Multifunctional Theranostic Graphene Oxide Nanoflakes as MR Imaging Agents with Enhanced Photothermal and Radiosensitizing Properties

Beik, Jaber; Alamzadeh, Zahra; Mirrahimi, Mehri; Sarikhani, Abolfazl; Ardakani, Tahereh Shakerian; Asadi, Mohamadreza; Irajirad, Rasoul; Mirrahimi, Mehraban; Mahabadi, Vahid Pirhajati; Eslahi, Neda; Bulte, Jeff W.M.; Ghaznavi, Habib; Shakeri‐Zadeh, Ali

doi:10.1021/acsabm.1c00104

Cited by 17 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, magnetic nanoparticles are combined with an NIR dye or other nanoparticles that can exhibit high photothermal effects. Thus, near-infrared laser irradiation can be used for therapeutic applications, and magnetic resonance imaging-guided photothermal therapy can be used for tumor ablation. − …”

Section: Size-dependent Materials Properties At the Nanoscale With Bi...mentioning

confidence: 99%

Nanoparticle Size Effects in Biomedical Applications

Dolai

Mandal

Jana

2021

ACS Appl. Nano Mater.

118

View full text Add to dashboard Cite

Nanoparticle size plays a central role in determining material properties and performance in biomedical applications. A wide variety of functional nanomaterials and nano-bioconjugates have been developed for monitoring biochemical activity, controlling biological functions, and therapeutic applications. This review focuses on the role of nanoparticle size (typically in the range of 1−100 nm) in various biomedical applications, the origin of such a size effect, and the optimum size requirement for the best performance in different biomedical applications. First, we discuss various nanoscale units present in life processes along with their size and functional role. Next, we discuss the size-dependent properties of some well-known nanoparticles and how those properties are exploited in different biomedical applications. Next, we discuss the size-dependent performance of functional nanomaterials and nano-bioconjugates that are used in various biomedical applications. Then, we highlight some of the best designed nanoparticles of optimum size for specific biomedical applications. Finally, we attempt to correlate the origin of the evolutionary selection of various nanoscale units in life processes toward specific biological functions.

show abstract

Section: Size-dependent Materials Properties At the Nanoscale With Bi...mentioning

confidence: 99%

Nanoparticle Size Effects in Biomedical Applications

Dolai

Mandal

Jana

2021

ACS Appl. Nano Mater.

118

View full text Add to dashboard Cite

show abstract

“…It has been shown [30] that multifunctional theranostic nanostructures, consisting of superparamagnetic iron oxide and gold nanoparticles scuffed inside graphene oxide nanoflasts, can be used for double photo/radiation therapy due to near-infrared absorption of graphene oxide for photothermal therapy and radiosensitization by gold nanoparticles for enhanced radiation therapy. At the same time, this nanoplatform can also be detected by MRI imaging, due to the presence of iron compound nanoparticles.…”

Section: Modern Platforms For Theranostics Applied For Treating Various Pathologiesmentioning

confidence: 99%

The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

et al. 2021

View full text Add to dashboard Cite

This review presents the main patterns of synthesis for theranostics platforms. We examine various approaches to the interpretation of theranostics, statistics of publications drawn from the PubMed database, and the solid-state and medicinal chemistry methods used for the formation of nanotheranostic objects. We highlight and analyze chemical methods for the modification of nanoparticles, synthesis of spacers with functional end-groups, and the immobilization of medicinal substances and fluorophores. An overview of the modern solutions applied in various fields of medicine is provided, along with an outline of specific examples and an analysis of modern trends and development areas of theranostics as a part of personalized medicine.

show abstract

“…29 Emerging nanomaterials have shown unique advantages in biomedical applications, and have been widely used in enhancing radiosensitization. [30][31][32][33] In particular, gold-based nanomaterials have been the most widely studied. On the one hand, goldbased nanomaterials have good biocompatibility, easy surface modification and controllable size, as well as unique chemical and optical properties.…”

Section: Introductionmentioning

confidence: 99%