Multifunctional Role of TRAIL in Atherosclerosis and Cardiovascular Disease

Mori, Katsuhito; Emoto, Masanori; Inaba, Masaaki

doi:10.5772/21991

Cited by 5 publications

(1 citation statement)

References 62 publications

(73 reference statements)

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“…TRAIL is a protein that induces caspase 8-dependent apoptosis, via death receptors DR4 and DR5 ( 75 ). It has been implicated in anticancer activity and cardiovascular disease prevention, lipid uptake and blood vessel homeostasis ( 75 , 76 , 77 , 78 , 79 ). However, TRAIL can have an opposite role in apoptosis when forming complexes with transmitters such as Fas-associated with a death domain (FADD) or caspase-8 ( 80 , 81 ).…”

Section: Molecular Pathways and Genetic Involvement In Sporadic Phptmentioning

confidence: 99%

Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: old knowledge with new tricks

Mizamtsidi

Nastos

Mastorakos

et al. 2018

Endocrine Connections

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Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management, and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Elucidation of the genetic background of each of these clinical entities would be of great interest. However, the molecular factors that control parathyroid tumorigenesis are poorly understood. There are data implicating the existence of specific genetic pathways involved in the emergence of parathyroid tumorigenesis. The main focus of the present study is to present the current optimal diagnostic and management protocols for pHPT as well as to review the literature regarding all molecular and genetic pathways that are to be involved in the pathophysiology of sporadic pHPT.

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