Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation

Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia

“…REDV peptide, cell-penetrating peptide and anionic polymers have been used to modify gene carriers to improve biocompatibility, cellular uptake and endosomal escape. 51,52 In vitro and in vivo results showed that they achieved perfect transfection effectiveness in the proliferation and migration of HUVECs, and accelerated neovascularization and angiogenesis. 53…”

Editorial: Multifunctional Polymeric Materials for Drug and Gene Delivery

“…In recent years, various multifunctional polymers have been vastly explored as drug/gene carriers intended to deliver therapeutic reagents (Guo et al, 2019;Duo et al, 2020;Zhang et al, 2020). Their unique physical and biochemical properties render them new functions and possibilities such as targeting, bio-responsiveness, biointeractivity and adaptivity.…”

Enzyme-responsive strategy as a prospective cue to construct intelligent biomaterials for disease diagnosis and therapy

“…Stimulus-responsive materials are defined as those materials that can be triggered to undergo structure, property and function changes in response to physical or/and chemical stimuli, including pH, temperature, light, enzymes, and redox and hypoxia environments. [1][2][3][4][5][6][7][8] These materials exhibit intelligent characteristics and are widely applied in biomaterials and tissue engineering, such as drug/gene delivery [9][10][11][12][13][14][15] and cell culture. 1 The trigger plays an important role in stimulus-responsive materials, 16 including pH, temperature, light, enzymes, redox conditions, etc., in which the enzymes are a type of natural biomacromolecule in the organism and significantly participate in various life activities.…”