Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity

Xu, Fangli; Zhong, Jiaren; Qian, Xiaofei; Li, Yanyan; Lin, Xianfu; Wu, Qi

doi:10.1039/c3py00156c

Cited by 23 publications

(20 citation statements)

References 31 publications

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“…For both PGS and PTS, increasing the proportion of diethyl suberate would result in apparent growth of Den units and reduction of T units. ( Table 3 ) In addition, the dispersity increased first and then dropped, comparatively low PDI was obtained at the ratio of 1/1 or 1/2, this could possibly be referred from a former published paper, the ratios of 1/1 and 1/2 were named as stoichiometric ratio which would respectively lead to the formation of polyester completely end capped by polyol or ester groups in ideal condition.…”

Section: Resultsmentioning

confidence: 92%

Macroscopic Scaffold Control for Lipase‐Catalyzed Dendritic Polyol‐Polyesters

Rao

Yang

et al. 2019

Macro Chemistry & Physics

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Herein, structurally regular dendritic trimethylolethane (TME) polyester is robustly obtained by polymerizing with suberic acid. Through properly modeled chain growth behaviors, differences of scaffolds forming between TME and glycerol polyesters are thoroughly discussed. The scaffolds of polyol‐polyesters can be easily controlled by adjusting feed ratio and temperature. However, to achieve regular dendritic scaffolds, apart from the monomer feed ratio of 1/1 and high temperature(80 °C), selection of proper polyols is much more important. TME with three equal primary hydroxyls tends to undergo pure dendritic growth, forming into regular scaffolds while glycerol with secondary hydroxyls is inclined to have linear and grafted growth successively, which results in irregular dendritic scaffolds. However, glycerol polyesters tend to have linear growth under mild temperature (40 °C), hence, regular linear scaffolds can be obtained. Besides, a scaffold determination and control system are built up, giving general guidance of obtaining polol‐polyesters with targeted topologies.

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Section: Resultsmentioning

confidence: 92%

Macroscopic Scaffold Control for Lipase‐Catalyzed Dendritic Polyol‐Polyesters

Rao

Yang

et al. 2019

Macro Chemistry & Physics

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“…91 This synthesis is shown in Scheme 3. The reaction conditions were optimized, and the precise structure of the products, including the degree of branching, the percentages of the components, and outer surface 30 groups, were confirmed by FTIR, NMR, GPC, and so on.…”

Section: Enzyme-catalyzed Polymerizationmentioning

confidence: 98%

Synthesis of hyperbranched polymers and their applications in analytical chemistry

et al. 2015

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Hyperbranched polymers (HBPs) are increasingly attracting the attention of scientists due to their unique physical and chemical 5 properties, as well as their potential applications in different fields. Many methods for the preparation of HBPs have hitherto been reported. This review focuses primarily on several novel synthesis methods for various HBPs. We present and discuss the advantages and disadvantages as well as recent progress relating to these synthesis methods, namely the slow monomer addition method, click chemistry, and the enzyme-catalyzed polymerization method. Besides, the applications of HBPs in analytical chemistry fields such as sample pretreatment and immunosensors are also briefly summarized. 10

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“…An example of the green synthesis of hyperbranched CPLs is a lipase‐catalyzed preparation of polyfunctional poly(amine‐ester)‐type of hyperbranched polymers by polycondensation of triethanolamine with polyethers . In another interesting example, green synthesis of hyperbranched polymer is carried out the thiol‐yne photopolymerization of macromolecules carrying a thiol group at one end of the chain and an alkyne unit at the other end (Scheme ) .…”

Section: Synthesis Of Chelating Hyperbranched Polymersmentioning

confidence: 99%

Synthetic Methodologies for Chelating Polymer Ligands: Recent Advances and Future Development

Джардималиева

Uflyand

2018

ChemistrySelect

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This review summarizes recent progress in synthetic methodologies of chelating polymer ligands such as linear, branched, cross‐linked, grafted polymers, polymer films, liquid crystal polymers, dendrimers, star‐shaped and hyperbranched polymers. The features of methods for producing chelating polymer ligands are considered in detail: free‐radical (co)polymerization, living/controlled radical, metathesis, grafted, chemical oxidized, microwave‐assisted and asymmetric polymerization, electropolymerization, cyclopolymerization, polycondensation, post‐polymerization modification, click chemistry methods and “green” synthesis. The main directions of the development of synthetic chemistry of chelating polymeric ligands are analyzed. The bibliography includes works published in the last five years.

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Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity

Cited by 23 publications

References 31 publications

Macroscopic Scaffold Control for Lipase‐Catalyzed Dendritic Polyol‐Polyesters

Macroscopic Scaffold Control for Lipase‐Catalyzed Dendritic Polyol‐Polyesters

Synthesis of hyperbranched polymers and their applications in analytical chemistry

Synthetic Methodologies for Chelating Polymer Ligands: Recent Advances and Future Development

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