Multifunctional system for combined chemodynamic–photodynamic therapy employing the endothelin axis based on conjugated polymer nanoparticles

Jasim, Khalaf A.; Waheed, Ibrahim F.; Topps, Martin; Gesquiere, Andre J.

doi:10.1039/d1py00964h

Cited by 7 publications

(6 citation statements)

References 81 publications

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“…Pc-generated 1 O 2 has certain phototoxicity under 680 nm light irradiation. , To investigate the biocompatibility of Pc-pDMAEMA-C 4 , the cytotoxicity against RAW264.7 cells was assessed using the MTT assay. Figure shows the cell viability of Pc-pDMAEMA-C 4 at different concentrations (from 31.25 to 2000 μg/mL) with or without 680 nm light irradiation.…”

Section: Resultsmentioning

confidence: 99%

Multivalent Phthalocyanine-Based Cationic Polymers with Enhanced Photodynamic Activity for the Bacterial Capture and Bacteria-Infected Wound Healing

Mei

Shi

et al. 2022

Biomacromolecules

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The solubility and photosensitive activity of phthalocyanine are crucial to photodynamic antibacterial performance. However, highly conjugated phthalocyanine with high singlet oxygen generation efficiency tends to aggregate in aqueous environments, leading to poor solubility and photodynamic antibacterial activity. Herein, we propose a novel photodynamic antibacterial therapeutic platform by a phthalocyanine-based polymeric photosensitizer for the efficient healing of a bacteria-infected wound. A prepared phthalocyanine-based chain-transfer agent and a tertiary amino group-containing monomer are applied in the reversible addition–fragmentation chain-transfer polymerization for the preparation of the polymeric photosensitizer, which is subsequently quaternized to obtain a positively charged surface. This water-soluble phthalocyanine-based polymer can strongly concentrate on bacterial membranes via electrostatic interaction. The formed singlet oxygen by the phthalocyanine-based polymer after 680 nm light irradiation plays an essential role in killing the Gram-positive and Gram-negative bacteria. The study of antibacterial action indicates that this nanocomposite can cause irreversible damage to the bacterial membranes, which can cause cytoplasm leakage and bacterial death. Moreover, this therapeutic platform has excellent biocompatibility and the capacity to heal the wounds of bacterial infections. Experimental results indicate that the design strategy of this phthalocyanine-based polymer can extend the application of the hydrophobic photosensitizer in the biomedical field.

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Section: Resultsmentioning

confidence: 99%

Multivalent Phthalocyanine-Based Cationic Polymers with Enhanced Photodynamic Activity for the Bacterial Capture and Bacteria-Infected Wound Healing

Mei

Shi

et al. 2022

Biomacromolecules

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Section: Stimulus-responsive Multimodal Antibacterial Therapiesmentioning

confidence: 99%

“…According to the evidence demonstrated by Jasim et al, the EDN3-CP nanocomposite enabled ferroptosis-aided CDT, opening the door for combination with PDT for maximum therapeutic efficiency as a new therapeutic strategy for the treatment of tumors and antibacterial therapy. 87 A straightforward and inexpensive technique for synergistic photothermal antibacterial therapy and chemodynamic antibacterial therapy (PTAT/CDAT) was used to successfully generate infection microenvironment-activated Cu 2 O nanoparticles. 88 When exposed to a 1060 nm laser, the nanoplatform successfully prevented needless injury to healthy peripheral tissues.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Nanoparticle-mediated stimulus-responsive antibacterial therapy

et al. 2023

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“…Owing to the length limitation, we have only introduced the aforementioned examples; however, we have cited other studies for interested readers. [90][91][92][93] In addition to producing ROS for PDT, CPs could also generate heat for PTT upon NIR laser excitation if their absorption was adjusted to the NIR range. [94,95] The combination of PDT and PTT has been confirmed to improve the efficacy of treatment and decrease the risk of recurrence compared to using solely PDT or PTT.…”

Section: Several Strategies To Further Improve the Efficacy Of Cp-bas...mentioning

confidence: 99%

“…Owing to the length limitation, we have only introduced the aforementioned examples; however, we have cited other studies for interested readers. [ 90–93 ]…”

Section: Several Strategies To Further Improve the Efficacy Of Cp‐bas...mentioning

confidence: 99%

Conjugated‐Polymer‐Based Photodynamic Therapy

2022

Advanced Therapeutics

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Photodynamic therapy (PDT) is a promising method for cancer treatment owing to its high spatiotemporal precision and minimally invasive properties. The efficiency of reactive oxygen species (ROS) production by photosensitizers (PSs) directly affects PDT efficacy. Conjugated polymers (CPs) exhibit excellent light‐harvesting capabilities and effective intra‐ and intermolecular energy transfer between CPs and traditional PSs by the “molecular wire effect,” leading to a significant improvement in ROS generation efficiency when PSs are carefully paired with suitable CPs as energy donors. The recently proposed “polymerization‐enhanced photosensitization effect” further reveals that donor–acceptor type CPs can directly function as high‐performance PSs. Recently, two‐photon excitation and chemiluminescence excitation technologies are employed to enhance the penetration depth, a common challenge in phototherapy of CP‐based PDT systems. Furthermore, if precisely designed, CPs can endow the system with useful functions such as photothermal effects and drug‐delivery capacity, which can lead to a synergistic therapy with PDT. Here, recent advances are summarized in CP‐based PDT, including its underlying phenomena, mechanisms, and applications. Strategies for improving PDT performance are the focus of the discussions. In the conclusion, challenges and opportunities are discussed by considering further perspectives.

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Multifunctional system for combined chemodynamic–photodynamic therapy employing the endothelin axis based on conjugated polymer nanoparticles

Abstract: Most nanomedicines that attack tumors by Reactive Oxygen Species (ROS) based on lipid peroxidation mechanisms require external activation to work. The leading example is Photodynamic Therapy (PDT), for which an...

Cited by 7 publications

References 81 publications

Multivalent Phthalocyanine-Based Cationic Polymers with Enhanced Photodynamic Activity for the Bacterial Capture and Bacteria-Infected Wound Healing

Multivalent Phthalocyanine-Based Cationic Polymers with Enhanced Photodynamic Activity for the Bacterial Capture and Bacteria-Infected Wound Healing

Nanoparticle-mediated stimulus-responsive antibacterial therapy

Conjugated‐Polymer‐Based Photodynamic Therapy

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