Nanoparticle Size Effects in Biomedical Applications

Dolai, Jayanta; Mandal, Kuheli; Jana, Nikhil R.

doi:10.1021/acsanm.1c00987

Cited by 117 publications

(102 citation statements)

References 180 publications

(557 reference statements)

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“…CHA forms particles with diameters of approximately 8 nm, and CHA@GOx forms particles with sizes of approximately 20 nm. These sizes are conducive to the presentation of simulated enzyme activity [ 50 , 51 ]. Additionally, UV–vis examination demonstrated that free GOx and CHA@GOx that had been disintegrated under acidic conditions had the same UV–vis absorption peak at 280 nm ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Yang

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Yang

et al. 2022

Materials Today Bio

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“…The nature of the interaction between a nanomedicine and the outer membrane of cells is largely dependent on the material, size and shape of the nanostructure [8]. The influence of NP material and size is well documented and understood (see recent reviews [9][10][11][12]). The influence of nanomaterial shape is less documented in comparison.…”

Section: Introductionmentioning

confidence: 99%

Exploiting Endocytosis for Non-Spherical Nanoparticle Cellular Uptake

2022

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Several challenges exist for successful nanoparticle cellular uptake—they must be able to cross many physical barriers to reach their target and overcome the cell membrane. A strategy to overcome this challenge is to exploit natural uptake mechanisms namely passive and endocytic (i.e., clathrin- and caveolin-dependent/-independent endocytosis, macropinocytosis and phagocytosis). The influence of nanoparticle material and size is well documented and understood compared to the influence of nanomaterial shape. Generally, nanoparticle shape is referred to as being either spherical or non-spherical and is known to be an important factor in many processes. Nanoparticle shape-dependent effects in areas such as immune response, cancer drug delivery, theranostics and overall implications for nanomedicines are of great interest. Studies have looked at the cellular uptake of spherical NPs, however, fewer in comparison have investigated the cellular uptake of non-spherical NPs. This review explores the exploitation of endocytic pathways for mainly inorganic non-spherical (shapes of focus include rod, triangular, star-shaped and nanospiked) nanoparticles cellular uptake. The role of mathematical modelling as predictive tools for non-spherical nanoparticle cellular uptake is also reviewed. Both quantitative structure-activity relationship (QSAR) and continuum membrane modelling have been used to gain greater insight into the cellular uptake of complex non-spherical NPs at a greater depth difficult to achieve using experimental methods.

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“…Another alternative is to produce small-size nanogels based on the clickable dextrans by an effective method such as the microfluidic technology for the promoted bioavailability of the nanogels in tumor. Recently, small-size nanoparticles as tumor-penetration delivery systems were documented, which displayed high permeability in deep tumor tissue enabling robust antitumor efficacy. − In the future work, the CDP nanogels may be further developed for combination chemotherapy against cancers. − …”

Section: Discussionmentioning

confidence: 99%

Click Nanogels from pH-Labile Dextran Prodrugs for Robust Solid Tumor Chemotherapy

Jin

Wang

Zhou

et al. 2021

ACS Appl. Polym. Mater.

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Bioresponsive prodrug nanogels are promising drug delivery systems for cancer chemotherapy due to their advantages such as a high drug-loading content (DLC) and colloidal stability. Herein, a group of polymeric nanogels from clickable dextran prodrugs (CDPs) were designed for pH-responsive drug release against solid tumors. The CDP nanogels were prepared by metal-free click-crosslinking between two clickable dextran-hydrazone-doxorubicin (DOX) prodrugs having azadibenzocyclooctyne and azide residues, respectively, also being termed as DDB/DOX and DAZ/DOX. By adjusting the amounts of these clickable residues and DOX, an equivalent molar amount of DDB/DOX and DAZ/DOX prodrugs containing five of clickable residues and three of DOX, respectively, were applied to produce the CDP5/DOX3 nanogels showing the smallest size (∼130 nm), a nearly neutral surface charge (+3.1 mV), and a high DLC (12.8%). In vitro accumulative drug release testing indicated that the CDP5/DOX3 nanogels displayed relatively slow DOX release under physiological conditions but faster DOX release in an acidic endosomal environment by virtue of the hydrolysis of acid-labile hydrazone. In vitro cytotoxicity testings supported that the CDP5/DOX3 nanogels afforded marked antitumor activity in CT-26 and LLC cancer cells as a result of the DOX delivery into the cellular nuclei. In vivo, compared to the free DOX group, the CDP5/DOX3 nanogel group possessed a higher level of DOX accumulation in CT-26 tumor xenografted in balb/c mice as well as improved DOX pharmacokinetics in the mice. Intravenous administration of the nanogels afforded significant growth repression of CT-26 tumor with a DOX dosage of 4.0 mg/kg, followed by minor systemic toxicity. Moreover, such an antitumor efficacy was much better for the nanogel group than for the free DOX group. This study highlights high potential of dextran prodrug nanogels for robust cancer chemotherapy.

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Nanoparticle Size Effects in Biomedical Applications

Cited by 117 publications

References 180 publications

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Exploiting Endocytosis for Non-Spherical Nanoparticle Cellular Uptake

Click Nanogels from pH-Labile Dextran Prodrugs for Robust Solid Tumor Chemotherapy

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