application Of Mnps In Wound Healingmentioning

confidence: 99%

“…The aforementioned p(NIPAM-co-hemin)/ALG-EDA hydrogel, 100 AgNP@CNDM hydrogel, 97 the SF/GA/Zn hybrid hydrogel 89 and chitosan/Ca-AlgNP/AgNP hydrogel 98 demonstrate the capability of sustained release, which ensures a suitable concentration of metal ions for bactericidal activity in wounds. Simultaneously, these hydrogels exhibit an enhanced mechanical strength and adhesion rate, enabling optimal wound coverage and continuous moisturization to promote wound healing.…”

Section: Application Of Metal-based Nanoparticles To Biomaterialsmentioning

confidence: 99%

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Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

Zheng,

Chen,

Liu

et al. 2024

IJN

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Diabetic wounds pose a significant challenge to public health, primarily due to insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places a significant physical burden on patients’ prognosis, but also amplifies the economic strain on the medical system in treating diabetic wounds. Currently, the effectiveness of available treatments for diabetic wounds is limited. However, there is hope in the potential of metal nanoparticles (MNPs) to address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial and pro-angiogenic properties, making them a promising solution for diabetic wounds. In addition, MNPs stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials such as hydrogels and chitosan, novel dressings can be developed and revolutionize the treatment of diabetic wounds. The present article provides a comprehensive overview of the research progress on the utilization of MNPs for treating diabetic wounds. Building upon this foundation, we summarize the underlying mechanisms involved in diabetic wound healing and discuss the potential application of MNPs as biomaterials for drug delivery. Furthermore, we provide an extensive analysis and discussion on the clinical implementation of dressings, while also highlighting future prospects for utilizing MNPs in diabetic wound management. In conclusion, MNPs represent a promising strategy for the treatment of diabetic wound healing. Future directions include combining other biological nanomaterials to synthesize new biological dressings or utilizing the other physicochemical properties of MNPs to promote wound healing. Synthetic biomaterials that contain MNPs not only play a role in all stages of diabetic wound healing, but also provide a stable physiological environment for the wound-healing process.

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Section: Research and Application Of Mnps In Wound Healingmentioning

confidence: 99%

Section: Application Of Metal-based Nanoparticles To Biomaterialsmentioning

confidence: 99%

Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

Zheng,

Chen,

Liu

et al. 2024

IJN

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“…ATRP was chosen based on the ability to synthesize hydrophilic polymers with a stable structure and controllable relative molecular mass, 46 and the copper-free polymerization would reduce the potential biotoxicity of cupric ion residue in cell binding. The copolymers synthesized by NIPAm and AGE exhibited good temperature responsiveness and excellent hydrophilicity, 51 in which the epoxy groups can be utilized to introduce other ligands. To demonstrate the binding ability of the BSA-derived composite to bacteria as affinity material, S. aureus (Grampositive bacteria) and Salmonella spp.…”

Section: Evaluation Andmentioning

confidence: 99%

In Situ Preparation of Star-Shaped Protein–“Smart” Polymer Conjugates with pH and Thermo-Dual Responsibility for Bacterial Separation

Wei,

Zheng,

Gao

et al. 2024

J. Agric. Food Chem.

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To achieve effective separation and enrichment of bacteria, a novel synthetic scheme was developed to synthesize star-style boronate-functionalized copolymers with excellent hydrophilicity and temperature and pH responsiveness. A hydrophilic copolymer brush was synthesized by combining surface-initiated atom-transfer radical polymerization with amide reaction using bovine serum albumin as the core. The copolymer brush was further modified by introducing and immobilizing fluorophenylboronic acids through an amide reaction, resulting in the formation of boronate affinity material BSA@poly(NIPAm-co-AGE)@DFFPBA. The morphology and organic content of BSA@poly(NIPAm-co-AGE)@DFFPBA were systematically characterized. The BSA-derived composites demonstrated a strong binding capacity to both Gram-positive and Gram-negative bacteria. The binding capabilities of the affinity composite to Staphylococcus aureus and Salmonella spp. were 195.8 × 1010 CFU/g and 79.2 × 1010 CFU/g, respectively, which indicates that the novel composite exhibits a high binding capability to bacteria and shows a particularly more significant binding capacity toward Gram-positive bacteria. The bacterial binding of BSA@poly(NIPAm-co-AGE)@DFFPBA can be effectively altered by adjusting the pH and temperature. This study demonstrated that the star-shaped affinity composite had the potential to serve as an affinity material for the rapid separation and enrichment of bacteria in complex samples.

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“…SA contains a large number of carboxyl (−COOH) and hydroxyl (−OH) groups, which allow it to effectively absorb the exudate secreted from wounds during chronic wound healing by the large number of hydrophilic groups. 32 In addition, SA is introduced to form a dual physically and chemically triple crosslinked network by the free −COOH, −OH of CS/Cur-SA (CSA), and −OH of poly(vinyl alcohol) (PVA). The hydrogels with appropriate mechanical properties may provide new opportunities for wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…To improve the long-lasting antimicrobial and pro-angiogenic properties of CS/Cur and achieve stability and slow and sustainable release, the long-term stability of CS/Cur is adjusted by introducing sodium alginate (SA). SA contains a large number of carboxyl (−COOH) and hydroxyl (−OH) groups, which allow it to effectively absorb the exudate secreted from wounds during chronic wound healing by the large number of hydrophilic groups . In addition, SA is introduced to form a dual physically and chemically triple crosslinked network by the free −COOH, −OH of CS/Cur-SA (CSA), and −OH of poly(vinyl alcohol) (PVA).…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

Fan,

Huang,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the wound area. Therefore, it is of great importance to develop a novel multifunctional hydrogel with high efficiency to accelerate diabetic wound healing. Curcumin (Cur), a Chinese herbal, has shown great potential in enhancing the healing of diabetic chronic wounds because of its immunomodulatory and pro-angiogenic properties. However, its low aqueous solubility, poor bioavailability, and chemical instability have limited its clinical applications. To address these current bottlenecks, novel poly(vinyl alcohol) (PVA)− chitosan (CS)/sodium alginate (SA)−Cur (PCSA) hydrogels were prepared for the first time, and they demonstrated all of the above intriguing performances by the Michael addition reaction of CS and Cur. PCSA hydrogels show multiple dynamic bonds, which possess strong mechanical properties (tensile stress: ∼0.980 MPa; toughness: ∼258.45 kJ/m 3 ; and compressive strength: ∼7.38 MPa at strain of 80%). These intriguing performances provided an optimal microenvironment for cell migration and proliferation and also promoted the growth of blood vessels, leading to early angiogenesis. Importantly, the experimental results demonstrated that PCSA hydrogels can effectively transform pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages without the need for additional ingredients in vitro. Benefiting from these characteristics, a full-thickness diabetic wound in a rat model demonstrated that PCSA hydrogels can effectively accelerate wound healing via ROS-scavenging, downregulation of IL-1β, and upregulation of CD31 expression, resulting in angiogenesis and collagen deposition. This strategy not only provides a simple and safe Cur-based hydrogel for diabetic wound healing but also highlights the significant potential for the development of high-performance biomaterials for promoting diabetic wound healing using traditional Chinese medicine.

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Multifunctional thermosensitive hydrogel based on alginate and P(NIPAM-co-HEMIN) composites for accelerated diabetic wound healing

Cited by 6 publications

References 56 publications

Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

In Situ Preparation of Star-Shaped Protein–“Smart” Polymer Conjugates with pH and Thermo-Dual Responsibility for Bacterial Separation

A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

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